<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP33265

Description Uncharacterized protein
SequenceMAQEKCGSKVWLKDLANSAIPLRKLSRSIPHGVRNKVLLDQCLNKNVPIDRAVWLAKCVGTNELRTFRRLGKGNNASVLEGERKWLKDWTLVIENFIERVFFSFGEQNWKAKVNYAIQLAAHLYAEGLMDREHYLDWTVSSLESSHHSQLPMWIIIAQIYWKDLLRLRKYGRRLATALISHYHVIHAHEDRDIYVPLLSKLSHLLGTLMVATPENFVSPSVWVKYRDALKTCLPQGDEARHRSFAGINYRNEQLVASANRSQPAARIILVRNLDQVILEKPMPDEFPAQCWTVSKDKAALVRALLEWCTTPYRPGLAKVYVAHRILMHWSTLRLDVTSAVLGFMEGEALEEMECKDALYHLVSELVRSGIFLVSQYIQWLITRGGLTDPQLVMPDGPPFSRLLAELPSHILGSSQKRSRDALLRRAGFRIADDAQDADMAIRHLRHALGLPAGVTDAVSMGRPFPIKKIARRIEDASRARKAEIASWLRNTVFGGELEHSSLNAFGQHDLSTRLFNSIRTVFEAAQEFSVFADVLRMLTKCSNPEVLASIADTITRYTFVFAALSCLKNLFSILHSRLREVQEQGIGARPLLASLAYLASRVPGMDEVAMQLKSDLAVSDRHNPVDACSPVSDNMVSRLSDHDGDLHEEVEKLLANGTSLDRNTMDRLFSAVIQRLQAYWSKGDEQQRVYGILLKRLRMFNPQHFDELMTRWLLYVRGLDTRATILHLYPLLVSIGCLEMPAILATASESPNALGAGNSRHPQSAVATSQIVQTTFRTRYMQEVLQLFMAPVSSESLLTPEERYRFGILQEQAKKESPRELLCLIQLALAEYTCARAQNDLEELPLDKEANQDRLLRLLKLLVLKDPVGVAKALQIRGPDAQIDGWIDRMTTKLLVTAAGEGTRVTFEQVLNLTNEFTLPFCHVKLLLSLSSNDQQQNAADSGERVPSNVELFMNAMEKSMDAQRVSWIGMLPSLSPDLTHHLKNQAQARFLNLLPSARNPPSMTLDRSMLQMRLQKAENFLAIMDTIIRGSGPMGFRQHQLVPVMVERFTDILELLQTLTPFPSQAGGLGGWGGQGASAAAAGGDSHIDLKSDILNHWLPLFLNFLTLHAQTFDTSKPGNEVRGRALMVCAGLIRELDLIHGPDFDTRQLGGRIFDLACVLVDNLAEDARLQCIQALKSPSDVKLRYIFSYQDNPHANLMLCHKERPTAMAIGTATGTGSPAPGTTPTHTPGVTPGPQNAVGAGSAVSGAGGSGNGGSYFSLPGHTQQAQAQGWHAAQQQQQQQQQQQSQQQQQQQQQQQYQLQQQQQQGGTGPIPSPAISINTNLTHLNLGNNSNPPTPSPMNPTRPAMMMVANPWGGYSWVPTMGGPQERLTPFNFRQWEMLSEPTSQVGENDTAVNLMLFESRKVQ
Length1410
PositionKinase
OrganismNeurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Sordariomycetidae> Sordariales> Sordariaceae> Neurospora.
Aromaticity0.07
Grand average of hydropathy-0.243
Instability index45.04
Isoelectric point8.27
Molecular weight157298.40
Publications
PubMed=12712197

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. Component of the srb8-11 complex. The srb8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The srb8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
ECO:0000256	ARBA:ARBA00002895
ECO:0000256	ARBA:ARBA00003744
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP33265
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     223.17|      70|      84|     998|    1072|       3
---------------------------------------------------------------------------
  998- 1072 (104.50/89.92)	ARNPPSMTLDRSMLQMRLQKAENFLAIMDTIIRGSGPMG.FRQHQLvPVMVERFTDiLELLQTlTPFPSQAggLGG
 1083- 1153 (118.68/80.26)	AGGDSHIDLKSDILNHWLPLFLNFLTLHAQTFDTSKPGNeVRGRAL.MVCAGLIRE.LDLIHG.PDFDTRQ..LGG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      78.54|      16|      18|    1279|    1294|       4
---------------------------------------------------------------------------
 1268- 1283 (30.60/20.08)	QQAQAQGWHAAQQQQQ
 1284- 1299 (32.31/21.67)	QQQQQQSQQQQQQQQQ
 1300- 1310 (15.63/ 6.29)	QQYQLQQQQQQ.....
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     117.16|      38|      45|      10|      54|       5
---------------------------------------------------------------------------
   13-   51 (60.35/57.92)	KDLANSAI.PLRKLSR....SIPHGVRnKVLLDQCLNKNVPIDR
   57-   99 (56.82/30.04)	KCVGTNELrTFRRLGKgnnaSVLEGER.KWLKDWTLVIENFIER
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      92.34|      30|     153|     201|     271|       6
---------------------------------------------------------------------------
  201-  233 (43.77/77.93)	LSHLLgtLMVATPENFVSPSvWV..KYRDALKTCL
  273-  304 (48.56/12.29)	LDQVI..LEKPMPDEFPAQC.WTvsKDKAALVRAL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     106.54|      32|     588|     375|     408|       8
---------------------------------------------------------------------------
  327-  363 (49.05/22.26)	MHWSTLRLDVTSAVLGFMEGEALEEMeckdaLYHLVS
  377-  408 (57.49/27.19)	IQWLITRGGLTDPQLVMPDGPPFSRL.....LAELPS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      61.90|      17|      22|    1317|    1338|       9
---------------------------------------------------------------------------
 1317- 1338 (26.76/23.62)	PSPaisinTNLTHLNLGNNSNP
 1341- 1357 (35.14/19.21)	PSP.....MNPTRPAMMMVANP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.62|      17|     518|     158|     174|      11
---------------------------------------------------------------------------
  158-  174 (33.21/22.33)	QIYW.KDLLRLRKYG...RRL
  677-  697 (24.42/14.39)	QAYWsKGDEQQRVYGillKRL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP33265 with Med12 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) TAMAIGTATGTGSPAPGTTPTHTPGVTPGPQNAVGAGSAVSGAGGSGNGGSYFSLPGHTQQAQAQGWHAAQQQQQQQQQQQSQQQQQQQQQQQYQLQQQQQQGGTGPIPSPAISINTNLTHLNLGNNSNPPTPSPMNPTRPAMMMVANPWGGYSWVPTMGGPQERLTPFNFRQWEMLSEPTSQVGENDTAVNLMLFE
1209
1405










Molecular Recognition Features






MoRF SequenceStartStop




NANANA