<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP33367

Description Mediator of RNA polymerase II transcription subunit 12
SequenceMPPSKYLLTPPDDLHPLTDSEQPIYPDFDPWVHTREEDKVLNEFVAKGYYTASKVNFETISARSALQGSLPKISSLLGEELSKIIQIREEEINKIGTFDSDESARFTKWAGQDYHLPNRVTLTDQKRNLWLQELSSSSSSLQSLTKSVPHGFRKRYILEQCYIQFVPIYRFIWLIKSCYAIEWKGMVSKAKGEISSDELLRTLYKDWTDSMVVVLEKLVFEVTKYYNDPSQLKLWKLRIAHYLKMLGSCYERELLNKNAMHQWIVDFVSKVESFEFYPMALHILSIFWNGILGTTEEDAETESSFLVIKLSEILLRKYHIVSESKCMINDSKYIINDIQRNSRLKESVLQRLKQFIAHIFHTQSLEAFIMPKQNWNIYKNYLYHILLQNVPERDAQKLKKKLKLISYRNESLRLGSLDMEPSRESSPYNSELALEDVFSGSILNLKNVNPELLSMLDSGLSGSEWGVFVDQKITRMEQVIEIILWSINPSKKHRYDSCHLVAKILVLKMNSQESFQEYGIEDVIWSLIFHFSKLSKLELRKTVWLPKLHQLLNVFIGYGIIKVPTYIRRLISSGVLYLPESENKNFHCKLLINLKISPVMKSQYNMVLKNVSEYAPHFYQQYNFDELVSVFESLKVKLLNGDFEGLEKYPGSIRIMCSEWYLSQICFNQGEMQKIDKKKIIDTFNLFCNTLGELHHFFGWAEYIVYHQLIDDLEILEVFTDILLYLDKAFLLLINDPILFMKTLLHSYTRDLKNKDKAAFELLSYKNFWKFFVKNCSNIIEMDSALQSLIAEVFEIERTKKEKFMKTPSESLAVFLELTGNKHTKLEDQNFPSVIQQNIKKLLHNPEDESTSRKILLLCKASNSTEYNKFLSIFVKRGDFTADELVKLISLRLLSFEVIQKTSHDDILCELVSENNFTYGLNFENEKNAFIRRNFKYVCLQLFPNPQYRQTLVKLLVEYGPNSSFTEKSASVVSHILMEENNMSIIREILLYGMNIQNDPTDNVMDLYQYLNFTNTWLFQILTEFNVNHSESESLSSFFSNIVKTIGCNSLLPKIFSNISDSSSVFTMLTVIEGQFLSKVLDTDKSSMTFLQIMMDTEIVLSRQHINVMTLEMDSSVLELFKERISQFAKMSSDELKQYDENLNELLKMVITHEKFILRHCFESVKLRDTSMIENFYILFQKTSKDLKLKLLLYDLLTSLKSYILDGMKEQSSANIKMPAVLTNLPKFAISSFLGSENSDEDFVERDQPELIHLGLYDAENKKASNKKYFVFNKKTSQFDSAFRIEPFQYLVNYQEPLEGCLNNTSLSLGLFDARLEKTNPS
Length1322
PositionKinase
OrganismKluyveromyces marxianus (strain DMKU3-1042 / BCC 29191 / NBRC 104275) (Yeast) (Candida kefyr)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes> Saccharomycetales> Saccharomycetaceae> Kluyveromyces.
Aromaticity0.11
Grand average of hydropathy-0.219
Instability index48.17
Isoelectric point6.13
Molecular weight154166.94
Publications
PubMed=25834639

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IEA:EnsemblFungi

GO - Biological Function
transcription coactivator activity	GO:0003713	IEA:EnsemblFungi

GO - Biological Process
negative regulation of transcription by RNA polymerase II	GO:0000122	IEA:EnsemblFungi
positive regulation of transcription by galactose	GO:0000411	IEA:EnsemblFungi
positive regulation of transcription by RNA polymerase II	GO:0045944	IEA:EnsemblFungi









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP33367
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     259.24|      75|     194|     382|     471|       1
---------------------------------------------------------------------------
  383-  463 (112.38/77.55)	YHILLQnvpeRDAQKLkkKLKLISYR.NESLRLGSLDMEPSRESSPYNSEL..ALEDV..FS.GSILNLKNVNPELL.....SMLDSGLSGS
  887-  931 (54.18/24.30)	....................KLI......SLRLLSFEVIQKTSHDDILCEL..VSENN..FT.YG.LNFENEKNAFI...............
 1176- 1259 (92.68/48.94)	FYILFQ....KTSKDL..KLKLLLYDlLTSLKSYILD..GMKEQSSANIKMpaVLTNLpkFAiSSFLGSENSDEDFVerdqpELIHLGLYDA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.12|      15|      15|    1113|    1127|       3
---------------------------------------------------------------------------
 1113- 1127 (23.99/16.29)	MDSSVLELFKERISQ
 1131- 1145 (25.12/17.47)	MSSDELKQYDENLNE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      89.72|      30|     194|     762|     819|       4
---------------------------------------------------------------------------
  346-  378 (49.30/16.37)	ESVLQRLkqfIAHIFHTQSL..EAFI.MPKQNWNIY
  783-  815 (40.42/ 8.37)	DSALQSL...IAEVFEIERTkkEKFMkTPSESLAVF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      40.74|      11|      38|     477|     487|       5
---------------------------------------------------------------------------
  477-  487 (19.78/11.05)	EQVIEIILWSI
  517-  527 (20.96/12.15)	EYGIEDVIWSL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     121.25|      51|     432|     577|     643|       6
---------------------------------------------------------------------------
  577-  643 (62.69/79.21)	YLpeseNKNFhcKLLINLKISpVMKS...QYNMVLKN.....................................................................................................................................................................................................................................................................................................vseyaPHFYQqyNFDELVSVFESLKVklLNGDF
  725-  754 (31.09/11.30)	YL....DKAF..LLLINDPIL.FMKTllhSYTRDLKN......................................................................................................................................................................................................................................................................................................................................
 1053- 1076 (27.47/ 7.96)	.....................................kdkaafellsyknfwkffvkncsniiemdsalqsliaevfeiertkkekfmktpseslavfleltgnkhtkledqnfpsviqqnikkllhnpedestsrkilllckasnsteynkflsifvkrgdftadelvklislrllsfeviqktshddilcelvsennftyglnfeneknafirrnfkyvclqlfpnpqyrqtlvkllveygpnssfteksasvvshilmeennmsiireillygmniqndptdnvmdlyqylnftntwlfqiltefnvnhseseslssffsnivktigcnsllPKIFS..NISDSSSVFTMLTV..IEGQF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.85|      14|      15|     148|     162|       7
---------------------------------------------------------------------------
  148-  162 (23.31/19.93)	VPhGFRKRYILEQCY
  166-  179 (28.55/18.42)	VP.IYRFIWLIKSCY
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP33367 with Med12 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




NANANA









Molecular Recognition Features






MoRF SequenceStartStop




NANANA