<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP33239

Description Uncharacterized protein
SequenceMIPHSSAGVQPWAHQSHALNNNSARSLDGVNIADRAPFAAEKLPGAVSMPQSEQTVIDLTSGESAAQENERPAKRQKLDASTGPNVRSTEGKSVSSPAAWRSAPLAHRARPAWSFQELVSETNPGNSTANDSRNPPSALPFPIRPWKYTPLRQGGNTGGSRENSPDRQVQTTPYHLDTPSVAPVLKGEKVADFSPWTGNHPEDVLNEQAAKQGHYDRTQVSQNESNTARPSLYAQLRHRSGLQVLSSVFAAALEKRQTSSKLSAASTFKPPPRVTLTDNKREAWLRDLANPNVPLRRLSRTIPHGVRGKLLLDQCLSKSIPIGRAVWLAKCVGANEIRAFKRKGTSGSLALGLEVKWIRDWTTNVHLFIEGVLPSCGNPQWKAKVAYAVRLTARLFFEHLLDQDQHLDWFLYSLEAASLDDLPIWLMILGVYWSSIVPFRRRGRKLMEILLEKLRHSSQTAQEGLMKPMSHRLAHLVRKLVYEQCSSAVIPRSWDKYRTVMSSCLATSAADETVFRTIAGRNAYLQCSKGPSKVSERSPLRQIVISLDSACSTHDINATSQACLSVIDDKEVLIARVLEWCSTSFRYGLVRVYIAIRLLRKWKRLGMDTDHHIFAFLLTAKKQVRLHIENVYHVISELVRSQTFSVGRYLQWLIAKGIIDSGQENGHQEVYPYVELLRHIPVGRLPEHVRSLRNTLMLRAGFHPSDEGPTIDALKSLIRPLLPEIFGYNVRADTDYLDNKLLLNQTHAVRTEIGQWIRTGVSGRLRSTPLRGCHGHHSSHLDEVASLTPDEFYTVRSIMETFGDLSMLADILNDIASSDNVIVLASVVDTLNYHFDSFTVIGAMMGLWRRSVDAWSRVKSVGLSTRELVYSLVELGLRLPTEASTVAVLRQELFRLDCRSTLTASSPMSDHMVDTINSERWTSNEDLDQLLSSAAGMEESTLATVFGTLSKRLELAGSADGNLALDDTCRHLVQLRSFNSKLFDTLLIKWIVQIIKSTPRPRLSKILIPLIGVGCVTLKGFFALARKLLQLDTSAAISGLIMLRLELLELLCPLLPTHRDAHNLIAYRFAIAQQEFLSKNSEDILDMIRETGDSFATYAPSDSTEATLLSFYACSVPLLCDLLIRNPQSVVERCVQKLCCGESQPTVHAVQKALNMLLGFGDKSGALVSIHHTCIRSDFGRGTGSTLTEAESTLGAANDFSLSFCQMKLQVLFNAESGEGTKNDIIDVIFRAAVADIQAKRSNWVDMVITMTTEVAQQIRQRAERGFLSVALSDSPTGETRVDELSAQDMAMVYLTIVEELAYSIPDTGVPSIAQLLTEKMTILLNKHIALQNSVRHFPRNDGTLATDEIETTLSTFGRHSAFWVTTLLKMTVIHCSAFTSSSAAGKSSLLDQTRLLVTICIIATLQCPSDLIPESQSAGHLSEKQREPSHRGLQTYAFDVAACLVDHLPEDVRQQCTRFLKERCPSSLHVRNNPRLLYLLGPVADLGTFTQPQAAVGSPPTTSGSACTPSSSSSNVGTGTSAGLQSSQPVMAFAGPFEDQTHAANRLRIQNRGRVVGVYPFRPWEMLEEAAPVLGINDTAVALGFFSARKTTELQ
Length1596
PositionKinase
OrganismByssochlamys spectabilis (strain No. 5 / NBRC 109023) (Paecilomyces variotii)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Thermoascaceae> Byssochlamys.
Aromaticity0.07
Grand average of hydropathy-0.162
Instability index46.75
Isoelectric point8.49
Molecular weight176407.38
Publications
PubMed=24407650

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. Component of the srb8-11 complex. The srb8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The srb8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP33239
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.43|      15|      18|     298|     315|       1
---------------------------------------------------------------------------
  306-  321 (22.86/21.07)	VRgKLLLDQCLSKSIP
  477-  491 (26.58/11.56)	VR.KLVYEQCSSAVIP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.68|      16|      18|     233|     249|       2
---------------------------------------------------------------------------
  234-  249 (27.39/19.15)	AQLRHRSGLQVLS..SVF
  251-  268 (21.29/ 7.29)	AALEKRQTSSKLSaaSTF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      70.30|      19|      19|    1351|    1369|       3
---------------------------------------------------------------------------
 1338- 1354 (21.08/11.38)	..FPRNDGTLATDEIETTL
 1355- 1373 (33.31/23.05)	STFGRHSAFWVTTLLKMTV
 1377- 1391 (15.91/ 6.45)	SAFTSSSAAGKSSLL....
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      40.82|      14|      19|     572|     589|       4
---------------------------------------------------------------------------
  572-  589 (22.30/22.15)	VLIA.RVL.EWCstsfRYGL
  592-  607 (18.51/ 8.11)	VYIAiRLLrKWK....RLGM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.27|      17|      18|     972|     988|       6
---------------------------------------------------------------------------
  972-  988 (26.99/17.13)	LVQ.LRSFNSKLFDTLLI
  991- 1008 (23.28/13.68)	IVQiIKSTPRPRLSKILI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      36.03|      11|      17|    1020|    1030|      10
---------------------------------------------------------------------------
 1020- 1030 (18.34/11.81)	GFFALARKLLQ
 1039- 1049 (17.69/11.10)	GLIMLRLELLE
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP33239 with Med12 domain of Kingdom Fungi
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