<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP32994

Description Mediator of RNA polymerase II transcription subunit 17
SequenceMADNRPRPVARPGAASTASASTSASTSASGGPLAPPPPPPPPPPPPISGPLFGTRDPVFRPWPLPSKQPTNIGEFVQRLKFQGIDFRDLSEEKLRKQIEKEKAEEDEEEEEKNGGGTTKTAVTTKRKSSDKNGAKRDTSHDRPRSIQEMLAKRDEILMSLEAALQSGLIAVDFVSLLLSKDRPTQALQTLSPIVRDKAGIGTLSAGRIANAAQAARALQSQNGGGGGGRGGASGLSAAEVQALDETTRFNAQRLIEHKTECVGWQLLAMDRASDVLRAGRKRLRTEMRREERYWSEVLAVRDKGWTLSRMPGQRRVLRVKFGFSESAPDLRALSFAPLRRVKNGQVALDLSALGAPSAIVVTLRKKGASTTHQGPAQVGRSPLATRLAASASLEDRILEARNTVNAKELWRELNREARLMLSHGVVFRDAEIVFPAGANIEGVITIEPLYRRPSAHTSAAEKKKREAEATHDPKLNDIAAGICTSLQLFLAHGHRDHYRQRSSPQPITDTEPQPPIYYMLRPIVANLKYEKAIQHISGYLSDVCGILHGLGLDGSRFTLYERPLSMSIAPPGTAAPRPGQAGQAGQGGQPAQAAPSASEGLCNTFLAPREFSFEFTINPEVRILVRCRTTVVPLKAQYLIQLLPPSSPAATASPLAPPAPPAARNPLFDTFPPADNYGTLRDVLDYLSRATAHVLAAHARKLARQWEDRSGMGTAWATSVDGMEIRQLNNAFWKVRFSLVPQSAITALDKLVAVSEKGGGAPAKEEPVPFSIENDEDDYVDETAQVAAAVAAADLGGDDDSDDDGTDNGTDNVVLDDATQDRENARNVDSPLARPSPPELRVYASWPMEESESAVYRKWVWSSASLEAHAAGTPDDLESVVVGCVSGNLKPIVGIRLR
Length898
PositionHead
OrganismSporothrix schenckii (strain ATCC 58251 / de Perez 2211183) (Rose-picker's disease fungus)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Sordariomycetidae> Ophiostomatales> Ophiostomataceae> Sporothrix.
Aromaticity0.05
Grand average of hydropathy-0.436
Instability index52.39
Isoelectric point8.06
Molecular weight96989.27
Publications
PubMed=24855299

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU364140
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP32994
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     146.84|      46|     107|     620|     665|       1
---------------------------------------------------------------------------
  620-  665 (85.39/37.89)	EVRIL....VRCRTTVVPLKA.QYLIQLLPPSSPAATASPLAPPAPPAARN
  724-  774 (61.45/25.35)	EIRQLnnafWKVRFSLVPQSAiTALDKLVAVSEKGGGAPAKEEPVPFSIEN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      37.11|      12|      16|     126|     137|       2
---------------------------------------------------------------------------
  126-  137 (21.71/12.18)	R.KSSDKNGAKRD
  142-  154 (15.39/ 6.71)	RpRSIQEMLAKRD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      33.33|      10|      18|     327|     337|       3
---------------------------------------------------------------------------
  327-  337 (14.90/12.93)	APDLRALSfAP
  347-  356 (18.43/ 9.85)	ALDLSALG.AP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      60.35|      19|      20|     273|     292|       4
---------------------------------------------------------------------------
  278-  298 (26.63/14.79)	AGRKRLRTEMRREERywSEVL
  299-  317 (33.72/15.18)	AVRDKGWTLSRMPGQ..RRVL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     172.92|      43|     113|     449|     491|       5
---------------------------------------------------------------------------
  449-  491 (71.08/47.49)	LYR..RPSAHT.....SAAEKKKREAEATH.DPKLNDIAAGICTSL.QLFLA
  516-  552 (42.04/24.55)	IYYmlRP..........IVANLKYEKAIQHiSGYLSDV.CGILHGL.GL...
  559-  607 (59.80/38.58)	LYE..RPLSMSiappgTAAPRPGQAGQAGQ.GGQPAQAAPSASEGLcNTFLA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      71.74|      16|      22|      32|      52|       6
---------------------------------------------------------------------------
   32-   47 (38.33/11.80)	PLAPPPPPPPPPPPPI
   57-   72 (33.42/15.27)	PVFRPWPLPSKQPTNI
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP32994 with Med17 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) MADNRPRPVARPGAASTASASTSASTSASGGPLAPPPPPPPPPPPPISGPLFGTRDPVFRPWPLPSKQPTNIGEFVQR
2) SEEKLRKQIEKEKAEEDEEEEEKNGGGTTKTAVTTKRKSSDKNGAKRDTSHDRPRSIQEMLA
3) VAAADLGGDDDSDDDGTDNGTDNVVLDDATQDRENARNVDSPLARPSPPELRVYASWP
1
90
790
78
151
847










Molecular Recognition Features






MoRF SequenceStartStop




NANANA