<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP32972

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMAPHPLPARPIQSVAGAATPSWPSLAQPPLSTGATIHQQAARNQAGTTGFSTTLPPPPSAVQPIPRLPMPPPPYSGPASAAAQQSLGQVYSQSQSQGQSGPLPLPALGAARSSSFQGNATSPNGSNTPGSLPASPKWGTSGQHLPQSHQQHHLATPTHTPNPASSSTLSFALPRAPSMRKALTSQDVRVNSVQVDLPGQGRWKVHWRAWRGPALLDTSVAAPPTPSSTTNVSDKALAPHLGMPLHEHTPTAKYDPLASTAPTPTTTLKRARSALGDDDPSTSIPVASTSSAPGLSLRARLQGLQKVDPSQDPIELALKQVQRVAANLTASASNTVSSAVPSLFSYVRISAVRPIEDFKGKGKEKATDAQDAAVGRMLWVFGLSSDSIEHDPTREALSALEFADLICVGKGHFAHRDVFPAMYEMTTSPSTSDAKTAPSQPASVALPLALPASAFPSVLSLSAQFYADLPCPASAPQPQTRICSPCEAFLAGFGSVIRQSLLAQEDGHSSSELRRPALPLGSAIVILPPASEPFGYSGRRISPEAIKTTLHLSLNLQGLLVRSAVEDVAYRPYPVLSASVTPVPTGAPVLLAPLGTPATFIRTVASSSHSLHTSRVDASLRQTWLNALGGLDLALDEHEHWLVCRILIPPHGTTANMSPQVSVSSPEHLDVMWPASLCLLDGTRSQPLRSPQSTPPRPKAVDLVDSLSLDPFVRTTFETGLSSPDVLTRQQLAAALHRGLAADAVNPHKSSSSTTYHDPIRARVEQVGTLFVELQEQREQRLRLDREAEAVRASTVAAATTAPPASPPVAEPGKLNSTAAPISMRTPISLVGGSTEALSPGDAFSAAERSLMSALGEAPFASTDPATMQASNASALTTIKNAEMDHLYPSPFEAPNALPIVSEGVGSDSVMNTVELGSSHDATFPNFDWGEDFSAGQNPGLRHNQDFDDGMMMDLNDDDFSFFDDPAPLPTSLPLGTLAGLQSPGPSPKFLDHFSHLGSGATPFPSVASPASPSLGIASPNVHTSPAVLSFSFDNSQSHNALGLGGTTPRAQLAEQSPFKTPRTPYTPYVEVVDEENEPESAHSGTHATATVSVAGTPASTALALKKLTQFEAVPFGSSHAKADDRYDPRKGKFGLPSPGWDHKELPMGNMSNALASGVPWLTAMCDPRANAARQLKQKRTPSLAKKRPGTDGTSYPCARVQTRDRKWIRFTEVDSDNPGEEDSEDDDMDGPVEPQHHGGDDLVATETGPSHRAPENFFGSGLLILRDHLNRMLSTTGAKVDIIAPVPVATKATKAAEHALETTVGLMADQTLHNPDFRNRSAALKVRSKSSGAKASSIATRIVYNLLTRVAPNPDPLPLSTLHAPTLLLRAQQTIMQLSTSALDFWNPMGFEPLSGPKDVTAFAVFEELNTDTREAVASWLDDVSEGYQSSRLGRHELGHIAASGTFSGVENGLAALPVGALSRVRDDYKGMANHLVDAARTRKHVVIYLLDPSEASRTSASAAPSIIAALAHILKSRASTMSLVVYPLPLSTVSRWRSIASADSIAARLRRLAFAVYDTLLVSVSSLPAPVPETFPSSQIGRHPVLGPLTRLYQSPAITASPVRETSIEFALVWPPSSLEVLHRHRLLHVAYGCFRAPAEGERGPALEWIVISGIDEKGETWKSVPQIVRYPPQMQLEEARARQVWKAAKSLHDTADIEWRVVVTKLGNMSKEEIIAWDKISRDIISALRRPLHITISCAEIGPALSMLPVLHEASEHTSSPMSEEGELGAGNDAGTTMSPALGRSHAGRTRNQSKPIHLDSGTCLFVHTPNHPITFDTSASLVAPASSFLIHAPRLPTFAQAPFQPFMPASPAISVLALHVLSSACTKTSTLRIDLSQHVADIMQSFADLAALGHARWGASGRVPWHLEAVASVLDILAALT
Length1924
PositionKinase
OrganismMicrobotryum lychnidis-dioicae (strain p1A1 Lamole / MvSl-1064) (Anther smut fungus)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Basidiomycota> Pucciniomycotina> Microbotryomycetes> Microbotryales> Microbotryaceae> Microbotryum.
Aromaticity0.05
Grand average of hydropathy-0.207
Instability index54.38
Isoelectric point6.37
Molecular weight204232.97
Publications
PubMed=26076695

