<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP33183

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMGELGQQTVPFSTLVSRAAEDSFASLKELVEKSKTGEESDTDKKINLLKYIVKTQQRMLRLNVLAKWCQQVPLIHYSQQLASTLSSHDTCFTQAADSLFFMHEGLQQARAPIYDVPSAIEVFLTGSYQRLPKCIEDMGMQSTLTKDQQKAALKKLDTLVRAKLLEVSLPKEISEVKVSSGTALLRVDGEFKVLVTLGYRGHLSMWRILHLELLVGERSGPVKLEESRRHVLGDDLERRMSAADNPFITLYSILHELCVALVMDTVIRQVQALRQGRWKDAIRFELISDGSMGHGASGSSIQPNQDGEVDSAGLRTPGLKLIYWLDFDKNPGSSDSGSCPFIKIEPGPDLQIKCLHSSFVIDPLTGKEAEFALDQSCIDVEKLLLRAISCNRYTRLLEIQKELGKNIQICRAPSDVVLQSFMDELDADNRKKDNKSEFRDYEGQEVLRVRAYGSSFFTLGINIRNGRFLLQSSHKILAPSVLSDCEEALNQGSTSAAEVFISLRSKSILHLFAAIGRFLGLEVYDHGFASMKVPKNLVNGSTVLLMGFPDCGSSYFLLMELDKDFKPMFKLVETQPDQSEKGQSSSDLNRVIRIKQIDISQMQILEDELNLSILNQGNLLSVMPNADGANHTSEQGLISEFNLDGSMHIAGCPLSSFSSVVDEVFEFEKGPAASSYTLQNVSSSFTTSSASHFGSLQMNLHGVKAGTPSPRWEGGVQMSHLNVAKGSIGNTQYNGSLYSSSNVKGPVQSSSFSSLSSGLARSTAVKKLPASKSDQDLASLRSPHSVEIGTVEEDLVSVGRSSRLLSPPRTASVRAPPPSAKPNGPRSSVTGSLAGSIKVAGSSSLASPPVSHAADTDIVSKHDKHPRKRTVSDMLSLIPSLQDIEAATGLSNKRRKISESAHFQQPLSGGLISAEIVSKAERYSYGNLVAEANKGNAPSSTYISALLHVVRHCSLCIKHARLTSQMELLDIPYVEEVGLRSASSNIWFRLPFARGYTWRHICLRLGRPGSMHWDVKINDQHFRDLWELQKGSNSTPWGSGVRIANTSDIDSHIRFDPEGVVLSYQSVEDDSIKKLVADIQRLANARMFALGMRKLLGVRADEKPEEGTANFDVKAPVGGKGASEASDKLSEQMKRAFRIEAVGLMSLWFSFGSVVLARFVVEWESGKEGCTMHVSPDQLWPHTKFLEDFINGAEVASLLDCIRLTAGPLHALGAATRPARAGTGPGVPGVATAVSTIPKQTGYSSSQGLLPNGSTTNVSQVTSAPTGLNVSQVTSASTGNPVGAASTVPLGNPNLHGAAMLAAAGRGGPGIVPSSLLPIDVSVVLRGPYWIRIIYRKHFAVDMRCFAGDQVWLQPATPPKGGPSVGGSLPCPQFRPFIMEHVAQELNGLDSNITGGQQTVGMANTNPSSGSQLASANGSRVNIPSSAAMSRAVNQVAALNRVGNPMPGSSNLSVVSSGLPIRRSPGASVPAHVRGELNTAIIGLGDDGGYGGGWVPLVALKKVLRGILKYLGVLWLFAQLPDLLKEILGSILKDNEGALLNLDQEQPALRFFVGGYVFAVSVHRVQLLLQVLSVKRFHQQQQQQQQQNSSTAQEELTQSEIGEICDYFSRRVASEPYDASRVASFITLLTLPISVLREFLKLIAWKKGLAQTQGGEIAPSQKPRIELCLENHSGFNVDDGSVNSSASKSNIHYDRPHNSVDFALTVVLDPAHIPHINAAGGAAWLPYCVSVRLRYSFGENPNVSFLGMEGSHGGRACWLRTDEWEKCKQRVARVVEVNPVSAGDLTQGRLRIVADSVQRTLHMCLQGLKDGGTVTASSVGV
Length1820
PositionTail
OrganismCitrus clementina
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> rosids> malvids> Sapindales> Rutaceae> Aurantioideae> Citrus.
