<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP33237
Description |
Mediator of RNA polymerase II transcription subunit 6 |
Sequence | MAESQDAALEEILWRSPPHVQMMGGYLHSNNILFYFAESPFFDPTSNNASLAIQASYNETFRHFVETREAFEGRLKTMQGLEFIVSYDPLQAAAQTDGTFAHEPSNIWVIRKQNRRKPPGMDDEVTVLSTYFVVGDTIYMAPSVASVVGNRLLSAVTSLTRLLNTASPLPIFSASYGHTYMPPLPKSTDATQSQQSKENTPMPDTHAQSKASLAGPAMSGSSWEDTRNLMESFSLLSKYGEEYMDENPLVGEPGNFILSRSSDAAAARQHNKPGTPASGAIGRVGTPSFGKGEVGKGPKAAEKEKEKTPGTPDADNKLKRKKSRVGIIAP |
Length | 330 |
Position | Head |
Organism | Byssochlamys spectabilis (strain No. 5 / NBRC 109023) (Paecilomyces variotii) |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes>
Eurotiomycetidae> Eurotiales> Thermoascaceae> Byssochlamys.
|
Aromaticity | 0.08 |
Grand average of hydropathy | -0.496 |
Instability index | 51.07 |
Isoelectric point | 6.20 |
Molecular weight | 35922.89 |
Publications | PubMed=24407650
|
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364143
|
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro
|
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro
|
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro
|
Interaction
Repeat regions
Repeats |
>MDP33237
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 58.30| 16| 19| 175| 190| 1
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175- 190 (31.42/15.95) SYGHTYMPPLPKSTDA
196- 211 (26.88/12.77) SKENTPMPDTHAQSKA
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 65.58| 22| 103| 128| 154| 3
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128- 154 (27.14/33.92) LSTYfvvGDTiYM..APSVASvVGNRLLS
236- 259 (38.44/24.77) LSKY...GEE.YMdeNPLVGE.PGNFILS
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 78.84| 24| 34| 260| 283| 4
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260- 283 (41.82/26.33) RSSDAAAARQHNKPGTP.ASGAIGR
296- 320 (37.03/22.50) KGPKAAEKEKEKTPGTPdADNKLKR
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|