<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP33367

Description Mediator of RNA polymerase II transcription subunit 12
SequenceMPPSKYLLTPPDDLHPLTDSEQPIYPDFDPWVHTREEDKVLNEFVAKGYYTASKVNFETISARSALQGSLPKISSLLGEELSKIIQIREEEINKIGTFDSDESARFTKWAGQDYHLPNRVTLTDQKRNLWLQELSSSSSSLQSLTKSVPHGFRKRYILEQCYIQFVPIYRFIWLIKSCYAIEWKGMVSKAKGEISSDELLRTLYKDWTDSMVVVLEKLVFEVTKYYNDPSQLKLWKLRIAHYLKMLGSCYERELLNKNAMHQWIVDFVSKVESFEFYPMALHILSIFWNGILGTTEEDAETESSFLVIKLSEILLRKYHIVSESKCMINDSKYIINDIQRNSRLKESVLQRLKQFIAHIFHTQSLEAFIMPKQNWNIYKNYLYHILLQNVPERDAQKLKKKLKLISYRNESLRLGSLDMEPSRESSPYNSELALEDVFSGSILNLKNVNPELLSMLDSGLSGSEWGVFVDQKITRMEQVIEIILWSINPSKKHRYDSCHLVAKILVLKMNSQESFQEYGIEDVIWSLIFHFSKLSKLELRKTVWLPKLHQLLNVFIGYGIIKVPTYIRRLISSGVLYLPESENKNFHCKLLINLKISPVMKSQYNMVLKNVSEYAPHFYQQYNFDELVSVFESLKVKLLNGDFEGLEKYPGSIRIMCSEWYLSQICFNQGEMQKIDKKKIIDTFNLFCNTLGELHHFFGWAEYIVYHQLIDDLEILEVFTDILLYLDKAFLLLINDPILFMKTLLHSYTRDLKNKDKAAFELLSYKNFWKFFVKNCSNIIEMDSALQSLIAEVFEIERTKKEKFMKTPSESLAVFLELTGNKHTKLEDQNFPSVIQQNIKKLLHNPEDESTSRKILLLCKASNSTEYNKFLSIFVKRGDFTADELVKLISLRLLSFEVIQKTSHDDILCELVSENNFTYGLNFENEKNAFIRRNFKYVCLQLFPNPQYRQTLVKLLVEYGPNSSFTEKSASVVSHILMEENNMSIIREILLYGMNIQNDPTDNVMDLYQYLNFTNTWLFQILTEFNVNHSESESLSSFFSNIVKTIGCNSLLPKIFSNISDSSSVFTMLTVIEGQFLSKVLDTDKSSMTFLQIMMDTEIVLSRQHINVMTLEMDSSVLELFKERISQFAKMSSDELKQYDENLNELLKMVITHEKFILRHCFESVKLRDTSMIENFYILFQKTSKDLKLKLLLYDLLTSLKSYILDGMKEQSSANIKMPAVLTNLPKFAISSFLGSENSDEDFVERDQPELIHLGLYDAENKKASNKKYFVFNKKTSQFDSAFRIEPFQYLVNYQEPLEGCLNNTSLSLGLFDARLEKTNPS
Length1322
PositionKinase
OrganismKluyveromyces marxianus (strain DMKU3-1042 / BCC 29191 / NBRC 104275) (Yeast) (Candida kefyr)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes> Saccharomycetales> Saccharomycetaceae> Kluyveromyces.
Aromaticity0.11
Grand average of hydropathy-0.219
Instability index48.17
Isoelectric point6.13
Molecular weight154166.94
Publications
PubMed=25834639

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IEA:EnsemblFungi

GO - Biological Function
transcription coactivator activity	GO:0003713	IEA:EnsemblFungi

GO - Biological Process
negative regulation of transcription by RNA polymerase II	GO:0000122	IEA:EnsemblFungi
positive regulation of transcription by galactose	GO:0000411	IEA:EnsemblFungi
positive regulation of transcription by RNA polymerase II	GO:0045944	IEA:EnsemblFungi









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP33367
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     259.24|      75|     194|     382|     471|       1
---------------------------------------------------------------------------
  383-  463 (112.38/77.55)	YHILLQnvpeRDAQKLkkKLKLISYR.NESLRLGSLDMEPSRESSPYNSEL..ALEDV..FS.GSILNLKNVNPELL.....SMLDSGLSGS
  887-  931 (54.18/24.30)	....................KLI......SLRLLSFEVIQKTSHDDILCEL..VSENN..FT.YG.LNFENEKNAFI...............
 1176- 1259 (92.68/48.94)	FYILFQ....KTSKDL..KLKLLLYDlLTSLKSYILD..GMKEQSSANIKMpaVLTNLpkFAiSSFLGSENSDEDFVerdqpELIHLGLYDA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.12|      15|      15|    1113|    1127|       3
---------------------------------------------------------------------------
 1113- 1127 (23.99/16.29)	MDSSVLELFKERISQ
 1131- 1145 (25.12/17.47)	MSSDELKQYDENLNE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      89.72|      30|     194|     762|     819|       4
---------------------------------------------------------------------------
  346-  378 (49.30/16.37)	ESVLQRLkqfIAHIFHTQSL..EAFI.MPKQNWNIY
  783-  815 (40.42/ 8.37)	DSALQSL...IAEVFEIERTkkEKFMkTPSESLAVF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      40.74|      11|      38|     477|     487|       5
---------------------------------------------------------------------------
  477-  487 (19.78/11.05)	EQVIEIILWSI
  517-  527 (20.96/12.15)	EYGIEDVIWSL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     121.25|      51|     432|     577|     643|       6
---------------------------------------------------------------------------
  577-  643 (62.69/79.21)	YLpeseNKNFhcKLLINLKISpVMKS...QYNMVLKN.....................................................................................................................................................................................................................................................................................................vseyaPHFYQqyNFDELVSVFESLKVklLNGDF
  725-  754 (31.09/11.30)	YL....DKAF..LLLINDPIL.FMKTllhSYTRDLKN......................................................................................................................................................................................................................................................................................................................................
 1053- 1076 (27.47/ 7.96)	.....................................kdkaafellsyknfwkffvkncsniiemdsalqsliaevfeiertkkekfmktpseslavfleltgnkhtkledqnfpsviqqnikkllhnpedestsrkilllckasnsteynkflsifvkrgdftadelvklislrllsfeviqktshddilcelvsennftyglnfeneknafirrnfkyvclqlfpnpqyrqtlvkllveygpnssfteksasvvshilmeennmsiireillygmniqndptdnvmdlyqylnftntwlfqiltefnvnhseseslssffsnivktigcnsllPKIFS..NISDSSSVFTMLTV..IEGQF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.85|      14|      15|     148|     162|       7
---------------------------------------------------------------------------
  148-  162 (23.31/19.93)	VPhGFRKRYILEQCY
  166-  179 (28.55/18.42)	VP.IYRFIWLIKSCY
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP33367 with Med12 domain of Kingdom Fungi
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