<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP33017

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMSLADTDDVLAIELDVARVAYVSYTSTSTAAAQTSRHKLLQSNSGGLDDCYIPTVQVSAAGAVLWIFRILQASAEVDDILKFLGNLSNEGLQIKEEPQLFSPAHLYPCSEECSYQSKPCSHCINPPSTSSAPPRPPTSSASRLPRRSLRAVWSAFLQAARGSIIADIATRAENSASGRAVNRIKDGFLLGHAPSRLSPRSEWTAGWEGRIKGKPLVYTHIHLHLTGEKLIIHPTLHPTPFIPLAAKSLQQGAPITLLPYGTPAYYLSTYSGPTSTLAKQFREALQGCGVSLKFTAYVIIWIPVENAHGEEKGLTAIYPTELCVSFIPTPGTVPPLVHRSTTSSPISTAPPPFPTTGPWTPYGRSLLPTIPTLPPPLQPSPTVLHVVPPGFSAPSPNPAIVLSGSSYIPTPPATTLPVPVSATVPTSPYSTGHPVSSSFPPLFPPPYAISITPNERLSLALSRSYSLTFKARRQRQHKATFHSVQTSLSKSPDTILSLTHATEASGFVDMTAKEREKERERLRAGVSGRQTQDNQSSSQGQQSSTSQTRTAAPTQTQATEPVSHPPTIQTPYPNIAQPGPSTAHPFQPQQYPQSTFYPSPPDPHGSVPPIPLKVEVSDTIEQPITGPSQPEPPPQKIEPKDEESMDVDDDDLFGVSPPPSAENPDPIVKDSPKPEPPAVTETVDVKPDAERDDWDAMNMDWGAMDNMSMDLDMDMDMGMGMGMDMSMGMDAFGFGSSSSSSESKTVSSSLPVRPPLPPPPQTQPSVNAAVVTAPVAVRSVPTTVTSVSMTKPSSSLSFEDDITDDDYNWFDTHDTGGSERNDNTSGFMGISTSGGTNGSLDAGATLFSAISTSHPSAHSIQPFSSRSMHPPPVPPHAHHGFGYAPSPASTSASPWTSHAHIGHGETPDTMGTPSVAISMSASGDAFPLSPPEEGTPNIIGMLAGTPQTPNTAVINVTGGRWGSGWGVQLESPFSSPERKASTSTRATANSRRLSSFDPIPFAASHRLADGKYTCGKFTLPSPPLEGEEADSYFSAVGVKGNADTNGSSGLSPALKGLRINYDKKTDPRIAVVAQLRLRGVKRKSTASPALPGTRYMSPRWVKEWEEGLKATLPISPASMNDSDDDNSASDDEDNDSDDDLFDLGTSTSSPTAPEYSRPTTPLPAYVPPGPTLLSTHFHHTHLLPLSTPLRSPGTRHEETHLNNLSGNGSLNAAAASVPTPVSPAAMLGAAAEQSKSLEATAEMVAREVVENSLWGEIWTMNHCFGKHSDLSGTELCAVSDMSIDDGLNASMGPELAKQQVWTIDIHVVKELLSGVSGLKGPLTLGNVFDPVIPSVSVPHSPAPSTSHTVHPLQPPHLAVGKGDGVLEVLPTALRFWEKLGLGPKYGQKNATAFVLFDDDDEWCQQRVEVWLSNFAGTYQRKGLGNIVPGTSTFCSRDGLVPLRFDSSFRKNLASFATSLPASQTNFIFFVIIPSSAMILSSPLLRQVLSTVKKAVKNYSEAQIVFQLLPEEILLGHMDVSSVEDLGTEQLCYSVYDRILRPVDRTMAREFFEHGVRVRNYFQEPFTTLGRTLGQQKVTYVNSAHASLDVMDRHTLLHVGYQVSYCGKWILAAIIDQRGEAHDLGVWLARTHDSDADDAVSDEMHTVSKVWDFALRFAERADVEWRIVFAKLGLITAAELDAWTSLLASRLQVVSSRTPIHVSLLSIEPSAPWAIFPKRLKPSTPLSSQSSTSIAKAPALSRSSSMPSKASLKNGAPYFIDGSQTTYALFHNCSLTVSRAPTMESVGITSNIITDKPHGSSEGVRELPLLPLCSCTLVRMPASTSSPPTSIITPNMVDLHLMHAAGSRGSTYPPTSRNHSANDSEASTSHPSTATLHRGLMNDILYSYYALSVLSASRSKLSGVNPLLPFNLGAVEAMRNALSFGRIQVDGND
Length1931
PositionKinase
OrganismMoniliophthora roreri (strain MCA 2997) (Cocoa frosty pod rot fungus) (Crinipellis roreri)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Basidiomycota> Agaricomycotina> Agaricomycetes> Agaricomycetidae> Agaricales> Marasmiaceae> Moniliophthora.
Aromaticity0.07
Grand average of hydropathy-0.288
Instability index52.37
Isoelectric point5.84
Molecular weight207096.36
Publications
PubMed=24571091

