Description | Mediator of RNA polymerase II transcription subunit 4 |
Sequence | MSSFSQTSATFQEEFSNEITTPVKGYLVEYEGLIDQFFNAIASYSEGIKQINQTPIEIMKKIVALDKKLQKGLDLIEEHQKVHRKLLQMENEIDIENQALMDFALALKTGKEQLDICLEEARITKQAIRTAEESRVSAEEILDYANRLSQYTSAPPHYNPAIPSSMIAYPPYPDEPRMRMGLLFRQHADESFEDEDQSLEEEDEEDDEDEEPDRVMIDETHARSNSFGPVEIVQQTNQTDALNLDLNPDLEY |
Length | 252 |
Position | Middle |
Organism | Rhizophagus irregularis (strain DAOM 181602 / DAOM 197198 / MUCL 43194) (Arbuscular mycorrhizal fungus) (Glomus intraradices) |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Fungi incertae sedis> Mucoromycota> Glomeromycotina> Glomeromycetes> Glomerales> Glomeraceae> Rhizophagus. |
Aromaticity | 0.07 |
Grand average of hydropathy | -0.691 |
Instability index | 54.93 |
Isoelectric point | 4.31 |
Molecular weight | 28941.75 |
Publications | PubMed=24277808 PubMed=30271968 PubMed=29355972 |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364141 |
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro |
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro |
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro |
Binary Interactions |
Repeats | >MDP33012 --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 133.60| 45| 182| 3| 54| 1 --------------------------------------------------------------------------- 3- 54 (65.46/58.39) SFSQTSATFQEE..FSNEITTPVKgylVeyegLIDQFFNAIASYS..EGIKQINQT 191- 239 (68.14/42.21) SFEDEDQSLEEEdeEDDEDEEPDR...V....MIDETHARSNSFGpvEIVQQTNQT --------------------------------------------------------------------------- |
MoRF Sequence | Start | Stop |
1) IAYPP 2) LLFRQHA 3) RVMID | 167 182 214 | 171 188 218 |
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