<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP33224

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMRGRLTGYCPTDLVKQVYFRTSNGCVGLPHVSQGSGCQLNGQNCYVEVTMGCPRSGSDKASHINSNSLRNLHKHNVSESPSVGGGDPKGSPDNMSAYEKTFIYPAEAVLVPVLQTSFSRSSLRRFWLQNWIGPSMAGSSFLMHCFGNMDSLEGSWIETNGIHAQRGYNSSSNSNNSSISSISGSSSDSDYQMNARTGDLEADADSLTCRQSGLSSNDQLENEGPKLGSKRPRTGMIESFGQMGTGTNASTDFGSVENTSAITGVANDQIGPHWDWDDDDDRGMGMDIQALLSEFGDFGDFFENENLPFGEPPGTAESQSFMFSAPDCGDVGSSPVVAMDVSDQMLMPNFSSFESFNPLPTMAVEECMGKSQEVTNNTLTSGQANQSQASSTGEFDHLMKAEALMTFAPEYGAVETPTSELSSSIFRSPYLPKSYRVESSNSSSNNYVYGATPPGSPCFDGSDEKNGTPVSKACSGKHDSSALLHSKKYYSHVESSKEQNDRKSVTHKDSNAKSDGLVLSPFSNLSSTNAIKSLPRKMTEGTLGVEHIFLSKKTVLATEVECLMFQASMCRIRHVLLYSSNPSPISLSRFTGSTVLNQLPGDLSSMTESTSGRYELKKKESIPVRIAGDFDGGLLDGHLNAPVGVWRSVGVAKVSKPTNSSSIEVSPSMPHGSFTEEGMISYGQRQPLQELLDGLPLLVQQATSFVDVALDADCGDGPYGWLALQEHWRQEFSCGPSMVHAGCGGTLASCHSLDIAGVELVDPLSADIHASSVISLLQSEIRTALKSAFGSLDGPLSVTDWCKGRGQSVDAAALGDGSTESISECRDSSSTITVGEALSPSQSSGGGSSSLKVAMDGTKLDETGQRRLNQDIGSSESDHQLCARLKPTLFVLPSPAILVGYQDDWLKTSATSLQFWEKAPLEPYALPKPITYNVICPDIDPLTSAAADFFQQLGAVYETCKLGTHSPQNLGNQMEIDSGKSPSSGFVLLDCPQSMKIESNNASLVGSISDYFLSLSNGWDLTSYLKSLSKALKTMKLGPCSSTQQKEGNSGPCTVIYVVCPFPEPLAILQTVIESSASLGSVAISSDRERALLHSQVGKALSCPAAVDETSISNVLAISGFSIPKLVLQILTVDEIFRVTSPAINELVLLKETAFTVYNKARRISRGSSGDVVHSSSLSSRSHSVMNQMASIPGMWKDCVGSRMTGPSLSREGEIDASLRPGTWDNSWQATRSGGLNCDPNRNGDFLIQDEIRFMFEPLFVLAEPGSFDHGVSSTFNGNSTSDDSTGGFMMSGSTAGSADTGSSSQLDRSEQDGFGSGHHKSVPSLHCCYGWTEDWRWLVCIWTDARGELLDSHIFPFGGISSRQDTKGLQCLFVQILQQGCQILQTCCSPDSGVAKPRDFVITRIGSFYELEYLEWQKAIYSVGGSEMKQWPLQLRRSVPDGMPSSTNGASLQQQQEISLIQERALPSSPSPLYSPHSKASGFMKGGLGQPVGRKQLIGGHTMVDNSRGLLQWVQSISFVAISIDHSLHLVHQADSPSSGGTQGGNGVGPSGYLEGFTPVKSLGATPASYILIPSPSMRFLPPAPLQLPTCLTAESPPLAHLLHSKGSAIPLSTGFVVSKSVPSMRKDHKNKLKDEWPSVLSVNLIDYYGGNNISQDKVTRVIIKQGGRTASSEPKDFEVETHLILESIASELHALSWMTASPAYLNRRTALPFHCDMVLRLRRLLHFADRELSQQADNPQS
Length1742
PositionKinase
OrganismCitrus clementina
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> rosids> malvids> Sapindales> Rutaceae> Aurantioideae> Citrus.
