<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP33251

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMDFPANTITNIHVIDGFSNIYWRIYTEEPASAALPAEGPANGFTILKHLSRLKSLELRLRNFDCLVSCYPRRLGLWVFSATPDFGTLKPLSRDGDGTNYNRLALDSVNLKVAAAGTVTAADLMRSMSTDPQPSNPNASGAQRSLSAGRPGEGQGNQGIIYAAFVSAVTSAMCLQLVRRHNAIPLGSRTLFTAVDRNGYDGPILHDSPVSVPSLTTLRIELTPLGKLIISLHTISQHGITRLWDAARNTIGPSLEPGQDIWLAPTGTIARLISAESEEGSLPSPGLSNSRTSEDAKSQHLLALKRQNWKENVVEWLGNVGLPLSSPEDESWVEVEVPEPFYSRLAAESMRQSDGTQPSPPLRRLLWPAKYSFTRTKTASPSETFTFDRCDPIDFAAEWFATASTRNEKLASSKATGGSPGPQPKGPEMSTPRTDTGEVVESLARVNQYPDLQAASLVYPTPPDGALAQGFNNVQPSDGFLEVPDAAAPSNIGNSGGVKPGNEEVADARSGPDSMGELGTSATLGVGSGLYDANDDDDLFEEMNEKDFGSKGITDADFSFFDEPDMAGFDDNKQTDHATQQGSAQVSLPTDSIKPPETATSEIAVDTSVERAKLSLDGEHGTEPATDVEEPKQNLMEIDGEKIEDNTHTDIPDHNPPADEVQTVSPPLSPVKIKRILFSDPQSKESSQVDTSSTTRPLPKDGRNHGHYGPVPFQQELSSWDRKYGAAGTFSVSIHKAAKTQPAVGDSTSTIPTIGLPRRGRSKSLKSAFPKSTTLGQDTAMSDGGPVLNSTSASSDETTDDSDDDYLEKPASPMRSTAVKRKRGVSETDNDSIIPQEKASLAIGPDPSVLKEENSTFLGNFFYIFSDWSLAGYFSIRQNRLSPTLVRKEESVQLAQLMVDQVTQSSLTHKLDERIGLADLGNDTFALRTFLEDSSVMGEIARLDLKSYVEIQQSEASTVPEGQALRQKSLPIKGTISKLPTPHLRIRRGKDYLEVLPPAISFWETFGLEPAHGEKDITAYCIHPEYAIEGANAFVERLGLLYSSCGLGKHARGADTKEFESELGSWKVETSLSGYASTMQNLKAICERLGNILAKRRPTKDNYVIYIINPFENVAALADICAAFLHLFQKYIGAADRQDTRQLNELVLQIVPMSFIWSPLWVVVPTQSEYLNLALEVYNRCPPRDPASGSMGCAPPLLLAEPTPRSINFKLISERISPLQEGKCLHISFSRSIDQRWVTVAWSDSTGSFQVALSYCLRSKGSSVARSISEVRHEIWETTKDIIDRTQARWRVLLVKTEPVDQEEIEAWTTLAERYNQTRPVPVELTIFSADTTPDLYLELPPSQIQVQFLNAQSTSTPVATPNPSAPSPDPLGTAATPTSGGNAVASAPTPTDLQPVEPDSDTVLVDICDESWGVVLSHRLNNSPHLTEYRPALASGYLLRRKGTYDGDGAFAMTLNLIYTQRPAASHELLLREVLGMYRDLATLARSQGIASIQRNTLPWHIATAIRGQEMLSYVL
Length1515
PositionKinase
OrganismByssochlamys spectabilis (strain No. 5 / NBRC 109023) (Paecilomyces variotii)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Thermoascaceae> Byssochlamys.
Aromaticity0.07
Grand average of hydropathy-0.389
Instability index50.28
Isoelectric point5.05
Molecular weight165126.88
Publications
PubMed=24407650