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
ECO:0000256	RuleBase:RU364134
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP33017
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.85|      15|      17|     696|     711|       1
---------------------------------------------------------------------------
  696-  711 (28.77/24.18)	MNMDWG.AMDnMSMDLD
  714-  729 (29.07/18.68)	MDMGMGmGMD.MSMGMD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     899.73|     333|     487|     387|     873|       2
---------------------------------------------------------------------------
  330-  513 (133.61/49.72)	.............................................................................................................................................................................................................................................................................................................................................GTVPPLVHRSTTSSPISTAPPPFPTTGPWTpyGRSLLPtiPTLPpplqpsptvlhvvP.PGFSAPSPNPAIVLSGSSYIPTPPATTLPVPVSATVPTSPystghpvSSSFPPLFPPPYAiSiTPNERLSL.ALSRSYSLtfkarrqrqhKATFHSVQTSLskSPDTILS....LTHATEASgFVDMTAKE
  514-  661 (117.41/224.52)	REKERERL......RAGvSGRQTQ.DNQSSSQGQQSSTSQTRTAAPTQTQATEPVshpptiqtpyPNIAqpgpstAHPFQPQQYPQSTF.YPSPPDPHGSVPPIPLKVEVSDTIEQPitGPSQPEPPPQKIEPKDEESMD.....VDDDDLFGVSPPPSAE..........................................................................................................................................................................................................................................................................................................................................................................
  753-  944 (199.85/146.30)	.................................................................................................................................................................npdpivkdspkpeppavtetvdvkpdaerddwdamnmdwgamdnmsmdldmdmdmgmgmgmdmsmgmdafgfgssssssesktvssslpvrPPLPPPPQtqpsvnaavvTAPvavRSVPTTVTSVSMTKPSSSLSFEDdiTDDDYNWFDTHDtggserNDNTSGFMGISTSgGTNGSLDAGATLFSAISTSHPSAHSIQPFS..SRSMHP..PPVP...phahhgfgyaPsPASTSASPWTSHAHIGHG..ETPD..TMGTP.SVAISMSA.......SGDAFPLSPPEEG...TPN.........................................................IIGMLAGT
  945- 1246 (448.86/ -nan)	PQTPNTAVinvtggRWG.SGWGVQlESPFSSPERKASTSTRATANSRRLSSFDPI..........PFAA......SHRLADGKYTCGKFtLPSPPLEGEEADSYFSAVGVKGNADTN..GSSGLSPALKGLRINYDKKTDpriavVAQLRLRGVKRKSTAS...........................................................................................PALPGTRY..........MSP...RWVKEWEEGLKATLPISPASMND..SDDDNSASDDED......NDSDDDLFDLGTS..................TSSPTA....PEY..SRPTT.............................PLPAYVPPGPTLLSTHFHHTHLLPLSTPL.RSP.....................G.TRHEETHLnNLSGNGSL..........NAAAASVPTPV..SPAAMLGaaaeQSKSLEAT..AEMVARE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      72.60|      22|     943|     299|     324|       3
---------------------------------------------------------------------------
  299-  324 (32.10/34.87)	IWiPVENAHGEEKGLTAiypTELC.VS
 1256- 1278 (40.50/26.48)	IW.TMNHCFGKHSDLSG...TELCaVS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     142.64|      43|    1599|      63|     160|       4
---------------------------------------------------------------------------
  117-  160 (73.80/93.62)	KPcSHCINPPSTSSAPPRPPTSSASRLPRR.SLRAVWSAFLQAAR
 1719- 1762 (68.84/15.32)	KP.STPLSSQSSTSIAKAPALSRSSSMPSKaSLKNGAPYFIDGSQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.53|      15|     586|    1311|    1326|       5
---------------------------------------------------------------------------
 1311- 1326 (22.99/15.14)	LSGVSGLKgPLTLGNV
 1899- 1913 (28.53/14.31)	LSGVNPLL.PFNLGAV
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP33017 with Med13 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) ARRQRQHKATFHSVQTSLSKSPDTILSLTHATEASGFVDMTAKEREKERERLRAGVSGRQTQDNQSSSQGQQSSTSQTRTAAPTQTQATEPVSHPPTIQTPYPNIAQPGPSTAHPFQPQQYPQSTFYPSPPDPHGSVPPIPLKVEVSDTIEQPITGPSQPEPPPQKIEPKDEESMDVDDDDLFGVSPPPSAENPDPIVKDSPKPEPPAVTETVDVKPDAERDDWDAMNMDWGAMDNMSMDLDMDMDMGMGMGMDMSMGMDAFGFGSSSSSSESKTVSSSLPVRPPLPPPPQTQPSVNAAVVTAPV
2) DDYNWFDTHDTGGSERNDNTSGFMGISTSGGTNGSLDAGATLFSAISTSHPSAHSIQPFSSRSMHPPPVPPHAHHGFGYAPSPASTSASPWTSHAHIGHGETPDTMGTPSVAISMSASGDAFPLSPPEEGTPNIIGMLAGTPQTPNTAVINVT
3) LPLSTPLRSPGTRHEETHLNNLSGNGSLNAAAASVPTPVSPAAMLGAAAEQ
4) TLPISPASMNDSDDDNSASDDEDNDSDDDLFDLGTSTSSPTAPEYSRPTTPLPAYVPPGPT
5) WGVQLESPFSSPERKASTSTRATANSRRLSS
470
804
1182
1110
964
774
956
1232
1170
994










Molecular Recognition Features






MoRF SequenceStartStop




NANANA