<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP33364

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMWTNVFKIGSLHQISWFQFLPHEPDLNPLPDKSVKVDQKDVANLLVLSSHLQLQKEGFLGTWTNSFVGPWDPSQGLHNPDEKIKLWLFLPGRHSSVVESAQPAVSRLRVVASGLWLAPGDSEEVAAALSQALRNRIERALLGLYYMRFGDVFSKFHQFQSEELFRRGQPAVEFAFAATEEAIFIHVIVSSKHIRMLTTSDLEKVLKHSTESACRLPVIVSPHGIRGSLTGCSPSDLVKQSYFSSTKFRVSNGIIGLPYNVSQGVGCQLRGQNCYVEVSLGFPRSGTDNSLQPNRTSARNLPTLHVAESPITGRSDHKGSADHLSDYEKTFLYPAEAVLVPVLQTSLARSSLRRFWLQNWMGPSLPGSSSLIHCAGNVDCCEDPWTEINGARTQNSYDSSSNSNSSSISSLSASSSDSDYKTTGPSELEADADSLTCRQSMVSSADQLESDGPKLGSKRSRTGVTESLSTAANIPVQDTYMSDFGSVEVNNSAITGVGNEPIGSYWDWDDDDRGMEMDIQALLSEFGDFGDFFENDVLPFGEPPGTAESQALMFSSPDYGDVNSSPGGVIDVPDQILLPVGFPSFESFNPPPSTSVEECLNKSQDNLNNSMSLGPTNQTQMLYTREFDHIMKAEAMMTFAPEFGAVETPTYELSTTLFRSPYFPKCRKAESSNSSSNNYLYGAAPPSSPCTEGSEGKNGMSFNTKTGSGKHDSGTSLHSKHYYTFVESRKEKNDKNPVVCNDNSIAKSDGILSLSNIGSNAIVKSSLRKTAEGTHEPEHALLSAKTLLATDITCVMLQASVCRLRHVLLSSGNLMPVGFSRSTGVSFFNQLPSEPSTTTDNISGKYDVKKKENIPIRIAGDIDGGMLDGHLNAPVGVWRTLGASKVVKPSNSPNMEVGPSFSHNSFNEEGILSYGQRKPLQELLDGIALLVQQAISFVDLALDADCGDGPYGLLAMQEQWRRGFCCGPSMVHAGCGGTLASSHSLDIAGLDLVDPLSADVHASTVISLLQSDIKTALKSAFSNLEGPLSITDWCKGCNPLVDTGSIVEGVSVESTNNECRDSSEPMSPSQSSVGGSSSIKVSNIMDGAKGDETSQRRSGHDLCNTESEQQTCARLKPTLIALPFPSILVGYQDDWLKTSANSLQHWEKAPLEPYALQKPITYHVVCPDIDPLTSAAADFFQQLGTVYETCKLGTHSPQGLGNQMEIESSKLSSCGFVLLDCPQSMKIESSNASLVGSVSDYFLSLSNGWDMTSYLKSLSKALRGLKIGSCFSTNPSEGSNSSCLVIYVVCPFPDPTAILQTVIESSVAIGSVVQQLDRERKSSLHSQVVKALSGLATVDEASPSNILVLSGFSIPKLVLQIVTVDAIFRVTSPSVSELVILKETAFTVYCKARRISRGISSDFAQSAFSGRSHSVLTQLPSPISGMWKDCVGPRMAGHSLPREGDIDASLRPGTWDNSWQPTRTGGLNCDPSRTGDIFLHDEIRYMFEPLFILAEPGSLDNGISVIGSPTSESSKALVDDSSGNYVQSTSTTGSVESASSADGSGSDLKTPPSLHCCYGWTEDWRWLVCIWTDSRGELLDCNIFPFGGISSRQDTKGLQCLFVQILQQGCLIIQSCDPGLAKPRDFVIARIGGFYELEYLEWQKAIYSVGVSEMKRWPLQLRKSMSDGLSATSNGSSLQQPDMSLIPERTLPSSPSPLYSPHTKSTGFMKGNLGQPAARKQLMGGHSMVDNSRCLLHWAQSISFVAVSMDHTLQLVLPADSSTPSYIEGFTPVKSLGSTSSAYILIPSPSMRFLPPTVLQLPTCLTAESPPLAHLLHSKGSALPLSTGFVVSKAVPSMRKDYRSNLKEEWPSILSVSLIDYYGGTNIPQEKVVRGINKQVGRSLSWEAKDFEIETHLVLESIAAELHALSWMTVSPTYLERRTALPFHCDMVLRLRRLLHFADKELSKHSDKS
Length1952
PositionKinase
OrganismPhaseolus vulgaris (Kidney bean) (French bean)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> rosids> fabids> Fabales> Fabaceae> Papilionoideae> 50 kb inversion clade> NPAAA clade> indigoferoid/millettioid clade> Phaseoleae> Phaseolus.