Aromaticity0.07
Grand average of hydropathy-0.303
Instability index51.58
Isoelectric point5.33
Molecular weight187202.35
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP33224
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     643.68|     181|     225|     205|     395|       1
---------------------------------------------------------------------------
   87-  175 (70.30/36.67)	...............................................................................................................PKGSPDNmSAYEKTFIYPA....EAVLVPVLQTSFSRSSL....................RRFWLQNWIgPSMAgssfLMHCFGNMDSLEGSWIeTNGiHAQRGYNSS.....SNSNN
  205-  395 (296.50/226.90)	SLTCRQSGLSSNDQLENEGPKlGSkrP.RTGMIESFG....QMGTGT.NASTDFGSVENTSAI..TGVANDQIG.PHWDWDDDDDrGMgmdiqaLLSEFGDFGDFFENENLPFGEPPG.TAESQSFMFSAPDCGDVGSSPVVAMDVSDQML................MPNFSSFESFNPL.PTMA....VEECMGKSQEVTNNTL.TSG.QANQSQASS.....TGEFD
  433-  630 (234.40/155.77)	SYRVESSNSSSNNYVYGATPP.GS..PcFDGSDEKNGtpvsKACSGKhDSSALLHSKKYYSHVesSKEQNDRKSvTHKDSNAKSD.GL......VLSPFSNLSSTNAIKSLPRKMTEG.TLGVEHIFLSKK...TVLATEVECLMFQASMCrirhvllyssnpspisLSRFTGSTVLNQL.P............GDLSSMTES...TSG.RYELKKKESipvriAGDFD
 1150- 1208 (42.49/16.97)	.................................................................................................................KETAF.TVYNKARRISRGSSGDVVHSS..SLSSRSHSV................MNQMAS......I.PGM.....WKDCVG..SRMTGPSL........................
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     416.84|     116|     686|     773|     897|       3
---------------------------------------------------------------------------
  773-  897 (179.97/86.93)	ISLLQSEIRTALKS...........AF.....GSLDGPLSVTdwCKGRGQSVDAAA..LGDGST............ESISECRDSSSTITVGEAL.....SPSQSSGGGSSSLKVAMDGTKLDETGQRRLnqdiGSSESDHQLCArlKPTLFVLPsPAIL
 1246- 1320 (82.84/27.79)	..LIQDEIRFMFEP...........LFvlaepGSFDHGVSST..FNGNSTSDDSTGgfMMSGST............AGSADTGSSSQ.......L.....DRSEQDGFGSGHHK..............................................
 1458- 1586 (154.03/59.77)	ISLIQ...ERALPSspsplysphskAS.....GFMKGGL.........GQPVGRKQ..LIGGHTmvdnsrgllqwvQSI.....SFVAISIDHSLhlvhqADSPSSGGTQGGNGVGPSGYLEGFTPVKSL....GATPASYILIP..SPSMRFLP.PAPL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     123.39|      36|     493|     898|     951|       4
---------------------------------------------------------------------------
  905-  941 (62.47/89.00)	LKTSATSLQFWEKAPL......EPYALPKPITYnVICPDIDPL
 1024- 1065 (60.92/33.98)	LKSLSKALKTMKLGPCsstqqkEGNSGPCTVIY.VVCPFPEPL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.75|      13|     685|     414|     430|       5
---------------------------------------------------------------------------
  414-  428 (20.14/18.13)	ETPTSelSSSIFRSP
  654-  666 (23.61/ 7.53)	SKPTN..SSSIEVSP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     135.54|      41|     629|     958|    1000|       7
---------------------------------------------------------------------------
  958- 1000 (66.83/45.12)	TCkLGTHSPQnLGNQMEIDSGKSP.SSGFVLLDCPQSMKIESNN
 1590- 1631 (68.71/38.12)	TC.LTAESPP.LAHLLHSKGSAIPlSTGFVVSKSVPSMRKDHKN
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP33224 with Med13 domain of Kingdom Viridiplantae
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