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
ECO:0000256	RuleBase:RU364134
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP33251
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     233.53|      85|     287|      50|     153|       1
---------------------------------------------------------------------------
   31-  132 (126.10/87.97)	SAALPAEGP.angftilkhlSRLKS.LELRLRNFDCLVSCYPRRLglwvFSATPDFGTLKPLSRDG.DGTNYN....RLALDSVNLKVAAAGTVTAAdLMRSMSTdpQP
  145-  205 (55.81/34.87)	SAGRPGEGQgnqgiiyaafvSAVTSaMCLQLVRRHNAIPLGSRTL....FTAVDRNGYDGPILHD............................................
  692-  740 (51.62/17.82)	.........................................................TTRPLPKDGrNHGHYGpvpfQQELSSWDRKYGAAGTFSVS.IHKAAKT..QP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     152.54|      36|     343|     947|     996|       2
---------------------------------------------------------------------------
  947-  982 (57.06/21.56)	VEIQQSEASTVPEGQALRQKSLPIKG..TI.SKLPTPHL
 1298- 1334 (52.00/18.42)	VDQEEIEAWTTLAERYNQTRPVPVEL..TIfSADTTPDL
 1354- 1389 (43.47/17.96)	STPVATPNPSAPSPDPLGTAATPTSGgnAV.ASAPTP..
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     108.59|      30|     343|     833|     862|       3
---------------------------------------------------------------------------
  833-  862 (53.03/27.91)	PQEKASLAIGPDPSVLKEENSTFLGNFFYI
 1181- 1210 (55.57/29.60)	PRDPASGSMGCAPPLLLAEPTPRSINFKLI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     177.34|      49|     286|     324|     379|       5
---------------------------------------------------------------------------
  272-  310 (50.27/21.26)	SAESE...EGSLPSP...G.LS.NSRT.......SEDAkSQHLLALKRQNWKEN.......
  324-  375 (83.75/51.41)	SPEDEswvEVEVPEPFYSR.LAAESMR.......QSDG.TQPSPPLRRLLWPAKYSFTRTK
  390-  433 (43.33/25.27)	............PIDFAAEwFATASTRneklassKATG.GSPGPQPK...GP.EMSTPRTD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      65.63|      20|     627|     863|     888|       6
---------------------------------------------------------------------------
  867-  886 (36.17/27.22)	SLAGYFSIRQN......RLSPTLVRK
 1069- 1094 (29.47/ 6.49)	SLSGYASTMQNlkaiceRLGNILAKR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     122.54|      28|     412|     499|     526|       9
---------------------------------------------------------------------------
  487-  514 (47.32/25.49)	PSNIG..NSGGVKPGNEEVADARSGPDSMG
  515-  539 (37.75/18.82)	ELGTS..ATLGVGSG...LYDANDDDDLFE
  540-  566 (37.47/18.63)	EMNEKdfGSKGITDADFSFFDE...PDMAG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      70.26|      22|     412|     231|     255|      11
---------------------------------------------------------------------------
  231-  255 (31.35/26.18)	HT.ISQHGITRlwDAARnTIGPSLEP
  646-  668 (38.91/19.97)	HTdIPDHNPPA..DEVQ.TVSPPLSP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      33.22|      10|      32|    1222|    1231|      12
---------------------------------------------------------------------------
 1222- 1231 (19.93/17.24)	CLH...ISFSRSI
 1254- 1266 (13.29/ 8.27)	CLRskgSSVARSI
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP33251 with Med13 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) DLQAASLVYPTPPDGALAQGFNNVQPSDGFLEVPDAAAPSNIGNSGGVKPGNEEVADARSGPDSMGELGTSATLGVGSGLYDANDDDDLFEEMNEKDF
2) NAQSTSTPVATPNPSAPSPDPLGTAATPTSGGNAVASAPTPTDLQPVEPDS
3) RNEKLASSKATGGSPGPQPKGPEMSTPRTDTGEVVESLARV
4) SFFDEPDMAGFDDNKQTDHATQQGSAQVSLPTDSIKPPETATSEIAVDTSVERAKLSLDGEHGTEPATDVEEPKQNLMEIDGEKIEDNTHTDIPDHNPPADEVQTVSPPLSPVKIKRILFSDPQSKESSQVDTSSTTRPLPKDGRNHGHYGPVPFQQELSSW
5) SVSIHKAAKTQPAVGDSTSTIPTIGLPRRGRSKSLKSAFPKSTTLGQDTAMSDGGPVLNSTSASSDETTDDSDDDYLEKPASPMRSTAVKRKRGVSETDNDSIIPQEKASLAIGPD
449
1349
404
557
729
546
1399
444
718
844










Molecular Recognition Features






MoRF SequenceStartStop




1) DFSFFDE
2) LRRLLWPAKYSFTRTK
3) PVKIKRILFSD
555
360
668
561
375
678