<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP33005

Description Mediator of RNA polymerase II transcription subunit 5
SequenceMTANSAAPLSVDSPQSPQSPRSSGRHGSQSKPVKGRPVALSRYHIQQWANFIQRCLATRLDVDRFAQYAPLQQRKHPVSTTVLADLFLRPPAPREGQNGFSMSLLAAQTCSSPIDPRIPAYLQVLLQLGYVDVLSILRGLYRYSTSQGARKEAAATAAAIGTVRGSNGNEGSILGDSKGANGDGAGEDTDMLNNASRRSSTKKGPGGSASGAGPVLWANSYNNEETLFYRISRAVRQEDAIHRGRKALAIAACMAAWMDLFVTAASSYASATLGPADIASQQAQRQAEMEASRAAFAMLLLAVCENESVVAALAQPFAKGVRRVLANGLASFNPTISLGSAPVSARLEHFRTVTLAQFEPADKGKTNKGRGKQEEQNTATNDIHDLLDSTVGLQNLVVPEMPISNSRAGLYIYLNAVLVGRPLVDDATIFSYLNNRYQGDLQATAVDLILASFDVLANAVFRSEGQTSAHLLRSYLINKVPLLLASLAASPLYPFDSQYCISEALSRVDTNAFPTMSSMFDDNQNANTFTDSVRQDFCFACCLHGLVPEASIETLLGEITYQSLPTGGRYTKEQLVQQCLADSDYLVTLVGQLDNMDGNVGAVCQALVAMLGHLCRTRETATLKTLCNQLVRKPLAFDVLLLFERPAAILYPLCQLLDGWHYDEDQGEYQPIYEEFGSALFLLLAFVYRYNLTIADLGIQWSPDSFVARVLSTGAQGRTLVELSEQERENLGNWIRGLFNTDAGGLSDDLMSSCPPHQFYMLTPTLFQQIVQALSTGALPEDVLKGGIEYLVDTFLLPSLATALVYLSDALRVDKPAEQKAIIRILQLILQPASISDEATLMLSALLNIVAKPLEHALRTYQRQDPRSQDIDPLLKALKQNIPHSRRTAAAEHNELLNWAGTSGTNSSGSSDSANSNANNGTANNGRSNSGQGGTSGGLYAAMRQTVQGFVQWSLHPGVNIMPTSYTHRQFLAGLSLVGASSVLQLILDEVQRQTDAGSGSVAYDVACALICASDVTNEPSPDSLYVLVDGEAKAQASSNNSNNSNNNNNNSGPVTAGSTVANTAAVQRRISLRQALMFKAEEWKKIQSSHDAAGVAMAEAVVRLYRKVEAQMMPPPPPPPPPPAQTEITGLDVDDPTVAAAAAAAAGLDDTTMDSMVAAAAAAAAAGGESGGDAMVLDGVGLTSLDGTNVGGAEGNAGAAGLGTSGADGGGGAGAGSAGELGDLGDLGDLGNLDGLGDLGDLGDLGMGGSGSGTGDGKGGSLDLGDPSMFGDMDLLNSWIDYTN
Length1285
PositionTail
OrganismSporothrix schenckii (strain ATCC 58251 / de Perez 2211183) (Rose-picker's disease fungus)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Sordariomycetidae> Ophiostomatales> Ophiostomataceae> Sporothrix.
Aromaticity0.06
Grand average of hydropathy-0.118
Instability index40.85
Isoelectric point4.89
Molecular weight135751.79
Publications
PubMed=24855299

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP33005
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      42.08|      13|      15|    1220|    1232|       1
---------------------------------------------------------------------------
 1211- 1231 (20.29/ 6.61)	GggagagsaGELGDLGDLGDL
 1232- 1249 (21.79/ 7.59)	G...nldglGDLGDLGDLGMG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      70.10|      17|      17|    1131|    1147|       2
---------------------------------------------------------------------------
 1134- 1150 (26.11/11.03)	VDDPTVAAAAAAAAGLD
 1154- 1170 (24.02/ 9.52)	MDSMVAAAAAAAAAGGE
 1171- 1187 (19.97/ 6.59)	SGGDAMVLDGVGLTSLD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     105.44|      31|      95|     533|     626|       3
---------------------------------------------------------------------------
  533-  569 (51.11/24.74)	VRQDFCFACCLHGLVPEASIETLLgeityqSLPTGGR
  631-  661 (54.33/111.49)	VRKPLAFDVLLLFERPAAILYPLC......QLLDGWH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     168.41|      57|     263|     699|     762|       4
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  700-  762 (95.27/67.63)	QWS........PDSFVARVLSTGAqgrTLVE........LSEQERE.NLGNwirGLFNTD.AGGL..SDDLMSSCPPHQFYML
  952- 1028 (73.15/35.59)	QWSlhpgvnimPTSYTHRQFLAGL...SLVGassvlqliLDEVQRQtDAGS...GSVAYDvACALicASDVTNEPSPDSLYVL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     223.27|      98|     264|      46|     239|       6
---------------------------------------------------------------------------
   46-   98 (57.83/157.88)	..............................QQWANFIQRCLATRL.DVDRFAQY..APLQQRKHPVSTTVLADLflrPPAPREGQN.....................................................................................................................
  190-  214 (11.60/29.31)	......................................................................................gfsmsllaaqtcsspidpripaylqvllqlgyvdvlsilrglyrystsqgarkeaaataaaigtvrgsngnegsilgdskgangdgagedtDM.LNNASRRSSTKKGPGGSASGAGP
  217-  284 (63.23/19.80)	WANSYNNEETLFYRISRAVRQED.......................................................................................................................................aihrgrkalaiaacmaawmDLfVTAASSYASATLGPADIASQQAQ
  285-  367 (90.62/ 0.00)	RQAEMEASRAAFAMLLLAVCENEsvvaalaQPFAKGVRRVLANGLaSFNPTISLgsAPVSARLEHFRTVTLAQF...EPADKGKTN.....................................................................................................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      40.63|      13|      15|     779|     793|       8
---------------------------------------------------------------------------
  779-  793 (18.59/18.63)	LPEdvLKGGIEYLVD
  797-  809 (22.04/13.75)	LPS..LATALVYLSD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      82.55|      17|      64|    1188|    1204|       9
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  165-  175 (21.15/ 6.72)	GSN.....GNEGSI.LG
 1188- 1204 (31.18/13.48)	GTNVGGAEGNAGAAGLG
 1250- 1266 (30.22/12.83)	GSGSGTGDGKGGSLDLG
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP33005 with Med5 domain of Kingdom Fungi
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