<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP33255

Description Mediator of RNA polymerase II transcription subunit 5
SequenceMGTAVEQWRKLLHQCLIQRIDANEFKSLSKLLLRRCPLPEATLLDVVLESRTVTDVQWDPLLPLYVDSLAKLGHVKISTVLSSALKYSTIVDSKPGSPAAAGGTAPAGEEIKKKGRKVSSSLMTDIRLIQDAMMAISAGFSPKTAAEAVNIFSAVAEWILAVVAWHNGNVDEQHQTGGLMNSPDGMTLFESLGILLAALSATGKALEALAMGNSEAWKVKLGQALSAYLPLCAGVSLPLRNRLDSLQKEFNLYGESASKTLEVSMMDGVNVNALHFEDSVIDGPVVNSRAGLYVFVNAMLVGRPLVDDSMLINYLTNRYGGHHGVLVEELITAAFDVLSNAMYRNESSRTMFVFRSFLVNKLPSFFASMSAASMQPIPMELCISNALNRVDPNAFPSFSQMFAMQGNTVLSDVRQEFLFACATHKLIPESSIERLLGENPMQTLSASGQYVKDELVSQINANPERAEHLIGEIESMEGNAGAIVVAITEVMHNLCNQKETMTLKNICNSLSRRPQALDVILLFRSPKTVLQPLCALLDAWHWDEDQGESQPVYDEFGSILLLVLAFKHRYNLSQYDMGISTNNSFVLTLLDRGPCSQKLDDLNESQHKNLGAWISALFIAEGISEESMSSCSPQEFYLLVATLFNQSLGACEAGKLEFDTLKGGFEYLLEPFLLPSLVVALTWLGNYIWESESDPTIPLKVLHSLVKPSSISGEAQAIHRTVLQITARALEEQLKDVRTRQPSRADIKPILDALEPYLSFQRTGSCHRSELEGWMTNSGGGLLGSIRNTFQSLVLWSTNPEISMTPHSYTHRQILAGIRILGASRVLPALIEELKLQTEAGSGDLALDVAATLVCSPMAESFAVEQSFYHPIDPNKDALPRCPILTLRDALIIQHDDVPKISEKDPLRAEVLVRLYRRVNSVMAPPSQVTNLDVSNIIQNMNLGGVGEHGQMGLGPGEHGVGQGGVGDEDPENINQMLNEAAAAAAAGVDNDVGQGMGLDSSGAGLHANIDDMLNSADMGVGNPEFLDLDMEGMF
Length1035
PositionTail
OrganismByssochlamys spectabilis (strain No. 5 / NBRC 109023) (Paecilomyces variotii)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Thermoascaceae> Byssochlamys.
Aromaticity0.06
Grand average of hydropathy0.003
Instability index42.65
Isoelectric point4.95
Molecular weight112637.52
Publications
PubMed=24407650

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP33255
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     107.50|      24|      43|     750|     773|       2
---------------------------------------------------------------------------
  729-  749 (26.56/12.98)	...ALEEQLKDVRTRQPSRADIKP
  750-  773 (41.44/24.01)	ILDALEPYLSFQRTGSCHRSELEG
  794-  817 (39.50/22.57)	VLWSTNPEISMTPHSYTHRQILAG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     140.17|      44|     331|     516|     611|       3
---------------------------------------------------------------------------
  471-  514 (75.25/27.20)	GEIESMEGNAGAIVVAITEVMH..NLCNQKETMTLKN..ICNSLSRRP
  547-  594 (64.92/120.83)	GESQPVYDEFGSILLLVLAFKHryNLSQYDMGISTNNsfVLTLLDRGP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     100.87|      34|     331|      25|      80|       5
---------------------------------------------------------------------------
   33-   71 (49.82/52.86)	LRRCPLpeATLLD.VVLESRTVTDV.QWDpllPLYVDSLAK
  879-  914 (51.06/24.60)	LPRCPI..LTLRDaLIIQHDDVPKIsEKD...PLRAEVLVR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     128.49|      43|      49|     372|     418|      12
---------------------------------------------------------------------------
  372-  418 (62.62/54.35)	ASMQPIPmELCISNALNRvDPNAFPSFSQMFAmqGNTVLSDV.....RQEFL
  422-  469 (65.86/40.97)	ATHKLIP.ESSIERLLGE.NPMQTLSASGQYV..KDELVSQInanpeRAEHL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.78|      14|      34|     973|     991|      14
---------------------------------------------------------------------------
  973-  990 (19.64/18.62)	NINQMLNeaaaAAAAGVD
 1009- 1022 (26.14/10.29)	NIDDMLN....SADMGVG
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP33255 with Med5 domain of Kingdom Fungi
Unable to open file!