<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP33014

Description Rna polymerase ii mediator complex component
SequenceMSGQTLPAYESHPPTWLPRAHAEADLGYTGFYPPRPGQDEDVLSASNVKNGYVLGFAVTAESYSSQVSISENLRSHETVLKLEDLMNEVFSRKAKQAPFVPPHTFRVPSRVTLNDTKRQAWFDDLANPNVPLSKLGKSVPHGAKGADLLDLLHLKNVSVPRAVWFLRVFGANETAGLRNKPNYNPTQYSTEWTNVVTSHLRKQLLDIALPSPVRAGVNIKQTFKGVLADPENRDKWVSRFSYCLRLLRSFYAEGLVDKGAFFVWLVNQMGSCNLAQAGFVTRIVDEYFDGMMSCRALTRPFLEAYLSKLAEIRTTSAKEYLNETDALIMSHVQRLSLTIPDTFVSPKLWSGYADLIADILVTEITDNAQDEMTENGTHYLSQHMVFNLADIKKRNETMLFRNFPDVSSVRLGSAVSDVEMLNSITNDTDVATLPFFPVASEDWSGMPEKLTTLLTWSVTPLQFGDHRPFVTVTLIRHWRLKAGERANRRDVMPPDELLQDRLFEWLDSAEVSKDTQNIRTIALLYGELVKHHLFSYTGYLQRLIARGESGLSFAEPGTPSRHRSFLRWIPLYNIPSSVINQRKVTLYGLSRVYPEESIIQAIKDEIRTILPELFGGQPNTSLPTPSNISTDYNNLLSACRSDQVRIFKWLLPPLQQTIVQQENEVSHTTLLKCYCVAVELMTRTSCFDTVLELTTYLLEHSSTADLLIPVIDTFRRHATVWAAMDVKRDIIVALSSAHHVWKLRGIQSRPLLALLMEFDAGRYLTDALREEIANDIAVVAMALQPHTDHPNLVPDVLPEILMLVDNAEADSPSMLANGLWIKYRMSFDWAWKVWDNTIASLRQIPVMTPDTRTRRTLALRYGTFLWHVGQHLPAGLDSQVLRWFLGPGRNEMAALSADAWDVVTVVLLYLSVHGALQTTTILEGLVYPAWQQGAHLPNNQQAQAMAMNLRAANNICQQLLLNENCNEDFMPPTSLIDVQALYTRRQDVYKEPHFPLLIANIPALVSLENNANIPEDLRQEAKAIRQRLCEEDPFRQGVYRNLNIVREAFEKSLQSAEGMSEELSKQTVAALRMVLGEGTEDLELSRWPDNASLLSPWKISATAIQLQFVLRQMGRSNAQRARAANVAALDKLTTMIFHNALSPEEANFVAQMTKGVGSEISGKFINNGLRRVTDVISRMTFTLPVLKDSLVRAEELLRVLIYVAEPLRDDPAGLPAVGSDIQDSFLPLLLSKWEELSRLIQADALEQETRVSFSEAVILLARFLQFYLAFRGIWTDKARETSTKLAQILFNLLVSHATGVNADYVAYPLLLDTLYYLLDEIPNDSKAGVFDPFRAYPDMPVSALPSDLPHEYLLQLRSLLPELPTVSSIANLNIAHRDPAGQLVIGGNVVNRPWEWIENLGDAPGSEPKYQESSQRFLKGKEPVKNAGSLSLLTFGARTTGDTIMAHIPDSDARLQSSLRTFEDGLSYEPVFSRDWRESRLDLSDDLMKNENGSRTKGDLSYESKSSPMALQSRGDQRITPRGSPVSTSSHSRGSVASMRQSPGLAAPNRISSSSAAPEIIDVDSFSMSNKRKGTDDSDDDIIIVEGPNTPRNKKPKSKLPVKKTGKRR
Length1609
PositionKinase
OrganismMoniliophthora roreri (strain MCA 2997) (Cocoa frosty pod rot fungus) (Crinipellis roreri)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Basidiomycota> Agaricomycotina> Agaricomycetes> Agaricomycetidae> Agaricales> Marasmiaceae> Moniliophthora.
Aromaticity0.08
Grand average of hydropathy-0.236
Instability index49.15
Isoelectric point6.02
Molecular weight180434.49
Publications
PubMed=24571091

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP33014
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     449.83|     127|     251|    1125|    1272|       1
---------------------------------------------------------------------------
  579-  666 (79.79/40.66)	............................................INQ..RKVT...LYGLSRVYP..EESIIQAikdeiRTILPEL...........FGGQPnTSLP.TPSNISTDYNNLLsacrsdqvrIFKW..LLPPLQQTIVQ...QENEVS.
 1125- 1253 (201.76/157.86)	NV..AALDKLTTMIFHNALS.PEEANFVAQMTKGVGSE.ISGKFINNGLRRVTDV.ISRMTFTLPvlKDSLVRA.....EELLRVLIYVA.....EPLRDDP.AGLPAVGSDIQDSFLPLL.........LSKWEELSRLIQADALE...QETRVSF
 1287- 1417 (168.28/98.29)	QIlfNLLVSHATGVNADYVAyPLLLDTLYYLLDEIPNDsKAGVF..DPFRAYPDMpVSALPSDLP..HEYLLQL.....RSLLPELPTVSsianlNIAHRDP.AGQLVIGGNVVNR..P..............WEWIENLGDAPGSEpkyQESSQRF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.77|      17|      19|     255|     272|       4
---------------------------------------------------------------------------
  255-  272 (28.96/23.32)	LVDKGaFFVWLVNQ....MGSC
  274-  294 (24.81/14.40)	LAQAG.FVTRIVDEyfdgMMSC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      94.09|      27|     251|     450|     488|       5
---------------------------------------------------------------------------
  452-  484 (40.32/33.16)	TLLtWSVtplqfGDHRPFVTVTLIRHWRLKAGE
  863-  889 (53.77/25.00)	TFL.WHV.....GQHLPAGLDSQVLRWFLGPGR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      36.09|      10|      20|     788|     797|       8
---------------------------------------------------------------------------
  788-  797 (18.54/ 9.08)	DHPNLVPDVL
  810-  819 (17.55/ 8.20)	DSPSMLANGL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      37.47|      10|      28|     496|     505|       9
---------------------------------------------------------------------------
  496-  505 (18.89/11.88)	ELLQDRLFEW
  527-  536 (18.58/11.55)	ELVKHHLFSY
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP33014 with Med12 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) DLSDDLMKNENGSRTKGDLSYESKSSPMALQSRGDQRITPRGSPVSTSSHSRGSVASMRQSPGLAAPNRISSSSAAPEIIDVDSFSMSNKRKGTDDSDDDIIIVEGPNTPRNKKPKSKLPVKKTGKRR
1482
1609










Molecular Recognition Features






MoRF SequenceStartStop




1) DDDIIIVEGPNTPRNKKPKSKLPVKKTGKRR
2) DSFSMSNKRK
1579
1564
1609
1573