<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP32956

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMAPLPLEGLQNPVANTIGQGAMSGPQEGNRGGMMSLAMLIDFIIQRTYHELTVLAELLPRKTDMERKIEIYNFSTRTRQLFVRLLALVKWANSASKVEKSARIMGFLDKQSLLFVETADMLARMARETLVQARLPNFHIPAAVEVLTTGTYGRLPACIKEKIVPPDPITPQEKKMTLLRLNQVIQHRLVTGNLMSQMRNLKIENGRVTFTVQHEFEVALTVMGDGPTIPWRLLEINILVEDKETGDGKALVHPLQVQYIHQLIQARLVDNPQPLAEVYNCLHFFCQSLQLEVLYSQTLRLMRDRLDDHIHVDEYIPGRSLTVSYWRDLRSEIGYKLTVQVDQHDPARPLAVLHVPSLGNKESEIADRAIRSEVLSMERLLVHTIYMRTRSRLDDIQLELQELIKNAECLVQGSPAVLNVAILQPCLRAEQVLITIDTHTGMIQCHVPLYDPPIVPEINNILNGNRAKLLPYISELRYWITKRRCEQTLQHLPASAHERLPLLHAPDHPITKIGKHNMYIQFHRHTNVILIVEFKEKESNPCIVDCSFHLCVVKHSSIEDNPKDDSIETEIPKVFLKVQTLIEFDTFVATHGPFTAIDGDSDDQAEAHPLKRKGEMVIESATKRNKQPAYFIPELAHVVAMCDERLPYVTLASELTRRDIFHQGLQVEANATGLVLKLIQLPPPTSEIGGSAAWFALLKRLLSVSIRVVGKNNAKSWLVEFVFYASPLTSSHAKEQGSRRPIYFQYEMLSADQTSKTVENLLNDWWKIVQLYTLVHDLSEYLKMDKFSFFCNMFSIRCYNYAKLVICYGPDKGAMVSLVWDCKSNLFKLTFGAMQNSLNAHSLIQEQLESHLNEFRNLAQIIQLLTETYEPLVSLSKLPTLPQLGVHNVNHKVPVQTFTIMAQSCILIRLTFQGMYCLELKIRGGGLVSIRDGAYSLFDMCNVLSVFFPTPGLKTFLSKYIDENAVFRRRSQSEDDNPPSPVEIDGGNFLGSHRPPQSPAGGSRSEPGLRFHPPLTPPSGSNPHTPASPHTANMSQTTHNGFGSSPATSFNLASPTSLSSNINPSPMPHPSPSGLVPNSPLNPQLASPGGLLSNSSPGPQQGGTTNIPGHSPVGSYIPSNHTDGSPFPASQSPAASNWPGSPGMPRPSPVRPGQSPGGPVLHSPQQMDLKSGNHLARVLPPRSWAGAVPTLLTHEALETLCCPSPHPLGIPGPEMSPLERFLGCVCMRKQLQRFVHNENYLTIISTQEPGVIHFKVNDILQCRVGLNTQHLQSLHIKISQLAEHKEIWSPEELQVLERFFETRAAAPPYKPTSMFTFCSMLNSPPNVLKDFIQIMRLDMMPHLAQQQGMKWSVQWLLRIPPNALPIVPTGTQGVLAIRNKILFFIQITRLGYPANADPPSIVLPLIYDIAGNITQLAEKRDIGSPPAMTAAGQVLRHFCQMQAGTVECTVYPALREILMNLTFPSDPQQPSPQQGGVQQIQSPAMSMPGQGGNPGYPPHMQVGMMGPQ
Length1507
PositionTail
OrganismDendroctonus ponderosae (Mountain pine beetle)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Coleoptera> Polyphaga> Cucujiformia> Curculionidae> Scolytinae> Dendroctonus.
Aromaticity0.07
Grand average of hydropathy-0.187
Instability index56.39
Isoelectric point7.47
Molecular weight167985.00
Publications
PubMed=23537049

