<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP32953

Description Uncharacterized protein (Fragment)
SequenceMFNCNLLYEKRPLKKPRIGPPDVYPQEPKQKEDELTSVNVKLGFPTMTHLNDEFGTAKNCNVTASKVGSYFNAIINRKEELSAMPDSGRKRQQINPKDNFWPATIRTKNHIEAWFKDLAGNKPLMILSKRAPNFNKKEEIFMTLTEYQVPMMRAAWFIKLSSAYTVAVSEAKIKKRQMSDPTTEWTSTLLKFLKDQIPKLQEYYCQTEKPPTNAPLAALANNETEQKLALRFWTYCCRLLKYMYEEGLIDRQDVLTWIIELLEKHEKPKNPSLDDGLLRLLLPLTLQYLEYLVLDEFVQSELLSRRLCHFCAKKLNVMMNSVAEPSLITSPPGEIKTEPKEGEKDLKKETLPVNPLQSNLAEYQNCQHHRDIVVELSTVVHTIILECPTALVWCPTGFGTQWHGSPLDTLPISPSLLPLPARCDTNSYLKQIKQAEAAIRDRSKRADGKWCTDKFQTSSAGTVTTRVLAALDALDRHRFDKMDSTNSLDTLYSKVFSGSGDQENSIVKLLCEWAVSPERTGEHRALAVAALLDRRQSDSNPSENHDAIPGDDKESCGSVPGGPPMFQSLLMKFLDIDAPLPSPDDSVQKKTAFSNLVHLFAELIRRDVFSHDAYMCTLIARGDLIGHEDNSDNMSNHHHSKIEHMDYDDADVDNDLDKILQNIKEDQQNSMDIPDSPKEHDHGHHPHVPNIGHVPIENGHGDNKIKASRHFLYTTHFPLSQDDPFCQHDCNQRHVLLYGVGKIRDEARHTVKKMSKEICKLFSKKFSVDVAEGGKVHTSILINSEMAVKKHSRNEFNFEATTQKCQSLSYFDQHVVTWQCSVTVVEMLNSFATGNSNYLPVQEHVAFLFDLMELALNIYGLIDVCIQILKELPEVEIQLHNKNSVLSRNYTTGLSLYIVVSPDQTSAVFEGLCKVVKHVTNPGDCSSAERCILAHLYDLYSSCILLKSKPHAVEPFGNAYPKIKQALYSSLVLQPTSSTYVFNSQFMQEVFKNPRRIGRIESTWAKQLNESPSNRYSFVSNAIIRACCKEPETDRINDNERLNDLAILCAEMTACCNSLASEWLGVLLGLCSPTSPPEYYKDVLNEIKIEDVNIHNSLAVFTCILIARHCFSLEDFVRTVALPSLLKVKSLDSSSGLAEAGMRLTCHLLLRLFRTAEGPQPGLYSVGSPPLSSPRVPLGVRLSCDRHLLAAAHRNIDVGPVLAVLKAVLIVGDATAKQGTEPSLSNILGTSDLHSGLDGPSLDLPQISTGNPEATASLSAFANHVLREICSQQWVLDRCLCHPEKLCDSDNLLDDLLTHSQAQRLLHMICYPELASSIDELDQKNMISRILENYRIVFVNTNLLQNLELWTLRMSWLDLQLMFKQYSVNTPELSQWLDTVAKAAIDVFQLNAPSINHTRSEDTKKQEPRSKTSSIWLVAPLIAKLSGAIQGRVLKPFLSLVLTCLKGQEEGQKEGLLSSLHQQLTQLVQQAKEGNLQDTCHSDRTLDGLQLRFALVGGVFEAFQRNSSATTDWALLLVQLVTHGIIDLHTNNELFTTVIDMLATLVHSALATDTQDDGKKMHQNLMKKIKKEIGERQNVSLMHIKQLLPLPRVTTEIIGVEPTGCLTDSKGYKISFDSVDKKHDLSISDKQRVSSWDILEGMKNPPPLSWAWFGAVRLERKPLMGEDTHRLLKFHTHNLQKPSMYYLDPPPLPPEDLEPIADKPDSNLKADTPSSVDQSPVALGKGRGKGQRKRKPKSGPVTMSPMTMGHNPIGQGPPGMGIGVQGNNPQMPHGLGAYGPNPGMQPGQQYGTNPGQQWYGQNQSAQQPYGYPPMSGSRFDRPPLNTSKQALSNMLRQRHPINNYGMPGIPNNPAAGGPAPGYGHMQRFSRQTLRQQHPGNMQSNQAIFPNQYGNMQPGMSNQYGNFGGNTQMPQGSMQSNPQIMQASQANMFGGQQQGFGQPRPAQPDFRQMAGNPRAPYLQQAPNVTMNTNMGAMGGMGSQGGPAPPYSRPGQVMQQSVQSQQTPFQQQRMRQQIMALQQQQGGPGGNQPNPALVAHLQRQQMNPQGYHQPPPYNMHFTETDNFQ
Length2066
PositionKinase
OrganismDendroctonus ponderosae (Mountain pine beetle)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Coleoptera> Polyphaga> Cucujiformia> Curculionidae> Scolytinae> Dendroctonus.
Aromaticity0.07
Grand average of hydropathy-0.458
Instability index45.81
Isoelectric point6.84
Molecular weight230934.61
Publications
PubMed=23537049

