<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP33366

Description Mediator of RNA polymerase II transcription subunit 15
SequenceMDDWRSSISAQERTQFVTELAQILADMSRINGGEKANFNLEKLKKSAEQFESSLYASCNSKELYLDAMRKRIAAMDSAKRKSIEAQRQKLAQAAQAAQRQQQQQQQQQLQKQQGNNGIPANINAQMFLNQQAQARQQAQRQIRSSLTGQQMQQLQQQQQQQQQQQQQQQQSPNMMRPQLTLQQQQQLANELKVTEIPRELLQKIPNLPAGITTWPQITDWAQKNRPSQNDLIITKKVYQLHQQLLIKSKLQQSNVNRMNTSAQQVMGMQQMPTNQRMAMNQQMQPQPQPQSQPQPQPQPQPQPQPQLQQPQPHHQEAPAVLNRLNQVFTQAEQKMLYEAGKKMIENLQRSGKLPPNLDNQQQLLYIKKYMNQMVLKKMQQLGIPIPMPGSAQRQTHQPQPQPQSQPQPQQRQPQQQPQLQQPQPQLQQPSIQQQPNQQVPQAQQAQARRQAMAMKSNPVGGVMNLQSQQAQQAQQAQQSPQMTQQPMMQQAQQQAQQQQQAQQSQPPKISIPRPTEQDMLALKKLNAEVTKNPVKLNDITNRLTNEQKQQIRSKLHANQQLFSSVESFIPTLYMLTRNEEHIRQLLQIRMLTREIMEKAVRGIFLVEPNVVDKVIFRYQKYYEYTKEQLLRRQQQLMAMRQMQNNNPNLTANELMKQQQMLQARKQSMGVQQQQQQQQQQQQQQQALKQNQLNIQQQQQQKMAGTGNNPNVGIVLDSSMNAASRSGTNMEFLNSPEFNAISPAVPSPNKDKKTPASRAVKGKKNLQPGIPTSNPQSNSNPSVVNSRTTTPSMVPGSSPMVNNKSLAPGQLSTPSPKTVVTSPIRQDNPYKNDELVLKKMAIRKAELMSRYKHRKEVFASSAIDLFLSTFADCLDIKDDAVDLVQKSPQPIIDQINGTGKKKLSKAAQKAREQDPVEISVKNNKLLMPSKSEKALRSFKIPISDITACFKPFVDPKHLILTSTPNPDDRKRKLDDLEISPTDSSSELMSESKKVKFDSPDDMFLNDPSSVHDIKPLVSSDLGVNSNNLKNAVPSMTSQNPTTNGSTDSSTNIWDWNYWENL
Length1060
PositionTail
OrganismKluyveromyces marxianus (strain DMKU3-1042 / BCC 29191 / NBRC 104275) (Yeast) (Candida kefyr)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes> Saccharomycetales> Saccharomycetaceae> Kluyveromyces.
Aromaticity0.04
Grand average of hydropathy-0.988
Instability index71.20
Isoelectric point9.92
Molecular weight120721.63
Publications
PubMed=25834639

Function

Annotated function 
GO - Cellular Component
core mediator complex	GO:0070847	IEA:EnsemblFungi
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
RNA polymerase II activating transcription factor binding	GO:0001102	IEA:EnsemblFungi
TFIIE-class transcription factor complex binding	GO:0001095	IEA:EnsemblFungi
TFIIH-class transcription factor complex binding	GO:0001097	IEA:EnsemblFungi
transcription coactivator activity	GO:0003713	IEA:EnsemblFungi

GO - Biological Process
negative regulation of transcription by RNA polymerase II	GO:0000122	IEA:EnsemblFungi
positive regulation of invasive growth in response to glucose limitation	GO:2000219	IEA:EnsemblFungi
positive regulation of transcription by RNA polymerase II	GO:0045944	IEA:EnsemblFungi
regulation of establishment of protein localization to chromosome	GO:0070202	IEA:EnsemblFungi
RNA polymerase II preinitiation complex assembly	GO:0051123	IEA:EnsemblFungi









