<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP33266

Description Mediator of RNA polymerase II transcription subunit 5
SequenceMENPAAAGDAMRVAIDYWCQFVARCVSERLETDKFEAYVKIVHDQHPLPPTLVADFFLRPHPSDDSSLDPRIPPYLQVLTKLGYVDTPSILRALYKYSSSHAHAQTQKDHLQSNTEEGKGKEKEKATSDDKEKAEGKEDAQPKKNITRWRSSYWAEEVLFYRLTKSVVEGRAIQDSRTALEVAMIISKFMELFTTALPATAFAADMLEQQFPNGQLRDEMESSRAALVALLLRLCENNILVSAISKPLAKDVRKALSTSLASFLPALQLIPEIADKLELFRTEILASSDPADKKKQVANAAMDELLDSTVGLENFVVAPISVSNTRAGLYIYLNAALIGRPILDDHALFSYMSNKYGADIQSSAIDLVLASFDILANAVFRNEGQKDAHLLRSFLINKLPLLLYQLLPPGFSGTSAEFCITEALTHVDTSLFPTASLMFDESRNNNPYTESIREEFCAACVLHGLVQREHVERILGEISLSYEPSLQKHSKDKLVQDCLSDTDKIQGLVRELDKTDGNVGAVCQALVEVLRQSCHNKETMSLKLLCSQLAAKPQSLDVILLFEKLPNILEPLCQLLDNWRYEEDQGEYQPVYEEFGAVLLLVFAFTYRYNLNAVDIGITTPDSWVAKIIGRGHVGRQGDELTQRENDHINGWVHGLFDTEAGGLGDELMSSCPPQEFYLVVAPLFQSIVVAYTYGYLNDESLKGGIEYLVDTFLLPSLVPAIRFLADYLWIDQKEQKSIIKILQLILLPSSISGEASTMLSSVKNLIAKPLEHALRTYQRRDPKNQDIEPLLRTLKESIPLSRRTGGTDLNELESWTATPPSGLSSAVKLTIQGLVHWSIHPAMNSMPTSYTHRQILAGLKLLGPKRLLHVILEELRQHTAAGSANIIYDVATSLVCAPDAVKDAPVTDANGNMLPPIQRQRTLRDLLKVEVESCRRLQKEDPVLAEHVVRLHRRVEAQMVIPQPQGMLQPADMSLNLADDTAALGDAMAAAASGVQGDNMSVDNLALDVSMGGVPSDMGLGSATDGGSLDPSGDAAMFEGFDTQDMENFDWDMNSFS
Length1058
PositionTail
OrganismGibberella zeae (strain PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084) (Wheat head blight fungus) (Fusarium graminearum)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Hypocreales> Nectriaceae> Fusarium.
Aromaticity0.07
Grand average of hydropathy-0.153
Instability index43.41
Isoelectric point5.03
Molecular weight117131.21
Publications
PubMed=17823352
PubMed=20237561
PubMed=26198851

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP33266
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     118.09|      38|      47|     489|     526|       1
---------------------------------------------------------------------------
  489-  526 (63.52/50.68)	HSKDKLVQD..CLSDTDKIQGL..VRELDKTDGNVGAVCQAL
  535-  576 (54.58/42.31)	HNKETMSLKllCSQLAAKPQSLdvILLFEKLPNILEPLCQLL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      36.71|      10|      27|     678|     687|       2
---------------------------------------------------------------------------
  678-  687 (18.25/ 9.69)	YLVVAPLFQS
  708-  717 (18.46/ 9.88)	YLVDTFLLPS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     145.70|      48|     134|     219|     271|       6
---------------------------------------------------------------------------
  219-  271 (71.67/57.67)	EMESSRAALValllrLCENNILVSAISKPLAKDVRKALSTSLASFLPAL..QLIP
  359-  408 (74.02/48.83)	DIQSSAIDLV.....LASFDILANAVFRNEGQKDAHLLRSFLINKLPLLlyQLLP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      67.80|      20|      25|     985|    1004|       7
---------------------------------------------------------------------------
  985- 1004 (33.20/16.94)	LGDAMAAAASGVQGDNMSVD
 1012- 1031 (34.60/17.93)	MGGVPSDMGLGSATDGGSLD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      41.37|      11|      23|     810|     820|      14
---------------------------------------------------------------------------
  810-  820 (19.67/12.24)	LNELESWTATP
  832-  842 (21.70/14.27)	IQGLVHWSIHP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP33266 with Med5 domain of Kingdom Fungi
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