<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP33004

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMEVGDYETNTLAVNNIASIAFRVYRPVAAASASAALFTFSPSDVEKALRHDGHLVFADSRRQGIWCFRLLRKDGSPIGSPTKSELGTTIDVGPYKLTTVSDGTFDPGSLVLGKPAASTSANPVNTPSSSASSSATSIALHTSFGLSGLPGVVDAPASQAQGTAGSNGGADRDGTPNGGTAHVAHAAHAAQGTQGTQGGSQTQAQASDPRSAFPAVPTKVVYNFFMSAVLASLSTAYCSNAKAIALNNRTFLLPPLDPLWDGRESSRTDSRSLVATLRITLTTAGALLVSLSHSLLRGMGCSEWECYAGVPPPGSAVLTAPWGKFATVQDAYPPVMSADDSRYAVARLQRNGVPLPAVPHVWKSFAAKMLEMRGTSASVLQDSTWLQLEFVLDDKTPNGNDSDNSGGNSVVILWPSVLCFWCLEDALVTVAPFQRLDPLAELREAYLEELRAEEAALRSKEAAKEEDVAPEDVVMEDVQTVSSIGKGTQSDGPSPVGLRHNLVGPGGPGGPGGAGGAGGAGGAGATSATSATSAAGAIYPTPPDGILSLVGATPTFDGATSSPGNAMGPSAGPADLDAIPAERPSGAEEGFGDWPSIGAQQNDQDQDQAFMGEPDNLLGGDLGADMFGDDITDADFNFFDDTKQADAATAASATGAAGPSALAPDKMDVDVSSRPSEMPADDTLPDAHAQPMSQADSNIQSESQPQPQPQNQNQNQNQNTPSMPPPPPPVQQPPSDRKSNETVGESSNKTPGSPVFAKPELRHARSNLSDARKGSGKRSPSPFNAVTVFKRVRAIAEANKALPVGALRQPRPQQPGKLFEGLKFTEFMIQNSKKYELNGKFGFSWPHPEADMLSDLSSATSPTAFRRPLKKRPGLSDASPQFASLISSITRGLKSSSLHAAPSPRLLEDLEDGGDTSSNASSTSSSSDDSDDDEAPLAVTAVHRKMRARAMAELIPSPEAATELSRAYSEGVWDFPIARFFAEPLPQPTELNYADDDIADVAQILTQQITRATIRSVFDEDDGQNLQKSKLRQTLLQRVRYSVATLEDSLPASLDGASRCALKPYLDVQDALQLAPPGRLHPRAPPGSEQRIPNLFPAPTPLVGIRRNESTLSIKPTGIEFWEVLGLEPLHGPKDIRAVCAYPNYQGLSSDVARFLDRMRIVYESLRLGAHEPLSFKASVVDGMVAFNSSLSSSSPLSQSTPGAEFSGVDQVHKLAQALAAEDSPGKSLVVYFVYCPEITTAIVDACLAFQRLSQLYDIAVTSRSSEPNDLVLQLIPADFLSSPTSLAVPTPTDLLRLSLEVYDRCASLRGPKPAPAFLLEQPPARNLDLKLSSTPLVDVQRENSCIHVAYAASADERWITAAWTDNSGWRQFSSAYWIGRKDARDAANSFDAVAREIWTNTCAIVSNLKVHWRAIVAKCGHMDPDEISIWSELAKAETRASISLTLVSADTQPTLELLPPIATVAPTVLSQLSVQTLAQTPQASVFSPEQSGNPVTPAGGSFANNPTTPAAGTPAGGGPTPATPGGGQLGKAGVAAPNSPAIPNTPSGAGASANATATTAAVANANANANAIANANASSNANNDASAKLAAAGADPNTVVDIEGNVVLVDVTDNTWIAVAAHRLNTASTWVDLQPALVSGYLIKRGGIGRDDAPVVLEVNIVHVDPKHRVSDALARDILTSYRALGTLARVRGILDSERDARPWHIAAAERAARALCRWM
Length1720
PositionKinase
OrganismSporothrix schenckii (strain ATCC 58251 / de Perez 2211183) (Rose-picker's disease fungus)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Sordariomycetidae> Ophiostomatales> Ophiostomataceae> Sporothrix.
