<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP32985

Description Mediator of RNA polymerase II transcription subunit 17
SequenceMSTTHISLEPPAITAQDGLDDDLFAPAARLYEVTHDGQQVLTREDSNKLPTERLLRIWQERGDFSQLTSQRIRDEQNKDLTKTSSTDEHSGEQDEHKDDVHELGITPEQMSELRMTMMRQLELARGELTTALDLLSIIAAPTVATTVDAEALPLPQQTLTIVPSAPPIPLPSSENDDSTNEHTGASTSLLPLATSLASLRESANSFFSASSQVLASTSNSTTSTSTSPSRNPTSKQWSTLLHLHTSTPFPLIPLGARSNASFSGQGETRLAKQVGVFYGCAEAAPSFRRAGVAQVEQVLQEVEEGREGLGKGVGRKTGRKLVVEVEMEGRGRDWCVWTSGAAEKEGKEQGVEDMLKQRGRNVFAEELFAVLSNEARSDVSVKSRLELGKRSQGDSVITEGHGWKLKITMVAVPEPKLEAPIPEPNAIAPLLVPLLRLLLIQEYVRRRSPTSFSTSIPILPTVSAFLSYLYRLNSLCGVLTTLTSTIDPSIPTSTTYHPSLASAPLSAVRKILSPPTTSNELKELGGRIVLRIGSSPTSLFHISHSTLLPQPSSTSTTNPSTSPSPSMGVSAFALASHQGLVLQAPRSAPVVVGSVGQLKGFLQEQIGEVLKGCAGKEEVEEVNGKEKEGMEVDQSSLV
Length638
PositionHead
OrganismMicrobotryum lychnidis-dioicae (strain p1A1 Lamole / MvSl-1064) (Anther smut fungus)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Basidiomycota> Pucciniomycotina> Microbotryomycetes> Microbotryales> Microbotryaceae> Microbotryum.
Aromaticity0.04
Grand average of hydropathy-0.296
Instability index49.06
Isoelectric point5.43
Molecular weight68715.64
Publications
PubMed=26076695

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU364140
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP32985
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     195.90|      36|      36|     153|     188|       1
---------------------------------------------------------------------------
  153-  188 (60.49/31.73)	PLPQQT................................LTIVPSAPPIPLPSSENDDST.NEHTGASTS
  191-  225 (50.49/25.24)	PLATSL................................ASLRESANSFFSASSQVLAST.SNST.TSTS
  460-  495 (47.32/23.18)	PTVSAF................................LSYLYRLNSL.CGVLTTLTSTiDPSIPTSTT
  504-  566 (37.60/16.87)	PLS...avrkilsppttsnelkelggrivlrigssptsLFHISHSTLLPQPSST..STT.NPSTSPSPS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      94.99|      27|      27|     305|     331|       2
---------------------------------------------------------------------------
  305-  330 (39.09/24.29)	........................GREGLGKGVGRKTGRKLVVEVEMEGR
  331-  358 (37.84/23.28)	G......................rDWCVWTSGAAEKEGKEQGVEDMLKQR
  359-  401 (18.05/ 7.26)	GrnvfaeelfavlsnearsdvsvkSRLELGK...RSQGDSVIT....EGH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      82.95|      26|     330|     264|     298|       3
---------------------------------------------------------------------------
  264-  298 (40.34/49.17)	GQGETRLAKQVG.VFYGCAeaapsfrraGVAQVEQV
  596-  622 (42.61/29.94)	GQLKGFLQEQIGeVLKGCA.........GKEEVEEV
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP32985 with Med17 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) QLTSQRIRDEQNKDLTKTSSTDEHSGEQDEHKDDVHELGITPEQMSELRMTMMRQLE
2) TVDAEALPLPQQTLTIVPSAPPIPLPSSENDDSTNEHTGAST
66
146
122
187










Molecular Recognition Features






MoRF SequenceStartStop




1) RLLRIWQE
53
60