<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP33111

Description Mediator of RNA polymerase II transcription subunit 17
SequenceMDSDMEISLDRLPIKRLESIEENGAERFPSDVNYDDKRVSLIRRIDFAWALEEEDELKKKKQKKSSKESSEQWQWKGMVENLQLAHQELSVIIDLINTVEANDAVTVAGMTKPKPMPNELLSDLAVSTATKLQSYRHLGKYFKQSAKALEQKVNREARFYGALIRLQRNWKVKRQRVLASNASNEGFTIDLSDSSLYDPTSGFRPSTLSTIRVEHDSAGMLAINLPQDSWYSLRFGFVGLNSIDNPNESAEHIDSTTGQDTTSEKLSVSDEESVKETHSLLREVHKSIFAEQLFDMLNREAFSEGVGFSISGIRENFLEMSIGQGASLFVSLYPSGKNASIKKSESAIVPMESSGGIELVEGDSRVKKLGFPSRASYDIYLQQIFHEHVFGKAKDQTKSKSSQASNQTAKDNNSGLLDHFCLSLAHRIFSTRVVVQLESVVCKVPYLHLISHPTWNSRTSSWTVCMTVPPSIIPQGSSETQSLDGKRNLKTQFRTKVVVKDDCISVEAECTPNVVGLLKSSSCNLFSMNKYECDLADLPVIILQQVTSQIVCWLLEEARTVGTKASRDFLSLSLEIVEGERVSLVAQVNPEDAKGCISWWLVMENGCTEERKGVSESRKLLGHLSLDVLYSVLMDLINLCGSGRNPLDRL
Length650
PositionHead
OrganismEutrema salsugineum (Saltwater cress) (Sisymbrium salsugineum)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> rosids> malvids> Brassicales> Brassicaceae> Eutremeae> Eutrema.
Aromaticity0.07
Grand average of hydropathy-0.344
Instability index43.87
Isoelectric point5.77
Molecular weight72655.52
Publications
PubMed=23518688

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP33111
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     276.84|      93|     134|     195|     294|       1
---------------------------------------------------------------------------
  195-  294 (134.67/112.85)	SLYDPT..SGFRPSTlSTIrVEHDSAGmlAINL.PQDSWYSlRFGFVGLNSIDNPNES..AEHIdSTTGQDTTSEKLSVSDEESVKETHSLLREvHKSI.FAEQLF
  331-  429 (142.17/91.02)	SLYPSGknASIKKSE.SAI.VPMESSG..GIELvEGDSRVK.KLGFPSRASYDIYLQQifHEHV.FGKAKDQTKSKSSQASNQTAKDNNSGLLD.HFCLsLAHRIF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     183.20|      56|     405|      69|     125|       2
---------------------------------------------------------------------------
   69-  125 (92.66/70.26)	SSEQWQWKGMvENLQLAHQELSVIIDLINTVEANDAVTVAGMTKPKPMP....NELLSDLA
  477-  536 (90.53/63.92)	SSETQSLDGK.RNLKTQFRTKVVVKDDCISVEAECTPNVVGLLKSSSCNlfsmNKYECDLA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      74.22|      25|      49|     551|     576|       3
---------------------------------------------------------------------------
  551-  576 (40.07/25.24)	VCWLL......EEARTvGTKASRDFLS.LSLEI
  597-  628 (34.15/17.14)	ISWWLvmengcTEERK.GVSESRKLLGhLSLDV
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP33111 with Med17 domain of Kingdom Viridiplantae
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