<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP33063

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMWTNVFRIGGLHNVSWFQFLPSETELNPGSDRSSRAEQNDVASYLVLSSHLRLQKEGFLCTWTNSFVGPWDPSQGLYNPDEKIKLWLFLPGRHSSITDKAQAAVSKLRVVASGIWVAPGDSEEISVAFSQSLRNCIERALTGLSYMRFGDVFSKFSPQSEDYLRRGQPTVEFIFAATEEAVFVHVIVSAKNVRTLSCSDAERLLRSSLKNSSYRLPVIVSPHGMRGSLTGFCPNDLVKQVYFSSGNLRTSSGYIGLASHVGRGPRMINGNHCYVEVTLGCCQNINDNTSQTNSTFPHNQCPEPSVGSKDHRKGQPDVLSVCEKKFIYPAEAVLVPILQSAFAKFSLKRFWLQNWIGPSLAGSSLFMHWAGDFDFLGASGNKSDGYYEKNGYNSSGSSRNSSISSTSSASSGSGWRMTSRTGDLDADADSLTCRQSGLTCNDDRPKMGSKRPRTGMAESFGQVGIANDKIGWDWDDDDDGDDDRGVGMDIQALLSEFGDFGDFFENDALPFGEPPGTAESHALMFPPDSADVGSSPVDMMDVSDQIVLPVGFSSFESFNPVPPIIDESLIKNQEVFNSSVTSVPINQMSSSSTGEFDHLMKAEAMMTFAPEYGAVEAPMSEISSTFFKSPYLPKSRKVESSNSRTSNYVYGPTPPATDSDGVADKILLGSKACIGNNDSRTLFQSKYYTQVESRKDQYDKLPTVVSDNKSTKEGVSQLKYSNYSAGSAVKTVQGKKTDGISGVVSTLLSSKTLLATDVGSVMFQAFMCRMRHIVISSKHHSPVSLTRLTGNFFLNQLPNEPSTLTDNISARNEIYKKEIPTRIAGDFDGGMLDSHMSAPVGVWRTVSVPKAAKPASSPNIEAGSSLPHSSFSEDSLLSYGQRQPLQELLDGIALLVQQATSFVDLALDSDCGDGPYGWLALEELWRRELSCGPSAGHAGCGGTLASCHSLDIAGVKLVDPLSAEVFPSSVITLLQSDIKTALKSAFGQSDGPLSVTEWCKGRNQSVDGGSISEGSTAESTLSEASNVVDGAKGEETAHSQDIYSSELLRPTLFVLPSPSILVGYQDDWLKISTNSLPHWEKAPFEPYALPKNINYTVVCPDIDPLTCAAADFFQQLGTVYETCRLGTHLPHILGNQMETDAGRLSSSGFVLLNCPQSMKIESNNTSLLGSLSDYFLSLSNGWNVSSYLKSLSKALKGLKLGSCLYTNQKEGSASPCMVVYIVCPFPDPSAVLRTIVESSIALGSGIQPDRDRRSMLNSQVARAFGSSAAVDEASISHIPVLSGFSVPKLILQVVSVDSIFRITSPSFNELVILKDTAFSVYNKARRISRGMPNDGFLSSSLSSRSSSALSSMSSISGIWKDCVGSRMTGSTHPRDGETGGWESSWPIARSGGLSCDPNRNGDFYLNDEIFYLFEPLFILSEPGSVERGVSPTFGSLGSESSKPIPEDGGRGSGPGVNSMEGIPSGSSSQGDTSQLEGKAIPSLHCCYGWTEDWRWLVSIWTDARGELLDTHIFPFGGISSRQDTKGLQCLFVQVLQQGCQILQACSSPDNGSFKPRDFVITRIGSFFELEYLEWQKAIYSAGGPEIKKWPIQLRRSAPSGVATNNNGSSLQQQDLSLIQERASSTSTLYSSHAKPSTFVKGTMGQSAGRKQIMGGQTISGTPRGLFQWVHSISFASISLDHSLHFVLPTELVSPGGGQSSTGMSSINYIEGFTPVKSLGSTAFSYMMIPSPNMRFLHPSPLQLPTCLTAESPPLAHLLHSKGCAIPLSTGFVVSKAVPSMRKDSRINMKEEWPSVLSVSLIDYYGGYDHAHDKIRQGIMKQGGGIKETRDFEVESHLILESVAAELHALSWMTVSPAYLDRRTALPFHCDMVLRLRRLLHFADKEVSRLPDKSGV
Length1894
PositionKinase
OrganismEutrema salsugineum (Saltwater cress) (Sisymbrium salsugineum)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> rosids> malvids> Brassicales> Brassicaceae> Eutremeae> Eutrema.
Aromaticity0.09
Grand average of hydropathy-0.240
Instability index49.76
Isoelectric point5.73
Molecular weight205432.67
Publications
PubMed=23518688

