<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP32992

Description Mediator of RNA polymerase II transcription subunit 16
SequenceMAEDIPLILDDAMSGIAGMSGDVPVGLGDVDVDDVDLFGGPVDLSLPSHRPPSKQLQLRIDEQRIRGCNQRIAWSKQGTIASIGADGQSIELRYLRTDAEDASWALSEATSYAHFSSINTQTTFAGGPIVHLAWAATGHSELAVIDSVGRVSILAFSTSLNKPFALRSWEADPVDDLRAVVGCYWLPIVPANKQYNVIYGPAVREESGYRYETTLVHASGPYHPNPNKSALLCVTVSGTLRLLFSQNSNQVQDTSIELENITSSDDLTSHASICTDKNMLLIAMVTASRQLKVVRAAIGWNQSQQDKQAPLQSQQLNPMLQHKPTAVTTWLQHSGGESQLDISSDLVSHVEMLPSALSTGANHWSQPLVIVVREYLPTQSTASYNPEPQSIIDRWELVTESPPQPLHPAFEQLGFKPTQSTPQTGSQAHTRLNKLPPVTINKLIISIQNLHHGRVVCFFFSDGTLQYRDRFTFEEVFNEPNPARIASLQHASFQFSDPTPCLAAVLSPTNCSFAQVCEDGKVKWNNLKYTGPDLAPTGPDPNYTAIVAGLTTAVSTSSANIISYDDILATARQFINRPRFAYEWMMEIVRILKINVDYSEDAHHDQLVRNNSLHLCLSILNHLGFRGEFKPRSFYGKFSMLALNMRNIVILITISSNAPSNLKVNPLDEPDVVDALAGCAKWAVDFLAYTCDCIFNLLDDPKFQSFLTGNNFNEMVPYLLEKNEIALHLILCSSTRGFLSAACRRLLHLDSISSRATKFYEQQQQTPTGAANGNSSLRPALIMAYQKMQQYTSSSLIKVQEFDKLLWALGEDIRHTYQSTAAAQSGAAAKNRGQNQGQNQGQNQATDNAAKRFQAHCELTLLLANNPPAHFQPLLRKFFNTNVRQFRTLTDPAKLYFADYSILDVEDDNRSLQEKRARHTHIDVFKRVELKPTSSTSGASGSSAANAAGHPTTFPPHSAPSEYYRRCARCTSIMEDITGSRPGYTFVLAQQRKCSCSGNWGLLPRSAFVG
Length1010
PositionTail
OrganismSporothrix schenckii (strain ATCC 58251 / de Perez 2211183) (Rose-picker's disease fungus)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Sordariomycetidae> Ophiostomatales> Ophiostomataceae> Sporothrix.
Aromaticity0.08
Grand average of hydropathy-0.266
Instability index43.08
Isoelectric point6.30
Molecular weight111525.54
Publications
PubMed=24855299

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP32992
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     246.57|      77|     299|      77|     157|       1
---------------------------------------------------------------------------
   77-  157 (117.92/95.10)	QGTiASIGADGQSIELRYlRTDAEDASWALSEATSYAHFSSinTQTTFAGGPIVHLAW....AATGHSELAVIDSV..GRVSILAFS
  379-  461 (128.65/87.92)	QST.ASYNPEPQSIIDRW.ELVTESPPQPLHPAFEQLGFKP..TQSTPQTGSQAHTRLnklpPVTINKLIISIQNLhhGRVVCFFFS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     104.38|      33|     299|     597|     633|       2
---------------------------------------------------------------------------
  597-  633 (57.72/53.45)	DYS.EDAHHDqlvrNNSLHLCLSILNHLG.F.RGEFKPRS
  899-  934 (46.66/32.96)	DYSiLDVEDD....NRSLQEKRARHTHIDvFkRVELKPTS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     253.00|      77|     494|     159|     240|       3
---------------------------------------------------------------------------
  159-  240 (134.11/117.30)	SLNKPFALRSWEADPVDDLRAVVGC.YW...LPIVPANKQYNVIYGPAVRE.ESGYRYETTLvhasgPYHPNPNKSAL...LCVTVSGTL
  655-  739 (118.89/91.46)	SSNAPSNLKVNPLDEPDVVDALAGCaKWavdFLAYTCDCIFNLLDDPKFQSfLTGNNFNEMV.....PYLLEKNEIALhliLCSSTRGFL
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP32992 with Med16 domain of Kingdom Fungi
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