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU365082
GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP32956
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     606.67|     173|     327|      56|     240|       1
---------------------------------------------------------------------------
   56-  226 (245.66/168.34)	................ELLPRKTDMERkiEIYnFSTRTR..QL......................FVRLLALVKwaNSASKVEKSARIMGFLDKQSLLFVEtaDMLARMARET.LVQARLPNFHIPAAVEV..LTTG.......................TYGRLPACIKEKI....VPPDPITPQEKKMTLLRLNQVIQ.HRLVTGN..LMSQMRNLKIENG.RVTFTV.QHEFEVALTVMGDGP
  227-  355 (134.65/84.12)	TIPWRLLEI..................................nilvedketgdgkalvhplqvqYIHQL.............................................IQARLVDNPQPLA.EV..YNCL.......................HF....FCQSLQL.......EVLYSQTLRLMRDRLDDHIHvDEYIPGRslTVSYWRDLRSEIGyKLTVQVdQHDPARPLAVL.HVP
  356-  561 (226.36/136.53)	SLGNKESEIadrairsEVLSMERLLVH..TIY.MRTRSRldDI......................QLELQELIK..NAECLVQGSPAVLNVAILQPCLRAE..QVLITIDTHTgMIQCHVPLYDPPIVPEInnILNGnrakllpyiselrywitkrrceqTLQHLPASAHERLpllhAPDHPITKIGKH......NMYIQfHRHTNVI..LIVEFKE.KESNP.CIVDCS.FHLCVVKHSSIEDNP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     299.70|      49|      51|     977|    1025|       2
---------------------------------------------------------------------------
  977- 1019 (76.84/29.38)	...............................PPSPVE.........IDGGNFLGSHRP.PQSPAGGSRSEPGLRFHPPLTPPSG
 1020- 1089 (66.79/24.61)	SNPHTPasphtanmsqtthngfgsspatsfnLASPTS.........L.SSNINPSPMP.HPSPSGLVPNSP...LNPQLASPGG
 1092- 1117 (41.59/12.65)	SN.SSP....................................................gPQQ..GGTTNIPG...HSPVGSYIP
 1118- 1152 (56.59/19.77)	SN.HTD.......................gsP...................FPASQSP.AASNWPGS...PGMPRPSPVRP..G
 1153- 1201 (57.90/20.39)	QSPGGP...............................vlhspqqmdLKSGNHLARVLP.PRSWAG...AVPTLLTHEALETLCC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     215.06|      54|      56|    1379|    1432|       3
---------------------------------------------------------------------------
 1325- 1375 (55.91/26.52)	NVLKdFIQIMRLD.....mMPHLAQQQGMkwSVQWLL..RIPPN..AL.PIVPTGTQGVLA....
 1379- 1432 (94.10/49.85)	KILF.FIQITRLG......YPANADPPSI..VLPLIY..DIAGNITQLAEKRDIGSPPAMTAAGQ
 1436- 1489 (65.05/32.10)	...H.FCQM.QAGtvectvYPALRE...I..LMNLTFpsDPQQPSPQQGGVQQIQS.PAMSMPGQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      66.02|      16|    1479|      11|      26|      15
---------------------------------------------------------------------------
   11-   26 (30.66/16.64)	NPVANTIGQGAMSGPQ
 1492- 1507 (35.36/20.39)	NPGYPPHMQVGMMGPQ
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP32956 with Med14 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) FRRRSQSEDDNPPSPVEIDGGNFLGSHRPPQSPAGGSRSEPGLRFHPPLTPPSGSNPHTPASPHTANMSQTTHNGFGSSPATSFNLASPTSLSSNINPSPMPHPSPSGLVPNSPLNPQLASPGGLLSNSSPGPQQGGTTNIPGHSPVGSYIPSNHTDGSPFPASQSPAASNWPGSPGMPRPSPVRPGQSPGGPVLHSPQQMDLKSGNHLA
2) TFPSDPQQPSPQQGGVQQIQSPAMSMPGQGGNPGYPPHMQVGMMGPQ
966
1461
1175
1507










Molecular Recognition Features






MoRF SequenceStartStop




NANANA