Function

Annotated function Component of the Mediator complex, a coactivator involved in regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP33063
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     416.89|     171|     197|    1074|    1270|       1
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 1074- 1137 (29.46/24.21)	.......................................................................................................................................................SLPHwekAP.FEPYALPKNInYTVVcpDIDPLTCAAADFFQQL....GT...VYETC.RLGTHLPhilgNQ..ME
 1138- 1337 (226.79/132.48)	TDAGRLSSSGFVLLNCPQSMKIESNNTSLLGSLSDYfLSLSNGWNvSSYlkSLSKAlKGLklgSC.......LYTNqkEGsaspcmVVYIVCP...FPDPSAVLRTIVESSIALGS....GIQPDRDRRS..MLNSQVARAFGSSAAVDeaSISH...IPvLSGFSVPKLI.LQVV..SVDSIFRITSPSFNELvilkDTafsVYNKArRISRGMP....NDgfLS
 1338- 1470 (160.64/68.06)	SSLSSRSSSALSSMSSISGIWKDCVGSRMTGSTHPR.DGETGGWE.SSW..PIARS.GGL...SCdpnrngdFYLN..DE......IFYLFEPlfiLSEPGSVERGVSPTFGSLGSesskPIPEDGGRGSgpGVNSMEGIPSGSSSQGD.............................................................................
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     963.28|     312|     498|     193|     568|       2
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  193-  542 (510.55/309.44)	RTLSCSDAERLLRSSlKNSSYRLPVIVSPHgmRGSLTGFcpnDLVKQVYFSSGN.LRT.....SSGYIG...........LASHVgrGPRMINGNHCYV.EVTLGCCQNINDNTSQTNSTFPHNQCP.EPS.....VGSKD..HRKGQPD.........................vlsvcekkfiypaeavlvpilqSAFAKFSLKRFWLQNWIGPSLAGSSLFMHWAGDFDFLGASGNKSDGYYeknGYNSSGSSRNSSISSTSSAS.SGSGWRMTSrTGDLDADADSLTCRQSGLTCNDDRPKMGSKRPRTGMAESFGQvgiANDKIG.WDWDDDDDGDDDRGV...GMDIQALLSEFGDFGDFFENDALPFGEPPGTAE...SHALMFPPDSADVGSSPvDMMDVS
  679- 1071 (452.73/195.97)	RTLFQSKYYTQVESR.KDQYDKLPTVVSDN..KSTKEGV...SQLKYSNYSAGSaVKTvqgkkTDGISGvvstllssktlLATDV..GSVMFQAFMCRMrHIVISSKHHSPVSLTRLTGNFFLNQLPnEPStltdnISARNeiYKKEIPTriagdfdggmldshmsapvgvwrtvsvpkaakpasspnieagsslphSSFSEDSLLSYGQRQPLQELLDGIALLVQQATSFVDLALDSDCGDGPY...GWLALEELWRRELSCGPSAGhAGCGGTLAS.CHSLDIAGVKLVDPLSAEVFPSSVITLLQSDIKTALKSAFGQ...SDGPLSvTEWCKGRNQSVDGGSiseGSTAESTLSEASNVVDGAKGEETAHSQDIYSSEllrPTLFVLPSPSILVGYQD.DWLKIS
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.59|      14|     150|     171|     186|       5
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  171-  186 (20.15/18.84)	EFIFAAteEAVFVHVI
  324-  337 (25.44/16.25)	KFIYPA..EAVLVPIL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      58.36|      16|    1057|     638|     653|       7
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  638-  653 (31.46/15.54)	ESSNSRTS.NYVYGPTP
 1697- 1713 (26.90/12.28)	QSSTGMSSiNYIEGFTP
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP33063 with Med13 domain of Kingdom Viridiplantae
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