<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP33013

Description Ubiquitin carboxyl-terminal hydrolase 36
SequenceMPVSLAVCETTANVVNAALRESLGSCVARAALSADEAKTSNGGGDGSSTSGSSTDNLQSQIVANAKRVLLAKIDYEEVDNYHESVLAKLKSKYIVIKPDSNGGAASNGNGNYNGSNKTNGKFGAGNGHDNNGNGNGIVNGGTSALNGGNNRKQIVVVDHQSSNQHGSPSNPNELPKPKRVLYQREHIRIGWKQSERKWQVGTGMLNVGNTCYLNSSLQALFHIPSLANWLVSESAHLENCNISESCGSNGCIICAMAKTLQSTQSNQSAVRPFLIYSKLRQICKHMVVGRQEDAHEFLRFLIEAMEKAYLMRFRNYKELDQLVKETTPLNQIFGGYLRSEVRCLSCNHVSITFQHFQDLLLDIRKSDTLEDAFDGYFSRERLEDMGYKCEGCKKKVSATKQFSLERAPITLCIQLKRFSMMGNKLTKQISFKPRIDLSRFAARSPTAAAQPLSYRLVSMVTHLGVSQHCGHYTAIGLTETGSYYNFDDSCVRPIAMQSVCNTNAYIMFYELDVNGNGHVVAPKMNGMRLTTNGGQQHSSPVVATAPAAVVSATATSTSASVSAAAVTSPRFIGPQLPNGYGNSNGHALGGGAAKTAIQFKTTPQKHQQQQQAQTQYQLNGHINGAAKFQTGAANANANKSSCNTLNNSKQHQPQQQQQQPQHILPISSDEEEDSDDDNDNDNVKTNKAPQLPSMPKMFEESSESVALTAKLKPKTALKSLVPYESASEEEEQQQQQQQQTLQQQAATNSRKRRSGADSSDTDDDDDEEQQQQQQQQPSLILRNGHAKTNGNLLNSSSSKTKSASNASSANVNSSKQKTDAIDEIFKSLNNYKNKHRNDHNHVDDDDDDDEDEDEDEDEAQAQAEKKTVTKSSSSSSSTSLTNGWQQSQNGKATASPKTPPSPAVIKTKTGIWQVTRNDEDDDENVDGVADADDDDDNDEVAEPAVVTAKNHKNPFAAGKATATTDANPSAKRQKLLNGSSKSQQTTPRIGNGYQGESLPNGNAVVSELLKQNHRGYGSSVLSWNGKASELDKETFDLVCAKRIAGYGAAAADEHCCDVNSGHSSNYGTNYKSLNNDMSSSSSSSSSTNSSSNSSSRSNGNSSNCPPCDLLAEAREQRKRDDDDEEENEMDRGRQRKIKSASVKCGSGATAAPPGYNPFQEYESQKRWHSNKSGSYSRFYHHPNYRSNFQQRNKFKHNRFAGGGGGAKFQQQRALQRHLASGGGFTRRQHHQSSGQQQQQS
Length1240
PositionKinase
OrganismDrosophila grimshawi (Hawaiian fruit fly) (Idiomyia grimshawi)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Brachycera> Muscomorpha> Ephydroidea> Drosophilidae> Drosophila> Hawaiian Drosophila.
Aromaticity0.06
Grand average of hydropathy-0.873
Instability index49.90
Isoelectric point7.21
Molecular weight134996.27
Publications
PubMed=17994087

Function

Annotated function Required for maintaining multiple types of adult stem cells, including male and female germline, epithelial follicle cell and intestinal stem cells. May function as a transcriptional repressor by continually deubiquiting histone H2B at the promoters of genes critical for cellular differentiation, thereby preventing histone H3 'Lys-4' trimethylation (H3K4). Controls selective autophagy activation by ubiquitinated proteins. 
GO - Cellular Component
nucleolus	GO:0005730	ISS:UniProtKB

GO - Biological Function
Lys63-specific deubiquitinase activity	GO:0061578	IEA:EnsemblMetazoa
thiol-dependent deubiquitinase	GO:0004843	ISS:UniProtKB

