<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP33264

Description Serine/threonine-protein kinase prk1
SequenceMMYGTNRARNQKAETSYRGYQRSNAGPLNYQTKVRITDRYKVIGFISSGTYGRVYKATGRQGQTGEFAIKKFKPDKEGEAVVNYTGISQSAVREMALCSELRNHANVIRLIEIILEDKCIFMVFEYAEHDLLQIIHHHTQTPRHPIAPGTIKSIMYQLLQGVQYLHTNWVLHRDLKPANIMVTSSGEVKIGDLGLARVFKQPIHNLYMGDKVVVTIWYRAPELLLGSKHYTTAIDLWAVGCIFAELLSLRPIFKGEEAKMDSKKTVPFQKHQMQKIVDVMGLPTRERWPLLASMPEYSQLSTLQPPLLSTNTSHSHGGGHHPYGHRSQQQPPASQNTHGNLQKWYHQTTVSTPLTSLGAEGYKLLASLLEYDPEKRLTAADALVHPFFTSPTSTPLASLNSNTANSTSQGTGAAAVNWSPTNCFEGLKNETYPCRRVSQDDNDIGFGTGTGNQSGSRVNTAAAGTGTGLVMGQAQSQVQAMGGSLGNIGGHGHGHGHGQMGGGGMGQGMGGLGQGHGGMAQMAGMKRMHDAAAAAAAAAAAAVQQSHPNKRMKGSQG
Length557
PositionKinase
OrganismNeurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Sordariomycetidae> Sordariales> Sordariaceae> Neurospora.
Aromaticity0.07
Grand average of hydropathy-0.420
Instability index34.54
Isoelectric point9.44
Molecular weight60398.80
Publications
PubMed=12712197

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IBA:GO_Central
nucleus	GO:0005634	IBA:GO_Central

GO - Biological Function
ATP binding	GO:0005524	IEA:InterPro
cyclin-dependent protein serine/threonine kinase activity	GO:0004693	IBA:GO_Central
RNA polymerase II CTD heptapeptide repeat kinase activity	GO:0008353	IBA:GO_Central

GO - Biological Process
protein phosphorylation	GO:0006468	IBA:GO_Central









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP33264
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      84.48|      16|      16|     468|     483|       1
---------------------------------------------------------------------------
  468-  483 (28.45/13.13)	GLVMGQAQSQVQA.MGG
  486-  502 (28.04/12.83)	GNIGGHGHGHGHGqMGG
  510-  524 (27.99/12.79)	G.GLGQGHGGMAQ.MAG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      81.36|      21|      23|     301|     323|       4
---------------------------------------------------------------------------
  301-  320 (24.52/15.98)	......STLQPPLLSTNTShsHGGGH
  321-  342 (31.84/14.82)	HPYghrSQQQPP.ASQNT...HGNLQ
  343-  362 (25.00/10.18)	KWY.hqTTVSTPLTSLGAE.....GY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.81|      15|      15|     178|     192|       6
---------------------------------------------------------------------------
  178-  192 (23.86/17.29)	ANIMVTSSGEVKIGD
  196-  210 (26.95/20.52)	ARVFKQPIHNLYMGD
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP33264 with CDK8 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) CRRVSQDDNDIGFGTGTGNQSGSRVNTAAAGTGTGLVMGQAQSQVQAMGGSLGNIGGHGHGHGHGQMGGGGMGQGMGGLGQGHGGMAQMAGMKRMHDA
2) LQPPLLSTNTSHSHGGGHHPYGHRSQQQPPASQNTHGNLQKWYH
3) SPTSTPLASLNSNTANSTSQGTGAAAVNWSP
434
303
390
531
346
420










Molecular Recognition Features






MoRF SequenceStartStop




1) HPNKR
547
551