<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP33046

Description Mediator of RNA polymerase II transcription subunit 15
SequenceMADGQDWRSQSFRNQLVAQIDDAIRQAGPHISKTSQEMETHVHNKAKSKEEYLALVARLILHIKDSNKDKQQPRQQQQMMMGQPAGRQMGQMNPQMAGRPIQDPINALTNLTRPMQQQQQGMPHMMQHRPMQMSAAQIRFQQQQMQQQKPQLQRQDAFIVTSPQTNPVQSQPLPASAANLPFQSQPQTMQRQVPQMPQHMSQVPSPAQICSPAVFTAPSPQSMVAPSPVNRGAVGVLSPGAALNTPGNPGSVGAAPSPSNQRINDEQIYMEKLQQLSKYVGPLSKMVDRLEKDESQKLEHLKMKNLLDILTDPTKRVTYATLEKCEIVLEKMGKHVTQSQPQTSSSVFESLYESIASNIQSPSINHSLQRTFGPAISAFFGPAIKAPVEPCKKRRKLEEDKKEGLSNVLQGEIARLHSRFHISVDSLQHSSNTSVHLICKLDDKNLPSVPPLIVKIPKTYPQGTPECDTESEGYNSTPFFQNIQKHLEQSLLNMSNKYSLSSLLYSWEMSVRRSCED
Length517
PositionTail
OrganismLottia gigantea (Giant owl limpet)
KingdomMetazoa
LineageEukaryota> Metazoa> Spiralia> Lophotrochozoa> Mollusca> Gastropoda> Patellogastropoda> Lottioidea> Lottiidae> Lottia.
Aromaticity0.04
Grand average of hydropathy-0.686
Instability index77.29
Isoelectric point9.19
Molecular weight57899.36
Publications
PubMed=23254933

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP33046
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     156.76|      24|      38|      73|      96|       1
---------------------------------------------------------------------------
   73-   96 (52.46/23.33)	PR.QQQQMMMGQPA.GRQMGQM..NP.QM
  114-  133 (37.12/14.30)	PM.QQQQ..QGMP....HMMQH..RPmQM
  138-  165 (29.04/ 9.55)	IRfQQQQMQQQKPQlQRQDAFIvtSP.QT
  181-  200 (38.14/14.90)	PF.QSQPQTM.Q....RQVPQM..PQ.HM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.43|      16|      16|     344|     359|       4
---------------------------------------------------------------------------
  344-  359 (25.68/14.68)	SSSVFESLYESIASNI
  361-  376 (28.75/17.20)	SPSINHSLQRTFGPAI
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP33046 with Med15 domain of Kingdom Metazoa
Unable to open file!