<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP33314

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMAAELGQQTVELSTLVTRAAHDSYASLKELVDKCRSSELSDTDKKISILKFLSKTQQRMIRLNVLSKWCQQVPLIQHCQQLASTVSNHDMCFTQAADSLFFMHEGLQQARAPVYDVPSAIDILLTGSYQRLPKCVEDVGTQYALTEDQQKPALKKLDTLVRSKLLQVSIPKEFSDIKVSDGTAMLRVVGEFKVLITLGYRGHLSLWRILHLELLVGEKNKTVKLEEMRRHVLGDDLERRMAAAENPFSVLYSVLHELCVALVMDTVIRQVQVLRQGRWKDAIRFELISEGHGASSSSAQNPDGESESSALRTPGLKIVYWLDFDKSANVSESGTCPFIKIEPGSDLQIKCLHSSFVIDPLTGKEAEFVLDQSCIDVERLLLRAICCNKYTRLLEIKRELVKNVQVCRTVDDVVLQSRMGEPDIEYKQKDDKCCSKDSEGHEVLCVRAYGSSFFTLGINIRNGRFLLQSSQNIVVSSALIECEEALNQGSMTAAEVFISLRSKSILHLFASIGRVLGLEVYEHGFNIVKIPKDASNGSAMLVMGFPDCGSSYFLLMQLDKDFKPLFKLLETQPDPSGTDNLSGGDLNQVLRIKKIDIGQMQVHEDEMNLSLVDWGKLRSVLPNAIGPNQTSAHEFFSDIRLENSVQIARGHPSGFSSLVDEVFGLEKGSSVAPLSVQNVPSSGNTSLPSQYGSVPMNIHSLKAGSPSPKWEGGMQMAQVNNVTKASGATSLYSGSLFSSGSVKGPVQSSSVGSIPTGHVRNTAGKKLSASKSEQDLASPKSPHSVDISSSIAIDEEQLRVLNDTSNEALSGSRSSRLLSPPRPTGSRMSIPNSRPNGPQADSFKVIGSASCATTPVSQTLESTVSYIAGEDVTSKNDKKSRKRTASDMLTLIPSLQGVENNPGICKRRKISDSSGCQLSLPQGAMSAEMIPKTEGYSYGSLIAEVNKGTVPSSIYIASLLHVVRHCSLCIKHARLTSQMDALDISYVEEVGLRSGSSNIWFRLPLARGDSWQHICLRLGRPGCMYWDVKINDQHFRDLWELQKGSNNTPWGSGVRIANTSDIDSHIHYDPDGVVLSYQSVEVDSIKKLVADIQRLANARTFALGMRKLLGVRAEEKSDELVTSTDSKIPSTKVASDTADKLSEQMRRAFRIEAVGLMSLWFSFGSSVLARFVVEWESGKEGCTMHVSPDQLWPHTKFLEDFINGAEVSSLLDCIRLTAGPLHALAAATRPARAGPVPGVAAALSSIPKQSGGYISSQGLLLGNSTTNVGQPASGPGANTVMPTASGPTNQTLSMLAAAGRGGPGIVPSSLLPIDVSVVLRGPYWIRIIYRKQFSVDMRCFAGDQVWLQPATPPKEGRLSGGSLPCPQFRPFIMEHVAQELNGLDPSFTGQQAGGLTNSNNPNPGSGSQMMAANGNRINLPISAAMSRTGNQVASLNRVGNALAGSSNLALMTSPVSLRRPPGAVVPAHVRGELNTAIIGLGDDGGYGGGWVPLVALKKVLRGILKYLGVLWLFAQLPDLLKEILGSILKENEGALLNLDPEQPALRFFVGGYVFAITVHRVQLLLQVLSVKRFHQQQQQQQQNSNPAPEELSPSEISEICDYFSRRVASEPYDASRVASFITMLTLPVSVLREFLKLIAWKKGLSQTQVGDVVSAQKPRIELCLENHSGLNVDENSESSSAFRSNIHYDRVHNSVDFALTVVLDSSHVPHVNAAGGAAWLPYCVSVRLRYSFGESSNVSFVAMNGSHGGRACWLRVDDWEKCKQRVARAVEVNGSSAADVSQGRLKLVADSVQRNLHMCIQGLRDGNGVTTSSGAT
Length1815
PositionTail
OrganismPhaseolus vulgaris (Kidney bean) (French bean)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> rosids> fabids> Fabales> Fabaceae> Papilionoideae> 50 kb inversion clade> NPAAA clade> indigoferoid/millettioid clade> Phaseoleae> Phaseolus.
Aromaticity0.06
Grand average of hydropathy-0.163
Instability index42.11
Isoelectric point7.92
Molecular weight197292.63
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU365082

GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP33314
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     180.92|      49|      49|     994|    1042|       1
---------------------------------------------------------------------------
  951-  983 (34.83/13.92)	............SSI.Y...IAslLHVVRHCS...LCIKHAR...L..TSQMDALDI
  984- 1032 (92.98/48.44)	SYVEEVGLRSGSSNI.W...FR..LPLARGDSWQHICLRLGRPGCM..YWDVKINDQ
 1033- 1081 (53.11/24.77)	HFRDLWELQKGSNNTpWgsgVR..IA.NTSDIDSHI..HYDPDGVVlsYQSVEV...
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     378.21|     127|     345|      73|     333|       2
---------------------------------------------------------------------------
   73-  209 (189.27/292.05)	PLIQHCQQLASTVS....NHD.MCFTQAADSLFFMHEGLQQARapvYDVPSAIDILLTGSyqrLPKCvEDVGTQYALTEDQ......QKPALKKLDTLVRSKLLQVsIPKEFSDIKV....SDGTAMLrVVG......EFKVLITLGyRGHLSLWRIL
  421-  568 (188.95/79.76)	PDIEYKQKDDKCCSkdseGHEvLCVRAYGSSFFTLGINIRNGR...FLLQSSQNIVVSSA...LIEC.EEALNQGSMTAAEvfislrSKSILHLFASIGRVLGLEV.YEHGFNIVKIpkdaSNGSAML.VMGfpdcgsSYFLLMQLD.KDFKPLFKLL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     134.49|      41|     350|    1158|    1203|       3
---------------------------------------------------------------------------
 1158- 1203 (67.67/61.24)	LW.FSFGSSVLARFVVEWESGKEGCTMHVSPDQlwPHTKFledFING
 1509- 1550 (66.82/44.38)	LWlFAQLPDLLKEILGSILKENEGALLNLDPEQ..PALRF...FVGG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      79.09|      24|     344|     278|     333|       4
---------------------------------------------------------------------------
  283-  311 (38.57/59.04)	RFELISEGHgasssSAQNPDGESE.SSALR
 1658- 1682 (40.52/ 6.49)	RIELCLENH.....SGLNVDENSEsSSAFR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      79.18|      24|     617|     800|     824|       6
---------------------------------------------------------------------------
  800-  824 (40.00/25.30)	LNDTSNeALSGSRSSRLLSPP....RPTG
 1434- 1461 (39.17/20.38)	LNRVGN.ALAGSSNLALMTSPvslrRPPG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     128.28|      40|     617|     626|     709|       7
---------------------------------------------------------------------------
  664-  705 (68.52/91.18)	LEKGSSVAplSVQNV.PSSGNTSLPS....QYGSVPMNIHSLKAGS.P
  709-  754 (59.76/14.55)	WEGGMQMA..QVNNVtKASGATSLYSgslfSSGSVKGPVQSSSVGSiP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      99.46|      28|     183|    1279|    1306|       8
---------------------------------------------------------------------------
 1279- 1306 (51.43/28.49)	VMPT.ASGPTNQTLSMLAAAGRGGPGIVP
 1463- 1491 (48.03/26.10)	VVPAhVRGELNTAIIGLGDDGGYGGGWVP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.42|      16|     184|    1386|    1402|      11
---------------------------------------------------------------------------
 1386- 1402 (26.66/20.04)	FTGQQAGGlTNSNNPN.P
 1403- 1419 (25.76/14.19)	GSGSQMMA.ANGNRINlP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP33314 with Med14 domain of Kingdom Viridiplantae


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) EEQLRVLNDTSNEALSGSRSSRLLSPPRPTGSRMSIPNSRPNGPQADSFKVIGS
2) GPVQSSSVGSIPTGHVRNTAGKKLSASKSEQDLASPKSPHSVDISSSIAI
3) LSVQNVPSSGNTSLPSQYGSVPMNIHSLKAGSPSPKWEGGMQMAQVNNVTK
794
743
673
847
792
723










Molecular Recognition Features






MoRF SequenceStartStop




NANANA