<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP32995

Description Uncharacterized protein
SequenceMASESSQSQVSPPVPPLPSGGRRMDDAQPQQPRGNDKQLSQMQVLQQRILQQQMKMQKQQRLQQLQQKQQHQKQQQQKQHIQQIQKQMAHKQKQQQPQHTPQSPSQSQSQSQPQAQSQPQQPGSNDGAQHHKPRQKSAKKQLQKQAPPLFARAQRVDGYSISRGLRKDGLYRSLNTEPETEASFAASHPPSHPPSQPQPLPLSHSSDQGLSSGAATPKSIGTDASDPSSRTSKSSKSELPICSSRGRAPFNEFSWAIEPPRNDVDVPPTTPTTTPQAGSASSPTGTPSAGSNGGSLRASMFKKSTTLAYGSGSSSGNQKDADGVDKDGLAKPWHLDVPPGIPYYVVPSTGRRLGALTKGGSRNFAQSPTQAQQKGSSGNGTRTGASPFANSRTVSGSGSFGANGSASPSGTNNTAVRNNGNNRNKSAGGVGSKSPSAANRVQKPAVRYLDFNPWKGRHLEDRLTDSTVRMGQYDRLPNPQSHTTETTSARAWLPLLLRQKNSTMVLGQALALANALSREKNHIPPASQFKLPPRVTVTDTRRETWLRDLTNAGIPLRKLSRTIPHGLRGKVLLEQCMLKSVPVDRAMWLARCVGAQELRAFKRKGTANVSALAESELRWLKDWTLTVQQFVEAFLVEINLEKGTGEERLQYAARFARQLYLERLLDHDQFLNWMLVGLRNAARLPAAASVSTPYFDLWLFIVEEYFHGIMQRRKTSAHLAVSILSRLEFLSHFQSGPISSAQAKKLLQIMVQSHPDAFVSHPVWPRYETLLHTTLLPAPSPSAPEQPPPALLDAVSTIRHRNDCLRPETSAEMDQVVNYLQPLDSALRCPTDFASHFAEFLRLDKRETVPFVIRWCASIHRPGLAKIYIAARLIGELCQMDAKLATNYMLGFLSSDRKTASARNHTANDSGSRKKSTSTALSKSRQATLQTIQDQQPEGNKALYQLVGLLVAQDLFLPAHYLASLILQSRPSDADEIIPEGRPHVRLVAELPVHLLNQSTSSLRANHLRRLGYDTEYESQDTERILDQVQKAFTEMAAAAQTIPVTTNTADETPGSTMTAASPVGIVAAEPPREARAAASVIKLARTVENRSRNVKMAVADWLQKNVVTAMRTYSKLVMGEIDGYGANLGPVGVRRPSSKADTVAAPNGNGQLPPYATNPANLSLERVNAVRSLIEKTDDLRLLSEFILAVASYPQSISVMALCADTINLYLGAFLAMGNARTLYDKVMARALAITVRVDSGANTAYQTLLPPGTDVRPLLLALPALAEKMPQPGPGSVMLGVNGQPIRLIPKAASALGGASKNGASSGTREELMKKHFEVGTAMATDIQTRLLQIDQRLSVATYDADCSPLSDGRAAHVPQEDADADEVREEMVKLASSSSSSIDSTTMDNLFGTIAMISQGRWRRIQPDGDLAAQARTRDDYRLSGSLFARLRRFNPAHFDTIMVKWLKRLRTMRDRPAIGTLYPVFVVFGCLDLASLLATTADEQPREAGAMIQSPARNTWRTSYLQDVLTLLSVPIADSHPVLTCDECQRFRVFQDEALYVAPAGIAALIRNAIAEMTLWRHHQRQTSQGLVAMQPASGAVARNPINALSVSRLLRSAAFADAHKAGIALAKTTDQTVRSGLWEMMTLALTRQVAPGRSPLEMLRGLDIFAADAGQVALGLIVSPGPYASAAERTKEADNLANLILRAVSEFQFATLSVLHSLPSDMATSLKDHAQTRFLDTVPTRKHLTAMSSTPSTPAIGTTGGSDNGFGNGFDVASGFLNIVRTILLNHQQQFQKKLEQQQQQQQSTTVTTTGSGAANTQLPPPPSPGLLPASGIPPLDSSVVDKLGELWCLLQEPTSAAARKDKDLPAIDAERIVNLKHAILRDWLPALLSLILLHLPNRDALLLSIDGIHGSGFGGSGSVMAALVRTDSSKLPGSQGASPATFSSPANSTAATVGMNMVTNFNAVTSNNFGVGAASVGSNHGATPGGGVGGVAGLARTSRDHEQEAVYAGACIALASLYVEVSSLADNGDAAVVGHGQGSTSSTTTTTTSAPSATASAPSATNSSANATMEGSCGHRLALQSRLFDTALLLADSLSDEMRQHCVRALRDAVASRDGGVGGDLQPVMAYILSSPVSASIYYPHLVLERLPQISLFGRAPPAPTPRERSNASDRGTSANASQATTGTAASATPTPGAPGGTAAPPPGPPRRMASGMGYGGFFGLTGTNQTKRVRFGLKTWDAVSDPSPAVQDNDTAVNLWLLEATKVVRQRRR
Length2260
PositionKinase
OrganismSporothrix schenckii (strain ATCC 58251 / de Perez 2211183) (Rose-picker's disease fungus)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Sordariomycetidae> Ophiostomatales> Ophiostomataceae> Sporothrix.
