<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP33231

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMIVDTKGKQKQIDLIEQIPLAQLEQELPLEEADLVSLAALVERLANYGYESLQNLAETLPSLPSSSKRAKIFNTALDVRKQFIKLLVLSRWSKDVADLQKSRNIIALLSEQQWQHEDVFAGLTDIRKILPNARMRNADLPTAIDVLQTGTYRRLPTSIKDMAVAPKPFTDDQALTIVSRLEDALRTRMACRELVPAPLSNYSIRDGKVHFRVQGLFEAQLTASSGGQDTEVDAHIQSGLSTADTLATSPDDDRWWLLDLSFDVTPTGSGAESSNRVYPRKPKKAYRERLRLWGDQELAPRSQSEDADDAKSTTGTVEGATTVEDSDTKAVSAEETTEAALPTTAEQDDTAAIKVAAERDAPLLRLFAFLQERSLHYQMHILQHQAYELCRLNWGSNLRIETGERPRRLTVHYWTQAQNAADATQKVEGPAVGGSIQITLVDLPDQAGASTTLAALFDHDSDASDPAPDAKSSLATVKRRGLQATWNAHSSILADSEASDLVVSPDSLDIEALLSLVIKRHTLALLRNLQRRILVSDHPVSRLLRPEDCALCVEHAQRKGDEFSTATEASSLSFLQIVLHAKNRQRVARSTSTTAAALPPLRLSVDPVTGRVLLDSEAATGSDSGASQQQAASFTASALATRSTYARLAESSDRINVSIDALFDVLYNLDVFARVEEWERMATYVGLRAVRKLNLRPQDLAKLGATASMPQEAAPQLFIPLRNSFPGYFLALQPSELSGVSIALVYVVQMMDALGAPSLTLQSIEWLDRAKIDAASKAGSEGSDDAFDLGAEVGSKRKAPPVGSQTAEVDASFGKKDLTMEELANVHSYCIALVSYFRVEQQLRMRGIPYLHVGSNTSRSSPPAKRQKRLSPVRSAPQAAEAQDDGLFEEQEGGEAALDSIATDPAEKSTEDGVDGVAALVPSLCLRATDLLGPAKAHLTKPNVSLRVCHWNDSDRSCVQMHIKLRMKSRRFRPLHEIVSSAPTADAHTTSPLTWIDFDNETSLLTLSTRDLDNCIPIFYAQWERVMRMVQLTREVLNASRAWQLRAVREGRSCKKPDELVELQRFEFDTLVASYGTIDRYGEERKLVVRVRWQDAKVEMQPFTNIPVTQIGGYTLEFGSMAKSDGLTEEAFDDAHAAANPHNVMAFELRRTVNVSARSAAISAPTYPNAERLVWKGFFKLLQETLPLVREIAPFASASLSDPTVPEVEIKSATWVRLRFADRYAVDVQLATRARLVVSDASRALFRSEMATTEAKEEEGLFGGSDLLNDLIAGKIPTAAEKSTVTVTPVESTALQFQPIPNMDLLMQRVATALQTGDAAKGKAGMRGVWDLRRALLVSLTPAEAGGSGTVLRRLIPMLVEAVVAEIGR
Length1368
PositionTail
OrganismKalmanozyma brasiliensis (strain GHG001) (Yeast) (Pseudozyma brasiliensis)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Basidiomycota> Ustilaginomycotina> Ustilaginomycetes> Ustilaginales> Ustilaginaceae> Kalmanozyma.
Aromaticity0.06
Grand average of hydropathy-0.253
Instability index49.51
Isoelectric point5.56
Molecular weight150105.17
Publications
PubMed=24356824

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP33231
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     188.07|      62|      68|    1199|    1266|       1
---------------------------------------------------------------------------
 1199- 1266 (88.63/64.98)	LSD...PTVPEVEIKSAtwVRLRFADRYAVDVQLATRARLVVSDASRALfrseMATTEAKEEEGLFGGSDL
 1267- 1331 (99.45/56.91)	LNDliaGKIPTAAEKST..VTVTPVESTALQFQPIPNMDLLMQRVATAL....QTGDAAKGKAGMRGVWDL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.75|      17|      69|     698|     717|       3
---------------------------------------------------------------------------
  701-  717 (30.92/22.88)	KLGATASMPQEAAPQ...LF
  868-  887 (24.84/ 8.60)	RLSPVRSAPQAAEAQddgLF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     138.51|      49|      68|     538|     589|       6
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  538-  576 (55.14/29.35)	..........................PV.SRLLRPEDCALCVEH..AQRKGDEFSTATEASSLSFLQI
  580-  647 (53.78/33.02)	AKNRQRVARStsttaaalpplrlsvdPVtGRVLLDSEAATGSDSgaSQQQAASFTASALATRSTYARL
  648-  679 (29.59/ 9.13)	AESSDRINVS..............idAL.FDVLYNLDVFARVEE..WER...................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      82.62|      25|     254|     221|     259|       8
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  235-  259 (47.88/40.88)	IQSGLSTADTLATSP....D.DDRWWLLDL
  977- 1006 (34.74/ 9.28)	IVSSAPTADAHTTSPltwiDfDNETSLLTL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      94.95|      29|     325|      31|      59|       9
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   31-   59 (47.10/33.36)	EADLVSL.AALVERLANYGYESLQNLAETL
  359-  388 (47.84/34.01)	DAPLLRLfAFLQERSLHYQMHILQHQAYEL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.26|      15|     158|     303|     317|      10
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  303-  317 (25.24/18.46)	SEDAD.DAKSTTGTVE
  322-  337 (20.03/12.81)	VEDSDtKAVSAEETTE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.45|      20|      67|     116|     136|      12
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   93-  115 (27.87/15.73)	KDV.ADLQKSRNIialLSEQQWQH
  116-  136 (28.58/21.67)	EDVfAGLTDIRKI...LPNARMRN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     189.81|      61|     357|     746|     826|      16
---------------------------------------------------------------------------
  764-  826 (97.38/82.09)	EWLDRAKIDAASKAGSEGSDDAFDLGAEVGSKRKAPPVGSQT...AE..VDASFGKkdLTMEELANVH
 1124- 1189 (92.43/45.43)	DGLTEEAFDDAHAAANPHNVMAFELRRTVNVSARSAAISAPTypnAErlVWKGFFK..LLQETLPLVR
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP33231 with Med14 domain of Kingdom Fungi
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