Aromaticity0.07
Grand average of hydropathy-0.227
Instability index52.77
Isoelectric point5.46
Molecular weight211814.22
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP33364
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     106.40|      32|      54|     500|     531|       1
---------------------------------------------------------------------------
  500-  531 (63.31/39.37)	PIGS............YWDWDDDDRG.MEMDIQALLS.EFGDFGDF
  542-  587 (43.09/24.11)	PPGTaesqalmfsspdYGDVNSSPGGvIDVPDQILLPvGFPSFESF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.91|      16|      54|      73|      88|       2
---------------------------------------------------------------------------
   73-   88 (31.11/18.36)	SQGLHNPDEKIKLWLF
  129-  144 (26.79/14.84)	SQALRNRIERALLGLY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      33.72|       9|      57|       2|      16|       3
---------------------------------------------------------------------------
    2-   16 (11.19/19.09)	WTNVFkIGslhqiSW
   62-   70 (22.53/11.10)	WTNSF.VG.....PW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.19|      11|      56|     815|     825|       4
---------------------------------------------------------------------------
  815-  825 (21.01/11.33)	PVGFSRSTGVS
  873-  883 (22.18/12.40)	PVGVWRTLGAS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.07|      15|      22|     660|     681|       7
---------------------------------------------------------------------------
  660-  674 (29.67/ 7.85)	PYFPKCRKAESSNSS
  685-  699 (25.40/15.31)	PSSPCTEGSEGKNGM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     121.46|      36|     583|     829|     868|       8
---------------------------------------------------------------------------
  829-  868 (51.66/38.23)	QLPSEPSTTTDNISGKYdvKKKENIPiRiAGDIDGGMLDG
 1417- 1452 (69.80/36.82)	QLPSPISGMWKDCVGPR..MAGHSLP.R.EGDIDASLRPG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      83.36|      22|     583|     352|     384|      10
---------------------------------------------------------------------------
  362-  384 (39.88/39.45)	PSLPGSSSLIHCAGNVDCCEDpW
 1538- 1559 (43.48/15.83)	SSADGSGSDLKTPPSLHCCYG.W
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     104.30|      29|     583|     194|     228|      12
---------------------------------------------------------------------------
  178-  192 (11.34/ 9.20)	..........TEEAIFIHVIVSSKH.....
  199-  228 (46.95/29.33)	SDLEKVLKHSTESACRLPVIVSPHGiRGSL
  324-  351 (46.00/23.79)	SDYEKTFLYPAE.AVLVPVLQTSLA.RSSL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     197.98|      59|      67|    1198|    1264|      15
---------------------------------------------------------------------------
 1165- 1191 (28.23/ 8.33)	.......................CP........DI.......DPLTSAAADFFQQLGTVYE.TCKL...........
 1205- 1264 (100.19/66.80)	IES........SKLSSCGFVLLDCP........QSMkIESSNASLVGSVSDYFLSLSNGWDMTSYLKS.LSKALRGL
 1266- 1334 (69.57/31.47)	IGScfstnpseGSNSSCLVIYVVCPfpdptailQTV.IESSVA..IGSVVQQL.....DRERKSSLHSqVVKALSGL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     113.62|      33|     826|     232|     265|      17
---------------------------------------------------------------------------
  232-  265 (54.03/40.78)	SPSDLVKQSYFSSTKFRVSNGIIGLPYNvSQGVG
 1097- 1129 (59.59/40.49)	SGHDLCNTESEQQTCARLKPTLIALPFP.SILVG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     118.87|      37|     826|     982|    1020|      18
---------------------------------------------------------------------------
  982- 1020 (54.51/41.28)	HSLDIAGLDLvdPLSADVHASTVISLLQSDIKTALKSAF
 1813- 1849 (64.36/42.49)	HLLHSKGSAL..PLSTGFVVSKAVPSMRKDYRSNLKEEW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      84.08|      26|      59|     399|     431|      21
---------------------------------------------------------------------------
  397-  423 (38.63/30.78)	DSSSNSNSSSISSlSASSSDSDYKTTG
  430-  455 (45.46/19.29)	DADSLTCRQSMVS.SADQLESDGPKLG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      36.57|      11|    1045|     475|     487|      25
---------------------------------------------------------------------------
  475-  487 (16.39/20.23)	VQDTymSDFGSVE
 1525- 1535 (20.18/13.51)	VQST..STTGSVE
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP33364 with Med13 domain of Kingdom Viridiplantae
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