<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP32980

Description Mediator of RNA polymerase II transcription subunit 5
SequenceMAGLAHKNLGLITRACWVKGVPPSSWQQLMAQTASSSLPPVEVEQQICDALLQLLADSTSMPSPLVLDYVQSAVTPSTSVAQFAPSLVRVGFFAARLTRCSVNSIALDKAFDVINKTLLTAASDTPTYAVLNADELVDALDWALGRISRLGTADSTPGELTPQSPTVSYISTFLQRSLIPFNLAGIDPQRLGATLASLDACVSTLQQMHVDPTAARISTDLQRTLLEIKIALSPKGEVTSKLPVVPRARIASPAPTNSLDLVPTTQADSDIAFLIWDLSYRGHTSVGIANTPVATARIVALLKDRLAQADARGSTHEQTLSRAFLELFLAATVDLRENVGKFTRQASFAYSRLPELLRNIAANRKVDVPGSPDLVRSAFDSSVRLFSVSTRTESEDAMALDGATTRPVLDALVAGLCQHELISTDLAASLSPSLHPSQLVPSSFPSTTAQLMSGSIDSVREVFASLETHGSASHRAISNSLVEAVSSLASSVDIPGLSNICSVLVEQPSILSIVFLHVQPFLVLSPIRSLLDTFGSSLENLGYDDPSTGYGVVLLFLQVVVSRHGLQTDLSHHLGSRRGFLVQWLLSISATYSLTSLDDDARATVNGWIQALFGDGISDELMHQTNPRTLLKVLPTVAKQSLAACHAGVIDTEQLRDGLSFLLQGLLSFTLPGVLKWLVGEIERTPTGDYQIMMLDILSVLIFSESLPKTIVELVASDLATLVHRLPSTTSTTIDVKRVRSLIQPYRKAVVGAKAYATPTPSSEIAAPFDLSFDRTIYSSSSTIMLYTLLNSSPPSSSLIDEMGMTRLAKTILLVPSHSTDLVDAYAARFTSFILQDLPSMSIDLPNATKLGSWIGEALKAYELIENELVHEGQSSGGVFVLLVASVVKDVKRRRALKLGDDKAVEIWAQALTAKCRRFGEGLEKV
Length926
PositionTail
OrganismMicrobotryum lychnidis-dioicae (strain p1A1 Lamole / MvSl-1064) (Anther smut fungus)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Basidiomycota> Pucciniomycotina> Microbotryomycetes> Microbotryales> Microbotryaceae> Microbotryum.
Aromaticity0.06
Grand average of hydropathy0.190
Instability index47.15
Isoelectric point5.64
Molecular weight99529.87
Publications
PubMed=26076695

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP32980
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     166.54|      52|      54|     388|     441|       1
---------------------------------------------------------------------------
  371-  403 (33.14/24.81)	....................SPDLVRSAFDS..SVRLFSVSTrtESEDAMALDGA
  404-  455 (88.51/63.19)	TTRPVLDAL.VAGLCQHELISTDLAASLSPSLHPSQLVPSSF..PSTTAQLMSGS
  458-  495 (44.89/26.92)	SVREVFASLeTHGSASHRAISNSLVEAVS.SLASSVDIP................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     103.75|      32|      54|     537|     573|       2
---------------------------------------------------------------------------
  537-  573 (47.43/43.54)	SLENLGYDDPSTGYGvvllFLQVVVSrHGLQTDLSHH
  593-  624 (56.32/36.49)	SLTSLDDDARATVNG....WIQALFG.DGISDELMHQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      67.46|      21|     171|     660|     681|       3
---------------------------------------------------------------------------
  660-  681 (36.33/23.12)	SFLLQGL..LSFTLPGVLK...WlVGE
  832-  857 (31.12/15.30)	SFILQDLpsMSIDLPNATKlgsW.IGE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      62.08|      19|      45|     170|     189|       5
---------------------------------------------------------------------------
  170-  189 (30.12/19.08)	ISTFLQRSLIPFNLAgIDPQ
  217-  235 (31.96/15.83)	ISTDLQRTLLEIKIA.LSPK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      91.61|      30|      54|     273|     304|       6
---------------------------------------------------------------------------
  273-  304 (46.72/36.13)	FLIWDLSYRGHtsVG..IANTPVATARIVALLKD
  328-  359 (44.89/28.25)	FLAATVDLREN..VGkfTRQASFAYSRLPELLRN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.71|      12|     168|      74|      85|       7
---------------------------------------------------------------------------
   74-   85 (21.78/11.48)	VTPSTSVAQFAP
  244-  255 (21.92/11.60)	VVPRARIASPAP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP32980 with Med5 domain of Kingdom Fungi
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