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP32953
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             8|     359.82|      37|      37|    1860|    1896|       1
---------------------------------------------------------------------------
 1726- 1757 (41.86/19.61)	.G...RGK....GQ.R.KR...........KP..KSGP...VTM.SP....MTMGH.NP..IGQGP
 1758- 1793 (47.51/23.47)	PG...MG.........IGV...........QGNNPQMPhglGAYGPN....PGMQPgQQ..YGT.N
 1794- 1811 (24.76/ 7.92)	PGqqwYGQ..................................N.QSA....QQ..P.....YG..Y
 1815- 1859 (37.67/16.74)	SG...........S.RFDRpplntskqalsNMLRQRHP...INNYGM....PGI.P.NNpaAGGPA
 1860- 1896 (75.84/42.83)	PG...YGH....MQ.RFSR...........QTLRQQHP...GNMQSN....QAIFP.NQ..YGNMQ
 1897- 1936 (44.21/21.21)	PG...MSN....QYgNFGG...........NT...QMP..qGSMQSNpqimQASQA.NM..FGGQQ
 1937- 1968 (47.14/23.21)	QG...FGQ.....P.RPAQ...........PDFRQM.A...GN...P....RAPYL.QQ..APNVT
 1977- 2015 (40.82/18.90)	GG...MGSqggpAP.PYSR.........pgQVMQQ.......SVQSQ....QTPFQ.QQ..RMRQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     164.78|      37|      38|    1123|    1159|       2
---------------------------------------------------------------------------
 1087- 1121 (24.65/10.66)	...IKI.EDVNIHNSLA....VFTC..ILIARhcfsledFVRTVA...
 1123- 1159 (64.20/41.44)	PSLLKV.KSLDSSSGLAEAGMRLTC..HLLLR.......LFRTAE.GP
 1161- 1200 (55.84/34.94)	PGLYSV.GSPPLSSPRVPLGVRLSCdrHLLAA.......AHRNIDvGP
 1222- 1242 (20.10/ 7.13)	PSLSNIlGTSDLHSGL..DGPSL.........................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     125.28|      26|      26|    1271|    1296|       3
---------------------------------------------------------------------------
  295-  309 (17.06/ 7.22)	DEF...VQSELLSRRLCH...........
 1271- 1293 (39.12/29.02)	......SQQWVLDRCLCHPEKLCDSDNLL
 1294- 1318 (29.86/19.88)	DDLlthSQAQRLLHMICYPE.LASS...I
 1319- 1344 (39.25/29.15)	DEL...DQKNMISRILENYRIVFVNTNLL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      61.07|      15|      18|    2019|    2033|       4
---------------------------------------------------------------------------
 2019- 2033 (32.16/17.09)	LQQQQGGPGG.NQPNP
 2039- 2054 (28.91/14.49)	LQRQQMNPQGyHQPPP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      81.28|      23|      26|    1658|    1680|       5
---------------------------------------------------------------------------
 1658- 1680 (40.19/23.52)	LERKPLMGEDTHRLLKFHTHNLQ
 1687- 1709 (41.09/24.24)	LDPPPLPPEDLEPIADKPDSNLK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.14|      15|      16|     598|     612|       7
---------------------------------------------------------------------------
  598-  612 (25.04/19.69)	HLFAELIRRDVFSHD
  614-  628 (25.10/19.77)	YMCTLIARGDLIGHE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.04|      12|      58|     393|     404|       8
---------------------------------------------------------------------------
  393-  404 (29.26/16.15)	WCPTGFGTQWHG
  450-  461 (24.78/12.58)	WCTDKFQTSSAG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.12|      16|     205|    1051|    1071|      14
---------------------------------------------------------------------------
 1026- 1049 (25.33/15.41)	ACCkepetdriND..NERLNDLAILC
 1054- 1071 (28.80/19.83)	ACC........NSlaSEWLGVLLGLC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.06|      14|      17|     893|     906|      15
---------------------------------------------------------------------------
  893-  906 (24.09/17.60)	GLSLYI..VVSPDQTS
  911-  926 (21.97/15.22)	GLCKVVkhVTNPGDCS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      33.36|       9|    1151|     416|     425|      16
---------------------------------------------------------------------------
  416-  425 (15.36/12.37)	LLPLPaRCDT
 1587- 1595 (18.00/ 9.17)	LLPLP.RVTT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      65.36|      21|      22|    1511|    1532|      17
---------------------------------------------------------------------------
 1511- 1532 (31.79/31.09)	TDWALLLVQLVtHGIIDLHTNN
 1536- 1556 (33.57/26.54)	TTVIDMLATLV.HSALATDTQD
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP32953 with Med12 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) ALLDRRQSDSNPSENHDAIPGDDKESCGSVPG
2) LDKILQNIKEDQQNSMDIPDSPKEHDHGHHPHVPNIGHVPIENGH
3) PSMYYLDPPPLPPEDLEPIADKPDSNLKADTPSSVDQSPVALGKGRGKGQRKRKPKSGPVTMSPMTMGHNPIGQGPPGMGIGVQGNNPQMPHGLGAYGPNPGMQPGQQYGTNPGQQWYGQNQSAQQPYGYPPMSGSRFDRPPLNTSKQALSNMLRQRHPINNYGMPGIPNNPAAGGPAPGYGHMQRFSRQTLRQQHPGNMQSNQAIFPNQYGNMQPGMSNQYGNFGGNTQMPQGSMQSNPQIMQASQANMFGGQQQGFGQPRPAQPDFRQMAGNPRAPYLQQAPNVTMNTNMGAMGGMGSQGGPAPPYSRPGQVMQQSVQSQQTPFQQQRMRQQIMALQQQQGGPGGNQPNPALVAHLQRQQMNPQGYHQPPPYNMHFTETDNFQ
530
656
1682
561
700
2066










Molecular Recognition Features






MoRF SequenceStartStop




NANANA