Aromaticity0.05
Grand average of hydropathy-0.361
Instability index51.06
Isoelectric point9.61
Molecular weight243034.95
Publications
PubMed=24855299

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. Component of the srb8-11 complex. The srb8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The srb8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP32995
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     317.52|      66|      69|     211|     278|       1
---------------------------------------------------------------------------
  125-  204 (57.57/18.02)	NDGAQHHK........PR....Q...KSAKKQLqkqapPLFAraqrvdgysiSR...GlRkdglyrslntE.............PETEASFAAsHPPSH....PPSQP.QPLPLSH
  211-  278 (113.11/44.98)	SSGAATPKSIGTdaSDPSS.RTS...KSSKSEL.....PICS..........SR...G.R..........A.............PFNEFSWAI.EPPRNDVDVPPTTP.TTTPQAG
  281-  350 (64.80/21.09)	SSPTGTP.SAG...SNGGSlRASmfkKSTTLAY.....GSGS..........SS...G.N..........QkdadgvdkdglakP.....WHL........DVPPGIPyYVVPSTG
  365-  428 (82.04/28.44)	AQSPTQAQQKGS..SGNGT.RTG...AS..........PFAN..........SRtvsG.S..........G.............SFGANGSAS.PSGTNNTAVRNNGN.NRNKSAG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|    1243.35|     496|     902|     513|    1312|       2
---------------------------------------------------------------------------
  539-  796 (194.24/861.69)	DTRRETWLRDLTNagipLRklSRTIPHGLRGKVLLEQCMlksvpvDRAMWLARCVGAQelrafKRKGTANVSALAESELR..WLKD.WTLT...............VQQFvEAFlveinlekgtGEERLQYA....ARFARQLYLERLL..DHDQFLNWMLVGLRNA....ARLPAAA.SVSTpYFDLWLFiVEEYFHGIMQRRKTSAhlavSILSRL.EFLS...HFQSGPISSAqakklLQIMvqSHPDAFVSHPvwprYETLLHTTLLPAPSPSAPEQPPPA......LLDAVS....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................
 1015- 1312 (347.12/238.26)	.........................................................................................................................................................................................................................................................................................................tirhrndclrpetsaemdqvvnylqpldsalrcptdfashfaeflrldkretvpfvirwcasihrpglakiyiaarligelcqmdaklatnymlgflssdrktasarnhtandsgsrkkststalsksrqatlqtiqdqqpegnkalyqlvgllvaqdlflpahylaslilqsrpsdadeiipegrphvrlvaelpvhllnqstsslranhlrrlgydTEYESQDTERILDQV..QKAFTEMAAAAQTIPV.TTNTADETPGSTMTAASPVGIVAAEPPreARAAASVIKLARTVENRSRNVKMAVAdwlqknVVTAMRTYSKLVMGEIDGYGANLGPVGV................................RRPSSKADTVAAPNGNGQLPPYATNPANLSLERVNAV.RSLIEKTDDLR.LLSEFIL.............AVASYPQSISvmALCADTI.NL.......YLGAFLAMGNARTLY..DKVMARALAITV..RVDSGANTAYQTLLPP.GTDVRPLLLALPALAEKMPQPG.PGSVMLGVNGQPIRLipkaASALGGASKNGAsSGTRE
 1443- 1880 (415.14/96.15)	DTIMVKWLKRLRT....MR..DRPAIGTLYPVFVVFGCL......DLASLLATTADEQ.....PREAGAMIQSPARNTWRtsYLQDvLTLLsvpiadshpvltcdeCQRF.RVF..........QDEALYVApagiAALIRNAIAEMTLwrHHQRQTSQGLVAMQPAsgavARNPINAlSVSR.LLRSAAF.ADAHKAGIALAKTTDQ....TVRSGLwEMMTlalTRQVAPGRSP.....LEML..RGLDIFAADA....GQVALGLIVSPGPYASAAERTKEAdnlanlILRAVS........................................................................................................................................................................................................efqfatlsvlhslpsdmaTSLKDHAQTRFLDTVptRKHLTAMSSTPSTPAIgTTGGSDNGFGN..............................................................................gfdvasgflnivrtillnhqqqfqkkleqqqqQQQSTTVTTTGSGAANTQLPP.PPSPGLLPASGIPPLdSSVVDKLGELWcLLQEPTS.............AAARKDKDLP..AIDAERIvNLkhailrdWLPALLSL....................................................................................................
 1940- 2216 (286.84/-314.00)	............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................AATVGMNM.VTNFNAVTSNNFGVGAASVGSNHGATP..GGGVGGVAGLARTSRDHEQEAVYAGA......CIALASLYVEVSSLADNGDAAVVGHGQG................................STSSTTTTTTSAPSATASAPSATNSSANATMEGSCGHrLALQSRLFDTAlLLADSLSdemrqhcvralrdAVASRDGGVG.....GD.L.QP.......VMAYILSSPVSASIYypHLVLERLPQISLfgRAPPAPTPRERSNASDrGTSANASQATTGTAASATPTPGaPGGTAAPPPGPPRRM....ASGMGYGGFFGL.TGTNQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      90.94|      20|      20|      61|      80|       3
---------------------------------------------------------------------------
   61-   80 (37.69/20.68)	RLQQLQQKQQHQKQQQQKQH
   82-   99 (26.68/12.25)	..QQIQKQMAHKQKQQQPQH
  100-  118 (26.57/12.17)	TPQSPSQSQSQSQPQAQSQ.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     134.96|      40|     902|       2|      42|       4
---------------------------------------------------------------------------
    2-   42 (68.57/35.36)	ASESSQSQVSPPVPPLPSGGRRMDDAQPQQPRGNdKQLSQM
  907-  946 (66.40/30.45)	ANDSGSRKKSTSTALSKSRQATLQTIQDQQPEGN.KALYQL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP32995 with Med12 domain of Kingdom Fungi
Unable to open file!