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP33366
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             7|     828.14|     109|     110|     205|     313|       1
---------------------------------------------------------------------------
   17-  115 (99.96/18.14)	......VTELA.QI..............lADMSRI.....NGG..........EKANFNL.EKL...KKSAEQF....ES................SLY........AScN.....S.KELYL.......................................DA.....MR.KriaaMDSA.KRK..............SIEAQ..RQKLA.QAAQAAQRQQQQQQQQQLQK.......QQGN
  116-  200 (110.20/20.77)	NGIPANINAQM.FL...............NQQAQA.....RQQ..........AQ......RQ..............IRS................SL.......................T.........................................GQQ...MQ.Q....LQQQ.QQ.................QQQQQQQQQQ.QSPNMMRPQLTLQQQQQLANelkvteiPREL
  205-  313 (206.00/45.38)	PNLPAGITTWP.QI...............TDWAQK.....NRP..........SQNDLIITKKV...YQLHQQLL..IKS................KLQ........QS.N.....V.NRMNT.......................................SAQQVMGMQ.Q....MPTN.QRM..............AMNQQMQPQPQP.QSQPQPQPQPQPQPQPQLQQ.......PQPH
  315-  425 (133.52/26.76)	QEAPAVLNRLN.QV..............fTQAEQKmlyeaGKK..........MIENLQRSGKLppnLDNQQQLL.yIKK................YMN........QM.V.....L.KKM...........................................QQ.LGIPiP....MPGSaQR..................QTHQPQPQP.QSQPQPQ.QRQPQQQPQLQQ.......PQPQ
  428-  515 (99.82/18.11)	..............................QPSIQ.....QQP..........NQ.............QVPQAQQ..AQA................RRQ....amamKS.N....pVgGVMNL.......................................QSQQAQQAQ.Q....AQQS.PQM..............TQQPMMQ.QAQQ.QAQQQQQAQ.QSQP.PKISI.......PRPT
  523-  698 (103.02/18.93)	KKLNAEVTKNPvKL...............NDITNR.....LTN..........EQKQQ.IRSKL...HA.NQQLFssVESfiptlymltrneehirQLL........QI..........RMLTreimekavrgiflvepnvvdkvifryqkyyeytkeqllrRQQQLMAMR.Q....MQNN.NPNltanelmkqqqmlqARKQSMGVQQQQ.QQQQQQQQQQQALKQNQLNI.......QQQQ
  699-  828 (75.63/11.89)	QQKMAGTGNNP.NVgivldssmnaasrsgTNMEFL.....NSPefnaispavpSPNK...DKKT....PASRAVK..GKK................NLQpgiptsnpQS.NsnpsvV.NSRTT.......................................TPSMVPGSS.P....MVNN.KSL..............APGQLSTPSPKTvVTSPIRQDNP.....................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.92|      13|      22|     829|     841|       4
---------------------------------------------------------------------------
  829-  841 (21.70/19.63)	YKNDELVLKKMAI
  850-  862 (22.21/20.30)	YKHRKEVFASSAI
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP33366 with Med15 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) AMDSAKRKSIEAQRQKLAQAAQAAQRQQQQQQQQQLQKQQGNNGIPANINAQMFLNQQAQARQQAQRQIRSSLTGQQMQQLQQQQQQQQQQQQQQQQSPNMMRPQLTLQQQ
2) ILTSTPNPDDRKRKLDDLEISPTDSSSELMSESK
3) KKMQQLGIPIPMPGSAQRQTHQPQPQPQSQPQPQQRQPQQQPQLQQPQPQLQQPSIQQQPNQQVPQAQQAQARRQAMAMKSNPVGGVMNLQSQQAQQAQQAQQSPQMTQQPMMQQAQQQAQQQQQAQQSQPPKISIPRPTEQDMLALKKLNA
4) MLQARKQSMGVQQQQQQQQQQQQQQQALKQNQLNIQQQQQQKMAGTGNNPNVGIVLDSSMNAASRSGTNMEFLNSPEFNAISPAVPSPNKDKKTPASRAVKGKKNLQPGIPTSNPQSNSNPSVVNSRTTTPSMVPGSSPMVNNKSLAPGQLSTPSPKTVVTSPIRQDNPYKNDELV
5) QAEQKMLYEAGKKMIENLQRSGKLPPNLDNQQQLLYI
6) SKLQQSNVNRMNTSAQQVMGMQQMPTNQRMAMNQQMQPQPQPQSQPQPQPQPQPQPQPQLQQPQPHHQEAPAVLNRLNQVF
74
958
376
660
330
248
184
991
527
835
366
328










Molecular Recognition Features






MoRF SequenceStartStop




1) IWDWNYWENL
1051
1060