<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP33261

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMYSVGNASTRACSDIAISEKVEVLEAMASALSIAPAAAAPVQAAEDILLSLPTLGSLAQPRQDAALTAGERVEVAEVLDPTRIAVGCHGSVVETLPSALTLWDKSKLSAVSGEKHVIAKVLLTDASPAWHDEIVAWLERLRVAFEAHGLGTHSGGPQSILAVADGSDSLALSSYLDELYKDGETWLDTLRSISSRVQLDLLQGKHVVVYTLQPLHSSPCGATGYHGLLRLEADLRAMLSEQVGVLAEQLLAHDGDMEDSTLYDASNLSILDKMADAAQSPSTTGASIVVLSAVDERGGSSAVDAFSVPEGSSNVEACIERVWRFAVAEASRARLNWRLAISSAGSMRRRELRAWQRLIDAYLTASGAQERVMGSVVLLSVRPDDSGAILTERGVRIKASQDWATSTTAAASDKASLILLDAADFSQMVKFAEPMPMGWTEAFGSSHSSKEEEGAGTELDMMAMPIASAMLVHRPRQDFVSSGNNVGLDGRLGASHVLAIDMLQSWNLSPSQQTRPLSEEAATREQSRKEVEDMDSILRSLHRLRLISEERHHLPWPYNAQPWPVASVNTLASCLDGVMLID
Length581
PositionKinase
OrganismKalmanozyma brasiliensis (strain GHG001) (Yeast) (Pseudozyma brasiliensis)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Basidiomycota> Ustilaginomycotina> Ustilaginomycetes> Ustilaginales> Ustilaginaceae> Kalmanozyma.
Aromaticity0.05
Grand average of hydropathy-0.037
Instability index48.47
Isoelectric point4.93
Molecular weight62291.65
Publications
PubMed=24356824

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP33261
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     191.74|      45|      87|     254|     298|       1
---------------------------------------------------------------------------
  254-  298 (71.43/42.05)	GDMEDSTLYDASNLSILDKMADAAQSPSTT..GASIVVLSAVDERGG
  344-  386 (64.80/37.47)	GSMRRRELRAWQRL..IDAYLTASGAQERV..MGSVVLLSVRPDDSG
  411-  453 (55.51/31.06)	SDKASLILLDAADFSQMVKFAEPMPMGWTEafGSS...HSSKEEEG.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     163.03|      40|      42|      53|      92|       2
---------------------------------------------------------------------------
    7-   42 (40.14/17.27)	.....ASTRACSDIAI..SEKVEVLEAMASAlSIAPAAAAPVQ
   53-   92 (65.36/31.88)	TLGSLAQPRQDAALTA..GERVEVAEVLDPT.RIAVGCHGSVV
   94-  134 (57.53/27.34)	TLPSALTLWDKSKLSAvsGEKHVIAKVL.LT.DASPAWHDEIV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      39.57|      14|     161|     160|     173|       5
---------------------------------------------------------------------------
  160-  173 (21.79/10.22)	LAVADGSDSLA.....LSS
  305-  323 (17.78/ 7.10)	FSVPEGSSNVEacierVWR
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP33261 with Med13 domain of Kingdom Fungi
Unable to open file!