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
ECO:0000256	RuleBase:RU364134
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP32972
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             7|    1152.77|     173|     174|     428|     600|       1
---------------------------------------------------------------------------
   10-  210 (136.77/39.99)	...................................................................PI.....QS..V.AGAAtPS....WPSL..A.QPPLSTGATIHQQAARNQ...AgttGFSTTLPPPPSAV........Q...PIPRLPMPPPPY.SGpasaaaqqsLGQVYSQS...QSQGQ.SGPLPLPALgaarsssfqgnatsPNGSNTPGS.LPAS...........PK.WGTSG.......................................QH...L.P.....QshqqhhlatpthtpnpAS........................................S..........STLsfalprapsmrkaltsqdvrvnsvQVDLPGQG...RWKVHWRAWR
  211-  394 (163.54/49.14)	GPALLD.TSVAapPTPSSttnvsdkalAPH.LGMPLheHT.PTAKY..............dplastaPT....pTT..T.LKRA.RSalgdDDPS..T.SIPVASTSSA.PG.LSLR...A...RL........QGL........QkvdPSQ...DPIELALKQ.........VQRVA.ANLTASASNTVSSAV..PSL..............FSYVRISAV.RPI............ED.FKGKG.......................................KE...KAT.....D................AQ........................................D..........AAV........................GRMLWVFGLSSDSIEHDPTRE
  395-  570 (250.87/78.98)	ALSALEfADLI..CVGKG.........H....FAHR..DVfPAMYE.................mttsPS.....TS..D.AKTA.PS....QPAS..V.ALPLALPASAFPSVLSLS...A...QFYADLPCPASAP........Q...PQTRICSPCEAFLAG.........FGSVIRQSLLAQEDGHSSSELRRPAL..............PLGSAIVIL.PPAS...........EP.FGYSG.......................................RR...ISP.....E................AI........................................K..........TTL........................HLSLNLQGLLVRSAVEDVAYR
  571-  737 (158.18/47.31)	PYPVLS.ASVT..PVPTG.........APV.LLAPL..GT.PATFI.................rtvaSSshslhTSrvD.ASLR.QT....WLNA..LgGLDLALDEHEHW..................LVCRILIPphgttanmS...PQVSVSSP.EHL..............DVMWPASLCLLDGTRSQPLRSPQ..................ST.....PPRPkavdlvdslslDP.F..........................................................................V........................................R..........TTF........................ETGLSSPDVLTRQQLAAALHR
  746-  962 (157.12/46.95)	PHKSSS.STTY..HDPIR.........ARV...EQV..GT...LFVelqeqreqrlrldreaeavraST.....VA..A.ATTA.P......PASppV.AEPGKLNSTAAP................ISMRTPISLV........G...GSTEALSPGDAFSAA.........ERSLM..SALGEAPFASTDPATMQA...............SNASALTTI.KNAE...........MD.HLYPS.......................................PF...EAP.....N................ALpivsegvgsdsvmntvelgsshdatfpnfdwgedfsagqnP..........GLR........................HNQDFDDGMMMDLNDDDFSFF
  963- 1158 (104.27/28.89)	DDP.......A..PLPTS.........LPLgTLAGL..QS.PGPSPkfldhfshlgsgatpfpsvasPA.....S..........PS......LG..I.ASP.NVHTS..PAVLSFSfdnS...QSHNALGLGGTTP........R...AQ...............................LAEQ.....SPFKTPRT..............PYTPYVEVV.DEEN...........EPeSAHSGthatatvsvagtpastalalkkltqfeavpfgsshakadDR...YDP.....R................KG........................................KfglpspgwdhKEL........................PMG.NMSNALA.SGV......
 1159- 1318 (182.02/55.45)	..PWLT.AMCD..P.RAN.........AAR.QLKQK..RT.PS....................................lAKKR.PG....TDGT....SYPCARVQTRDRKWIRFT...E......VDSDNPGEED........S...EDDDMDGPVEPQHHG..........G....DDLVATETGPSH...RAPEN..............FFGSGLLILrDHLN...........RM.LSTTG.......................................AKvdiIAPvpvatK................AT........................................K..........AAE........................HALETTVGLMADQTLHNPDFR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     294.00|      96|     147|    1339|    1439|       2
---------------------------------------------------------------------------
 1339- 1439 (158.74/108.32)	ATR....IVYNLL.....TRVAPNPDPLPLSTLhAPTLLLRAQQ...TIMQLSTSALDFWNPM.GFEPLSGPKDVTAFAVFEELNTdtreAVASWLDDVSEGYQSSRLGRHE.LG
 1479- 1588 (135.26/79.93)	AARtrkhVVIYLLdpseaSRTSASAAPSIIAAL.AHILKSRASTmslVVYPLPLSTVSRWRSIaSADSIAARLRRLAFAVYDTLLV....SVSSLPAPVPETFPSSQIGRHPvLG
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP32972 with Med13 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) ALLDTSVAAPPTPSSTTNVSDKALAPHLGMPLHEHTPTAKYDPLASTAPTPTTTLKRARSALGDDDPSTSIPVASTSSA
2) GSSHAKADDRYDPRKGKFGLPSPGWDHKELPMGNMSNA
3) HEASEHTSSPMSEEGELGAGNDAGTTMSPALGRSHAGRTRNQS
4) HNALGLGGTTPRAQLAEQSPFKTPRTPYTPYVEVVDEENEPESAHSGTHATATVSVAG
5) KWIRFTEVDSDNPGEEDSEDDDMDGPVEPQHHGGDDLVATETGPSHRA
6) MAPHPLPARPIQSVAGAATPSWPSLAQPPLSTGATIHQQAARNQAGTTGFSTTLPPPPSAVQPIPRLPMPPPPYSGPASAAAQQSLGQVYSQSQSQGQSGPLPLPALGAARSSSFQGNATSPNGSNTPGSLPASPKWGTSGQHLPQSHQQHHLATPTHTPNPASSSTLSFALPRAPSMRKALTSQDVRVNSVQVDLP
7) QEQREQRLRLDREAEAVRASTVAAATTAPPASPPVAEPGKLNSTAAPISMRTPISLVGGSTEA
8) SGVPWLTAMCDPRANAARQLKQKRTPSLAKKRPGTDGTSYPCA
213
1116
1754
1038
1206
1
774
1156
291
1153
1796
1095
1253
197
836
1198










Molecular Recognition Features






MoRF SequenceStartStop




1) RWKVHWRAWR
201
210