<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP33013

Description Ubiquitin carboxyl-terminal hydrolase 36
SequenceMPVSLAVCETTANVVNAALRESLGSCVARAALSADEAKTSNGGGDGSSTSGSSTDNLQSQIVANAKRVLLAKIDYEEVDNYHESVLAKLKSKYIVIKPDSNGGAASNGNGNYNGSNKTNGKFGAGNGHDNNGNGNGIVNGGTSALNGGNNRKQIVVVDHQSSNQHGSPSNPNELPKPKRVLYQREHIRIGWKQSERKWQVGTGMLNVGNTCYLNSSLQALFHIPSLANWLVSESAHLENCNISESCGSNGCIICAMAKTLQSTQSNQSAVRPFLIYSKLRQICKHMVVGRQEDAHEFLRFLIEAMEKAYLMRFRNYKELDQLVKETTPLNQIFGGYLRSEVRCLSCNHVSITFQHFQDLLLDIRKSDTLEDAFDGYFSRERLEDMGYKCEGCKKKVSATKQFSLERAPITLCIQLKRFSMMGNKLTKQISFKPRIDLSRFAARSPTAAAQPLSYRLVSMVTHLGVSQHCGHYTAIGLTETGSYYNFDDSCVRPIAMQSVCNTNAYIMFYELDVNGNGHVVAPKMNGMRLTTNGGQQHSSPVVATAPAAVVSATATSTSASVSAAAVTSPRFIGPQLPNGYGNSNGHALGGGAAKTAIQFKTTPQKHQQQQQAQTQYQLNGHINGAAKFQTGAANANANKSSCNTLNNSKQHQPQQQQQQPQHILPISSDEEEDSDDDNDNDNVKTNKAPQLPSMPKMFEESSESVALTAKLKPKTALKSLVPYESASEEEEQQQQQQQQTLQQQAATNSRKRRSGADSSDTDDDDDEEQQQQQQQQPSLILRNGHAKTNGNLLNSSSSKTKSASNASSANVNSSKQKTDAIDEIFKSLNNYKNKHRNDHNHVDDDDDDDEDEDEDEDEAQAQAEKKTVTKSSSSSSSTSLTNGWQQSQNGKATASPKTPPSPAVIKTKTGIWQVTRNDEDDDENVDGVADADDDDDNDEVAEPAVVTAKNHKNPFAAGKATATTDANPSAKRQKLLNGSSKSQQTTPRIGNGYQGESLPNGNAVVSELLKQNHRGYGSSVLSWNGKASELDKETFDLVCAKRIAGYGAAAADEHCCDVNSGHSSNYGTNYKSLNNDMSSSSSSSSSTNSSSNSSSRSNGNSSNCPPCDLLAEAREQRKRDDDDEEENEMDRGRQRKIKSASVKCGSGATAAPPGYNPFQEYESQKRWHSNKSGSYSRFYHHPNYRSNFQQRNKFKHNRFAGGGGGAKFQQQRALQRHLASGGGFTRRQHHQSSGQQQQQS
Length1240
PositionKinase
OrganismDrosophila grimshawi (Hawaiian fruit fly) (Idiomyia grimshawi)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Brachycera> Muscomorpha> Ephydroidea> Drosophilidae> Drosophila> Hawaiian Drosophila.
Aromaticity0.06
Grand average of hydropathy-0.873
Instability index49.90
Isoelectric point7.21
Molecular weight134996.27
Publications
PubMed=17994087

