<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP32993

Description Mediator of RNA polymerase II transcription subunit 6
SequenceMSFKIDELQWSEPETANEMQGIHSNSVLYYFMRSPYFDKTSNNNTVYNQALHNHNMFPVLETRERFEDFLRSMSGVEYIVHQAPAEMAPGTGTGVWVIRKQLRRKRNDGQPDDLTVYADYFVVGYNIYQAPTLADVLSSRITSMAVALGKAFPAMNSMQTWSPAEGHYYETTGKAVAAAAAAGEDGLVENQALRDEPDDEDQGVEEDEEEDEEEDEEEDDEDDDSDEDAMDVDKTETTTRDKGAHDDADSEDDADDDMLDPRLAEESYAIHMMYGGEYMDEQPISGRPGDFHIALAGGGRSAVGGAAGAARGKATADAADATKDGTGSGKATPKDGKEAQKSGAATPKPKRRKSKGAAA
Length359
PositionHead
OrganismSporothrix schenckii (strain ATCC 58251 / de Perez 2211183) (Rose-picker's disease fungus)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Sordariomycetidae> Ophiostomatales> Ophiostomataceae> Sporothrix.
Aromaticity0.07
Grand average of hydropathy-0.861
Instability index50.57
Isoelectric point4.35
Molecular weight39170.94
Publications
PubMed=24855299

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU364143
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP32993
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      69.52|      14|      16|     312|     325|       2
---------------------------------------------------------------------------
  173-  186 (23.47/10.12)	GKAV.AAAAAAGEDG
  312-  325 (26.14/11.96)	GKAT.ADAADATKDG
  329-  343 (19.91/ 7.66)	GKATpKDGKEAQKSG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      70.66|      22|      26|     210|     231|       3
---------------------------------------------------------------------------
  210-  231 (39.69/18.57)	EDEEEDE.EEDDED..DDSDEDAMD
  236-  260 (30.97/12.93)	ETTTRDKgAHDDADseDDADDDMLD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.72|      16|      20|     270|     289|       7
---------------------------------------------------------------------------
  270-  289 (26.79/23.19)	IHMMYGGeymdEQPISGRPG
  293-  308 (26.93/13.13)	IALAGGG....RSAVGGAAG
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP32993 with Med6 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) AAAAAGEDGLVENQALRDEPDDEDQGVEEDEEEDEEEDEEEDDEDDDSDEDAMDVDKTETTTRDKGAHDDADSEDDADDDMLDPRLAEESYAIHMMYGGEYMDEQPISGRPGDFHIALAGGGRSAVGGAAGAARGKATADAADATKDGTGSGKATPKDGKEAQKSGAATPKPKRRKSKGAAA
178
359










Molecular Recognition Features






MoRF SequenceStartStop




1) DMLDPRLAEESYAIHMMYGGEYMDEQPI
2) RPGDFHIALA
3) VGGAAGAARGKATADAADATKDGTGSGKATPKDGKEAQKSGAATPKPKRRKSKGAAA
257
287
303
284
296
359