Aromaticity0.06
Grand average of hydropathy-0.252
Instability index46.46
Isoelectric point5.05
Molecular weight180669.42
Publications
PubMed=24855299

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP33004
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.64|      15|      19|    1551|    1569|       1
---------------------------------------------------------------------------
 1551- 1569 (20.15/17.42)	ASANATATtaavANANANA
 1571- 1585 (26.49/13.14)	AIANANAS....SNANNDA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      96.75|      20|      20|     842|     861|       3
---------------------------------------------------------------------------
  687-  704 (29.84/14.26)	HAQPMSQAD..SNIQSESQP
  842-  861 (38.80/21.14)	FSWPHPEADMLSDLSSATSP
  864-  879 (28.10/12.93)	FRRPLKKRPGLSD....ASP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      62.39|      19|      21|    1272|    1291|       5
---------------------------------------------------------------------------
 1272- 1291 (28.66/22.03)	LQLiPADFLSSPTSLAVPTP
 1295- 1313 (33.73/21.18)	LRL.SLEVYDRCASLRGPKP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     151.93|      27|      27|     144|     170|       6
---------------------------------------------------------------------------
  119-  141 (29.23/10.14)	....SANP..VNTPSSSASSSATSIALHT
  144-  170 (48.50/22.22)	GL..SGLPGVVDAPASQAQGTAGSNGGAD
  173-  200 (38.47/15.92)	GTpnGGTAHVAHA.AHAAQGTQGTQGGSQ
  512-  536 (35.72/14.20)	GA..GGAGGAGGAGATSAT.SATSAAGA.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.15|      17|      21|    1182|    1202|       7
---------------------------------------------------------------------------
 1160- 1177 (24.67/ 9.94)	IVYESlRLGAHEPLSFKA
 1184- 1200 (27.48/12.95)	VAFNS.SLSSSSPLSQST
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      87.42|      20|      21|     733|     752|       9
---------------------------------------------------------------------------
  708-  732 (29.53/16.08)	PQNQNQNQNQNTP..SMPPPpppvqQP
  733-  752 (32.05/18.22)	PSDRKSNETVGES..SNKTP.....GS
  753-  774 (25.84/12.94)	PVFAKPELRHARSnlSDARK.....GS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.68|      17|      20|     884|     902|      10
---------------------------------------------------------------------------
  884-  902 (22.59/18.24)	LISSITRGLKSSSlhAAPS
  905-  921 (28.08/15.47)	LLEDLEDGGDTSS..NASS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.82|      13|      20|     948|     965|      11
---------------------------------------------------------------------------
  948-  963 (19.38/18.73)	RAMAELIPSPeaaTEL
  978-  990 (26.44/ 9.52)	RFFAEPLPQP...TEL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.92|      17|      21|     994|    1013|      12
---------------------------------------------------------------------------
  994- 1013 (19.66/28.45)	DDDiaDvAQILTQQITRATI
 1018- 1034 (29.26/23.67)	DED..D.GQNLQKSKLRQTL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      30.55|      10|      15|     813|     823|      14
---------------------------------------------------------------------------
  813-  823 (15.79/17.43)	QPGKLFE..GlKF
  829-  840 (14.76/ 9.04)	QNSKKYElnG.KF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     151.12|      45|     269|    1336|    1383|      15
---------------------------------------------------------------------------
 1336- 1383 (75.53/58.17)	LVDVqRENSCIHV.AYAASADERWITAAWTDNSGWrqFSSAYWIGRKDA
 1608- 1653 (75.59/47.40)	LVDV.TDNTWIAVaAHRLNTASTWVDLQPALVSGY..LIKRGGIGRDDA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      41.15|      11|      20|    1053|    1063|      16
---------------------------------------------------------------------------
 1053- 1063 (19.98/ 8.73)	LDGASRCALKP
 1071- 1081 (21.17/ 9.72)	LQLAPPGRLHP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     108.64|      26|      27|     546|     571|      17
---------------------------------------------------------------------------
  481-  506 (25.67/ 8.75)	.SSIGKG.TQSDG..PSPvGlrhNLVGPG.G
  546-  571 (48.94/24.44)	LSLVGAT.PTFDGATSSP.G...NAMGPSAG
  575-  597 (34.03/14.39)	LDAIPAErPS..GAEEGF.G...DW..PSIG
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP33004 with Med13 domain of Kingdom Fungi
Unable to open file!