Function

Annotated function Required for maintaining multiple types of adult stem cells, including male and female germline, epithelial follicle cell and intestinal stem cells. May function as a transcriptional repressor by continually deubiquiting histone H2B at the promoters of genes critical for cellular differentiation, thereby preventing histone H3 'Lys-4' trimethylation (H3K4). Controls selective autophagy activation by ubiquitinated proteins. 
ECO:0000250	UniProtKB:Q9VRP5
GO - Cellular Component
nucleolus	GO:0005730	ISS:UniProtKB
GO - Biological Function
Lys63-specific deubiquitinase activity	GO:0061578	IEA:EnsemblMetazoa
thiol-dependent deubiquitinase	GO:0004843	ISS:UniProtKB
GO - Biological Process
germ-line stem cell population maintenance	GO:0030718	ISS:UniProtKB
histone H2B conserved C-terminal lysine deubiquitination	GO:0035616	IEA:EnsemblMetazoa
negative regulation of antimicrobial peptide production	GO:0002785	IEA:EnsemblMetazoa
negative regulation of innate immune response	GO:0045824	IEA:EnsemblMetazoa
negative regulation of macroautophagy	GO:0016242	ISS:UniProtKB
negative regulation of peptidoglycan recognition protein signaling pathway	GO:0061060	IEA:EnsemblMetazoa
positive regulation of chromatin silencing	GO:0031937	IEA:EnsemblMetazoa
positive regulation of proteasomal protein catabolic process	GO:1901800	IEA:EnsemblMetazoa
positive regulation of stem cell population maintenance	GO:1902459	IEA:EnsemblMetazoa
protein deubiquitination	GO:0016579	ISS:UniProtKB
regulation of apoptotic process	GO:0042981	IEA:EnsemblMetazoa
somatic stem cell population maintenance	GO:0035019	ISS:UniProtKB
ubiquitin-dependent protein catabolic process	GO:0006511	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP33013
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             8|     435.32|      65|      66|     800|     864|       2
---------------------------------------------------------------------------
  555-  613 (45.03/16.86)	...............................................................TSTSASVSA.AAV.....T......SPR.F....IGPQLP........NG........YG...................................N.S........NGHalgggaakTAI...QFKTT.P...QKHQQQQQAQ
  614-  682 (56.64/23.11)	TQYQ.................lnghinGA..................................AKFQTGA...ANA.....N......ANK.S....SCN.........TLNN........SK.....................................QH......QPQQ...qqqqpQHIlpiSSDEE.E...DSDDDNDNDN
  683-  770 (46.29/17.53)	VK.............................................................TNKAPQLPS.MP......K......MFE.E....SSESVALTAK...LKP.........KtalkslvpyesaseeeeqqqqqqqqtlqqqaatnsR.KR......RSGA........DSS...DTDDD.D...DE.....EQQ
  771-  858 (94.08/43.27)	QQQQqqpslilrnghaktngnllnsssSK..................................TKSASNASS.ANV.....N......SSK.Q....KTDAIDEIFK..SLNN........YK...................................N.KH......RNDH........NHV...DDDDD.D...DEDEDEDEDE
  859-  939 (58.76/24.25)	AQAQ.......................AE..............................kktvTKSSSSSSS.TSLtngwqQ......SQN.G....KATASPKTPP..SPAV........IK...................................T.KTgiwqvtRNDE..............DDDENvDgvaDADDDDDNDE
  966- 1036 (60.87/25.39)	ANPS.......................AK..................................RQKLLNGSS................KSQ.Q....TTPRIGNGYQgeSLPNgnavvselLK...................................Q.NH......RGYG........SSV...LSWNG.K...ASELDKETFD
 1047- 1132 (41.95/15.19)	GAAA.......................ADehccdvnsghssnygtnykslnndmsssssssssTNSSSNSSSrSNG.....N......SSNcP....PCDLLAE..................A...................................R.EQ......RK..................RDD.D...DEEENEMDRG
 1133- 1196 (31.70/ 9.68)	RQRK.......................IK.............................sasvkCGSGATAAP.PGY.....NpfqeyeSQK.RwhsnKSGSYSRFYH..HPNY........RS...................................NfQQ......RNKF........KH........................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      71.94|      19|      19|     102|     120|       3
---------------------------------------------------------------------------
  102-  120 (36.42/18.98)	GGAASNGNGNYNGSNKTNG
  122-  140 (35.52/18.31)	FGAGNGHDNNGNGNGIVNG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      61.25|      18|      21|    1200|    1220|       4
---------------------------------------------------------------------------
 1202- 1219 (31.92/18.07)	GGGGAKFQ.QQRALQRHLA
 1221- 1239 (29.32/13.76)	GGGFTRRQhHQSSGQQQQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      61.11|      20|      21|     413|     432|       5
---------------------------------------------------------------------------
  413-  432 (34.63/19.44)	IQLKRFSMMGNKLTKQ.ISFK
  435-  455 (26.48/13.32)	IDLSRFAARSPTAAAQpLSYR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     125.06|      38|      38|     299|     336|      12
---------------------------------------------------------------------------
  299-  336 (64.13/37.40)	RFLIEAMEKAYL.MRFRNYKELDQLVKETTPLNQIFGGY
  338-  376 (60.93/35.22)	RSEVRCLSCNHVsITFQHFQDLLLDIRKSDTLEDAFDGY
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP33013 with Med12 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) GNNRKQIVVVDHQSSNQHGSPSNPNELPKPKR
2) IGPQLPNGYGNSNGHALGGGAAKTAIQFKTTPQKHQQQQQAQTQYQLNGHINGAAKFQTGAANANANKSSCNTLNNSKQHQPQQQQQQPQHILPISSDEEEDSDDDNDNDNVKTNKAPQLPSMPKMFEESSESVALTAKLKPKTALKSLVPYESASEEEEQQQQQQQQTLQQQAATNSRKRRSGADSSDTDDDDDEEQQQQQQQQPSLILRNGHAKTNGNLLNSSSSKTKSASNASSANVNSSKQKTDAIDEIFKSLNNYKNKHRNDHNHVDDDDDDDEDEDEDEDEAQAQAEKKTVTKSSSSSSSTSLTNGWQQSQNGKATASPKTPPSPAVIKTKTGIWQVTRNDEDDDENVDGVADADDDDDNDEVAEPAVVTAKNHKNPFAAGKATATTDANPSAKRQKLLNGSSKSQQTTPRIGNGYQGESLPNGNAVVSELLKQ
3) PDSNGGAASNGNGNYNGSNKTNGKFGAGNGHDNNGNGNGIVNGGTSA
4) YGTNYKSLNNDMSSSSSSSSSTNSSSNSSSRSNGNSSNCPPCDLLAEAREQRKRDDDDEEENEMDRGRQRKIKSASVKCGSGATAAPPGYNPFQEYESQKRWHSNKSGSYSRFYHHPNYRSNFQQRNKFKHNRFAGGGGGAKFQQQRALQRHLASGGGFTRRQHHQSSGQQQQQS
148
572
98
1066
179
1011
144
1240










Molecular Recognition Features






MoRF SequenceStartStop




1) AKRQKLL
2) AVIKTKTGIWQVTR
3) GAKFQQQRALQRHLASGGGFTRRQHHQS
4) KFKHNRFAG
5) NSRKRRSG
6) QQQQQPSLILRN
7) RFYHH
970
903
1205
1193
748
772
1177
976
916
1232
1201
755
783
1181