<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP33120

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMAELGQQTVEFSALVGRAAEESFLSLKELVEKNKSTELSDTDKKVSLLKYVVKTQQRMLRLNALAKWCKQVPLINYCQDLGSTLSAHDICFTQAADSLFFMHEGLQQARAPVYDVPSAVEVLLTGSYQRLPKCLDDVGMQSSLDEHQQKPALRKLEVLVRSKLLEITLPKEITEVKISKGTVTLSVDGEFKVLVTLGYRGHLSMWRILHLDLLVGERSGPIKLEMTRRHILGDDLERRMSVAENPFTILYAVLHEFCVAIVMDTVIRQVRALLQGRWKDAIRFDLISDTGTTPVNQEGEADSVSLRTPGVKLIYWSDSDKNSGPFIKIEPGSDLQIKCLHSTFVVDPLTGKEAEFSLDQSCIDVEKLLLKAICCNRYTRLLEIQKELLRNARICRAPSDVILQAFLDEPGIEGGNMVDSKEHAGPEVLRVRAYGSSFFTLGINIRTGRFLLQSSKSILIPSILDEFEDALNQGSISAVDAFISLRSKSILHFFATIGKFLGLEVYEHGFGVNKVPKNLSDGSSILTLGFPDCESSHLLLMELEKDFTPLFKLVETQMDGSGKPQSFNDLSNVLRVKKIDIGQIRILEDDLNLITSDVVRFVSSFSDAESLNQASGHRHPGLIDESLAEMNGSQLSFSSIVDEVFGLQKGTSALVSSDGHDSIPKNLPAVNGLGEVPLLTSYQPDSLYNLQGPLQSSSLNLLSAPPRKSSVMKKIAISNSNPELSMILSPSLSAGNGVSEPGSRMVTKSSLSPPPVSQTADLATTSDGPLLRKDQKSRKRSASDLLRLIPSLQGVEGVANPNKRCKTSSELVQSELVKSWSPASQTLSASVATSTKTIGCSYGNLIAEANKGNAPSSVFVYALLHVVRHSSLSIKHAKLTSQMEALDIQYVEEMGLRDAFSDIWFRLPFAQNDSWQHICLQLGRPGSMCWDVKINDQHFRDLWELQKGSKNTPWGSGVHIANSSDVDSHIRYDPEGVVLSYQSVEADSIKKLVADIQRLSNARMFSLGMRKLLGIKPDEKQEDCSANPTIKGPAGGKGSGEPVDRWRAFKIEAVGLTSLWFSFGSGILARFVVEWESGKDGCTMHVSPDQHWPHTKFLEDFINGAEVESLLDCIRLTAGPLTALAAATRPARASTATGVPVVPATATSRQSNQIQQTQGIISPSTLAAPNAVGQSASGTSGTTIASPAPSPLGGSFHGVAMLAAAGRSGPGIVPSSLLPIDVSVVLRGPYWIRIIYRKRFAVDMRCFAGDQVWLQPATPPKGGASIGGSLPCPQFRPFIMEHVAQELNGLEPNLTSQGATNPNSVNPTGSGGSRVNFSPSSAMSRAAMNRVGSVASGSLVGGSGLSVRRPPGTAVPAHVRGELNTAIIGLGDDGGYGGGWVPLVALKKVLRGILKYLGVLWLFAQLPDLLREILGSILKENEGALLNLDQEQPALRFFVGGYVFAVSVHRVQLLLQVLSVRRFHHQQQQQQQNGSSAAALEDLTQSEIGEICDYFSRRVASEPYDASRVASFITLLTLPISVLREFLKLIAWKKGLSQSQQAGEIAPAQRPRIELCLENHSGTDVDHSCAAKSNIHYDRPNNTVDFALTVVLDPAHIPHINAAGGAAWLPYCVSVRLRYTFGENPSVTFLGMEGSHGGRACWQRVDDWEKCKQRVSRTVEVNGSAAGDLTQGKLKLVADSVQRTLHLCLQGLREGNNNTLQKEFTI
Length1705
PositionTail
OrganismEutrema salsugineum (Saltwater cress) (Sisymbrium salsugineum)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> rosids> malvids> Brassicales> Brassicaceae> Eutremeae> Eutrema.
Aromaticity0.06
Grand average of hydropathy-0.125
Instability index43.78
Isoelectric point6.88
Molecular weight185527.64
Publications
PubMed=23518688

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP33120
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     322.04|     112|     260|     120|     248|       1
---------------------------------------------------------------------------
  120-  248 (157.10/182.64)	EVLLTGSYQRLPkclDDVGMQSSLDEhqqkPALRKLEvLVRSKllEITLPkEITEVK.ISKGTVTLSVD...GEF......KVLV..TLG.YRGHLSMWRILHLDLLVGERSGPI.KLEMTRRHILGddLErrmsVAENPFTI
  386-  511 (164.94/132.00)	ELLRNARICRAP...SDVILQAFLDE....PGIEGGN.MVDSK..EHAGP.EVLRVRaYGSSFFTLGINirtGRFllqsskSILIpsILDeFEDALNQGSISAVDAFISLRSKSIlHFFATIGKFLG..LE....VYEHGFGV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      70.65|      19|     259|    1360|    1379|       2
---------------------------------------------------------------------------
 1360- 1379 (34.56/24.89)	GElNTAIIGLGDDGGYGG..GW
 1621- 1641 (36.08/21.29)	GE.NPSVTFLGMEGSHGGraCW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     218.89|      52|     115|    1139|    1194|       3
---------------------------------------------------------------------------
  726-  754 (37.53/14.79)	......................ILSP......S.L...SAGNGVSE..PGS....RMVTKSSLSPPP
 1139- 1190 (90.73/65.65)	PVVP..ATATSRQSNQIQQTQGIISP......STL...AAPNAVGQSASGT....SGTTIASPAPSP
 1255- 1302 (47.90/25.80)	PATPpkGGASIGGSLPCPQFRPFIMEhvaqelNGL....EPNLTSQGATNP....N...........
 1304- 1349 (42.73/21.84)	.VNP..TGSGGSRVN........FSP......SSAmsrAAMNRVGSVASGSlvggSGLSVRRP....
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      80.69|      23|     589|     955|     977|       6
---------------------------------------------------------------------------
  955-  977 (41.66/28.70)	SGVHIANSSDVDSHIRYD.PEGVV
 1560- 1583 (39.03/26.40)	SGTDVDHSCAAKSNIHYDrPNNTV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      97.85|      29|     589|     603|     632|       7
---------------------------------------------------------------------------
  603-  632 (46.94/37.26)	SFSDAESLnQASGHRHPGLIDESLAEMNGS
 1194- 1222 (50.91/35.20)	SFHGVAML.AAAGRSGPGIVPSSLLPIDVS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     136.18|      44|     589|      69|     119|       9
---------------------------------------------------------------------------
   69-  119 (66.60/57.52)	KQVPLINycqDLGSTlsahDICFTQAADSLFFMHEGLQQARAPVYDVP...SAV
  664-  710 (69.58/41.49)	KNLPAVN...GLGEV....PLLTSYQPDSLYNLQGPLQSSSLNLLSAPprkSSV
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP33120 with Med14 domain of Kingdom Viridiplantae
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