<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP32975

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMDPVVSSNGGGPSLQDHGHGHRPSSNLAGYSSLSSSSSPSLSLSSSAQPLPSPPQGTDCTHTAATIPSPKLNHASSQSQPVPDHEPRSLDELPTVTHDLIPLSHIVQRLVAQVHADLLNLTETLPSSSDPARKRAIVDYVLQTRRQLLKLLVLVRWSSQADALHKCMNIIGFLARQNFEFDQSVQRLHEVKDVLAGARVRNYDLTSALTVLSTGHYPFLPSVIPEFFTQPLPLSDSTVLETLAEVDQILAYRLACLENLPRAMRTYWIKDGRVAFRVERLWEATFTYGGERGKEEWYLLGIKYGFNVQDARGVWSSEPSGPIKETILQLCNQELARHPPTDPSSSSTPESAPLIRAYNFLQRLALSYQLEAIASQASVLAQTKWMGHLRCVREFDGRGLRVDYWLPKEGSNSTSANSGSGSAAAGGGAKTIPTATTPCLRFAYGQRDEVRGTERVELMRRRALDKLLIGGGTRGKRKEATTTGSQGPGSEPRQDETTEEQEDVDDALSITWTVPNSSDSAMPVDTTSVDLTLNESLDLEILLRRVTTRHVRSNMLELYDQLVHELDPKDLELVSSTNSNAPLIVDREEELQDEGVQQIKVHLYSSHYILVSLSTLSGKLEFKAVGEATSLREARLRGAAEKVDHSRRLLGETLLRIRATTILDEVDSKAGYLGLATTKRLPLKSNDLARFGSTTRGLLFIQLKGVSNGSSTGAQTASSFGWMSSGSSYYLVLVMNESGFRFALIGTREEADQMSAWTTIDEMGWIERGSMTGAGQQDPGTGFDVGIEDLRDLYAYCMKRIRFYIIESQLHLRRIPFQHVSPSAPASAPRTASLTPTSPYLVIHSSDLIVSPTPIAHRNIAIHLLPPRSHSAHSNLGDAPQDQVVFLLKLKATLSPPPQNLSLATTHADPPTPNLLPSNVLYSPPTNLLEFRFDDLETCVQDFLDAYALVVKSVVMKRHRLLEIKRQDQAVSLVKAVMEAKLGGGGELASTTGTA
Length994
PositionTail
OrganismMicrobotryum lychnidis-dioicae (strain p1A1 Lamole / MvSl-1064) (Anther smut fungus)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Basidiomycota> Pucciniomycotina> Microbotryomycetes> Microbotryales> Microbotryaceae> Microbotryum.
Aromaticity0.06
Grand average of hydropathy-0.293
Instability index51.61
Isoelectric point6.19
Molecular weight109035.94
Publications
PubMed=26076695

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU365082
GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP32975
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     118.50|      36|     297|     397|     448|       1
---------------------------------------------------------------------------
  412-  447 (63.50/59.70)	STSANSGS..GSAAAGGGAKTIPTATTPCLRFA.YGQRD
  710-  748 (55.00/25.54)	STGAQTASsfGWMSSGSSYYLVLVMNESGFRFAlIGTRE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      67.59|      20|      29|      39|      58|       2
---------------------------------------------------------------------------
   39-   58 (38.43/19.20)	PSLSL...SSSAQPLPS.PPQGTD
   67-   90 (29.16/12.81)	PSPKLnhaSSQSQPVPDhEPRSLD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     106.19|      28|      29|     870|     898|       4
---------------------------------------------------------------------------
  855-  867 (21.01/ 7.99)	.AHRNIA.......IHLL........PPR
  870-  898 (46.06/31.02)	SAHSNLGDAPQDQvVFLLKLKATLSPPPQ
  901-  924 (39.12/21.47)	SLATTHADPPTPN...LLPSNVLYSPP..
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     192.90|      66|     504|     244|     348|       6
---------------------------------------------------------------------------
  244-  313 (110.37/67.08)	EVDQILAY.....RLACLENL.PRAMR.TYWI.KDGRvafRVERlWEATFTYGGERGKEEWYLLGIKYGFNVQDARGV
  374-  409 (12.07/37.47)	SQASVLAQtkwmgHLRCVREFdGRGLRvDYWLpKEG..........................................
  461-  509 (70.46/30.87)	.......................RALD.KLLI.GGGT...RGKR.KEATTTGSQGPGSEPRQDETTEEQEDVDDALSI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      38.07|      17|      22|     625|     643|       7
---------------------------------------------------------------------------
  633-  655 (21.70/12.14)	ARLRGAAEKVDhsrrllGE.TLLR
  656-  679 (16.37/ 7.99)	IRATTILDEVDskagylGLaTTKR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     111.41|      33|     226|     322|     354|      10
---------------------------------------------------------------------------
  322-  354 (59.07/33.83)	IKETILQLCNQELARHPPTDPS.SSSTPESAPLI
  550-  583 (52.34/29.14)	VRSNMLELYDQLVHELDPKDLElVSSTNSNAPLI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.80|      16|      25|     935|     953|      13
---------------------------------------------------------------------------
  935-  953 (19.29/25.29)	LETCVQDflDAYALvVKSV
  961-  976 (26.52/18.22)	LEIKRQD..QAVSL.VKAV
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP32975 with Med14 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) GGGTRGKRKEATTTGSQGPGSEPRQDETTEEQEDVDDALSITWTVPNSSDSAMPVDTTSV
2) MDPVVSSNGGGPSLQDHGHGHRPSSNLAGYSSLSSSSSPSLSLSSSAQPLPSPPQGTDCTHTAATIPSPKLNHASSQSQPVPDHEPRSLDELPT
469
1
528
94










Molecular Recognition Features






MoRF SequenceStartStop




NANANA