Aromaticity0.06
Grand average of hydropathy-0.165
Instability index45.51
Isoelectric point8.12
Molecular weight197169.08
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP33183
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     353.38|     109|     162|    1243|    1357|       1
---------------------------------------------------------------------------
 1243- 1357 (176.90/101.41)	SSSQGLLPNGSTTNVSqvTSAPTGLNVSQVTS.ASTGNPVGAASTVPLGNPnlhGAAMLAAAGRGGPGIVPSSLLPIDVSVVLRGPY...WIRIIYRKHFAVDMRCFAGdQVWLQPATP
 1408- 1520 (176.48/87.43)	SGSQLASANGSRVNIP..SSAAMSRAVNQVAAlNRVGNPMPGSSNLSVVSS...GLPIRRSPGASVPAHVRGELNTAIIGLGDDGGYgggWVPLVALKKVLRGILKYLG.VLWLFAQLP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     210.81|      59|     158|     973|    1032|       2
---------------------------------------------------------------------------
  973- 1032 (110.11/73.00)	VEEVGLRSASSNIWFRLPF.....AR.GYT..WRHIC.LRLG.RP..G.SMHWDVKiNDQ...HFRDLWELQKGSN
 1066- 1113 (37.58/18.26)	VEDDSIKKLVADIQ.RLAN.....AR.MFAlgMRKLLgVRADeKPeeG.TANFDVK....................
 1138- 1193 (63.12/36.24)	IEAVGLMS....LWF..SFgsvvlARfVVE..W......ESG.KE..GcTMHVS...PDQlwpHTKFLEDFINGAE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.17|      14|      72|     668|     689|       3
---------------------------------------------------------------------------
  676-  689 (22.27/ 6.37)	TLQNVSSSFTTSSA
  750-  763 (21.90/11.64)	SFSSLSSGLARSTA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      86.10|      26|      36|     504|     530|       4
---------------------------------------------------------------------------
  504-  530 (41.64/35.50)	SKSILHLFAAIGR..FLGLEVyDHGFASM
  540-  567 (44.46/31.73)	STVLLMGFPDCGSsyFLLMEL.DKDFKPM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     242.35|      59|     259|     617|     675|       5
---------------------------------------------------------------------------
  301-  339 (25.87/10.04)	QPNQDG..EVDSAglrTPGlkL.IYWLDF.DknpGSSDSGSCP...........................................
  622-  695 (92.71/59.35)	MPNADG..ANHTS...EQG..L.ISEFNL.D...GSMHIAGCPLSSFSSVVDEVFEFEKGPAASSYtlqnvsssfttssasHFGSL
  696-  749 (52.50/29.69)	QMNLHGvkAGTPSprwEGG..VqMSHLNVaK...GSIGNTQYNGSLYSS..SNV....KGPVQSS.....................
  823-  876 (71.27/43.53)	.....G..PRSSV...TGS..L.AGSIKV.A...GSSSLASPPV.SHAADTDIVSKHDKHPRKRTV..............sDMLSL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.05|      12|      36|     130|     141|       6
---------------------------------------------------------------------------
  130-  141 (23.49/16.07)	LPKCIEDMGMQS
  168-  179 (19.56/12.06)	LPKEISEVKVSS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     248.08|      84|    1170|     386|     477|       9
---------------------------------------------------------------------------
  386-  477 (119.36/112.20)	AISCNRYTRLLEI.......QKELGKNIQICRAPSDVVLQSFMDELdADNRKKDNKSEfrDYEGQevlRVRAYgSSFFTLGINIRNgRFL.LQSSHKILA
 1558- 1649 (128.72/89.90)	AVSVHRVQLLLQVlsvkrfhQQQQQQQQQNSSTAQEELTQSEIGEI.CDYFSRRVASE..PYDAS...RVASF.ITLLTLPISVLR.EFLkLIAWKKGLA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      67.34|      20|    1354|     342|     361|      11
---------------------------------------------------------------------------
  342-  361 (38.10/25.82)	KIEPGPDLQIK.CL..HSSFVID
 1655- 1677 (29.24/17.89)	EIAPSQKPRIElCLenHSGFNVD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.22|      13|    1354|     288|     300|      13
---------------------------------------------------------------------------
  288-  300 (25.24/14.87)	DGSMGHGASGSSI
 1678- 1690 (22.98/12.76)	DGSVNSSASKSNI
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP33183 with Med14 domain of Kingdom Viridiplantae
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