GO - Biological Process
germ-line stem cell population maintenance	GO:0030718	ISS:UniProtKB
histone H2B conserved C-terminal lysine deubiquitination	GO:0035616	IEA:EnsemblMetazoa
negative regulation of antimicrobial peptide production	GO:0002785	IEA:EnsemblMetazoa
negative regulation of innate immune response	GO:0045824	IEA:EnsemblMetazoa
negative regulation of macroautophagy	GO:0016242	ISS:UniProtKB
negative regulation of peptidoglycan recognition protein signaling pathway	GO:0061060	IEA:EnsemblMetazoa
positive regulation of chromatin silencing	GO:0031937	IEA:EnsemblMetazoa
positive regulation of proteasomal protein catabolic process	GO:1901800	IEA:EnsemblMetazoa
positive regulation of stem cell population maintenance	GO:1902459	IEA:EnsemblMetazoa
protein deubiquitination	GO:0016579	ISS:UniProtKB
regulation of apoptotic process	GO:0042981	IEA:EnsemblMetazoa
somatic stem cell population maintenance	GO:0035019	ISS:UniProtKB
ubiquitin-dependent protein catabolic process	GO:0006511	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP33013
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             8|     435.32|      65|      66|     800|     864|       2
---------------------------------------------------------------------------
  555-  613 (45.03/16.86)	...............................................................TSTSASVSA.AAV.....T......SPR.F....IGPQLP........NG........YG...................................N.S........NGHalgggaakTAI...QFKTT.P...QKHQQQQQAQ
  614-  682 (56.64/23.11)	TQYQ.................lnghinGA..................................AKFQTGA...ANA.....N......ANK.S....SCN.........TLNN........SK.....................................QH......QPQQ...qqqqpQHIlpiSSDEE.E...DSDDDNDNDN
  683-  770 (46.29/17.53)	VK.............................................................TNKAPQLPS.MP......K......MFE.E....SSESVALTAK...LKP.........KtalkslvpyesaseeeeqqqqqqqqtlqqqaatnsR.KR......RSGA........DSS...DTDDD.D...DE.....EQQ
  771-  858 (94.08/43.27)	QQQQqqpslilrnghaktngnllnsssSK..................................TKSASNASS.ANV.....N......SSK.Q....KTDAIDEIFK..SLNN........YK...................................N.KH......RNDH........NHV...DDDDD.D...DEDEDEDEDE
  859-  939 (58.76/24.25)	AQAQ.......................AE..............................kktvTKSSSSSSS.TSLtngwqQ......SQN.G....KATASPKTPP..SPAV........IK...................................T.KTgiwqvtRNDE..............DDDENvDgvaDADDDDDNDE
  966- 1036 (60.87/25.39)	ANPS.......................AK..................................RQKLLNGSS................KSQ.Q....TTPRIGNGYQgeSLPNgnavvselLK...................................Q.NH......RGYG........SSV...LSWNG.K...ASELDKETFD
 1047- 1132 (41.95/15.19)	GAAA.......................ADehccdvnsghssnygtnykslnndmsssssssssTNSSSNSSSrSNG.....N......SSNcP....PCDLLAE..................A...................................R.EQ......RK..................RDD.D...DEEENEMDRG
 1133- 1196 (31.70/ 9.68)	RQRK.......................IK.............................sasvkCGSGATAAP.PGY.....NpfqeyeSQK.RwhsnKSGSYSRFYH..HPNY........RS...................................NfQQ......RNKF........KH........................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      71.94|      19|      19|     102|     120|       3
---------------------------------------------------------------------------
  102-  120 (36.42/18.98)	GGAASNGNGNYNGSNKTNG
  122-  140 (35.52/18.31)	FGAGNGHDNNGNGNGIVNG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      61.25|      18|      21|    1200|    1220|       4
---------------------------------------------------------------------------
 1202- 1219 (31.92/18.07)	GGGGAKFQ.QQRALQRHLA
 1221- 1239 (29.32/13.76)	GGGFTRRQhHQSSGQQQQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      61.11|      20|      21|     413|     432|       5
---------------------------------------------------------------------------
  413-  432 (34.63/19.44)	IQLKRFSMMGNKLTKQ.ISFK
  435-  455 (26.48/13.32)	IDLSRFAARSPTAAAQpLSYR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     125.06|      38|      38|     299|     336|      12
---------------------------------------------------------------------------
  299-  336 (64.13/37.40)	RFLIEAMEKAYL.MRFRNYKELDQLVKETTPLNQIFGGY
  338-  376 (60.93/35.22)	RSEVRCLSCNHVsITFQHFQDLLLDIRKSDTLEDAFDGY
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP33013 with Med12 domain of Kingdom Metazoa
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