<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP32941

Description Mediator of RNA polymerase II transcription subunit 17
SequenceMSFSSVNISVEAPIENQIQEISYDGIEIYQPPLTLSESLAKYAQKIDFSKTTDVDIKKEEAVEEAKSDSDSKDAFQSSLWPWDSVRNKLRNAHQEICVLADVLTVAKDKRYMVLDPVQREPLETKPMVQIYARKKALAGAANVLLAGAEKLKTSQNEVARNRTTPDFHIELLRLRQNWRLKKVSNMIIGDLSYRTAGSKFMQTGTFEVNSQVLNGRKIVACKPQVTKAEEDEKIGSPPSSPLPGGGQPTKPSSALKVTIPSELQGVAYIEVLCQKDTEDLCSANINLLGSGAPSSNPDMHWQQKLEAAQNVLFCKELFNQLAKEAVQLQAPIPHMVVGNQIVATILPGIQIIIALRHSTSGDKKPEKPTPSKGEHDHVLEHSLHQLLREVHHKNTHHPFPHPATGPLGPSKKRMMAGPMAADRYELLDMTKQETLLEQIIKQSQHCLMRMRTGYVLDTLAKECRDPLISSHWNTLNSPTQSCVKINISTHGYDAVCRTPLVIHVGEKSLKCICRDGKVMNLSYEPQEFRDLIFNHITQHQILAVQALAKTMGWQSLANSNHLGSGPVDPLGNATSCLLASPTGDRIIAVRCEAQYGGMQVSVAHSPRSDFFPSRLVTERKWEHLGGQFRDVRLDRMEGRNFLHKMELLMASLTSNS
Length656
PositionHead
OrganismDendroctonus ponderosae (Mountain pine beetle)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Coleoptera> Polyphaga> Cucujiformia> Curculionidae> Scolytinae> Dendroctonus.
Aromaticity0.05
Grand average of hydropathy-0.395
Instability index43.83
Isoelectric point8.28
Molecular weight73017.87
Publications
PubMed=23537049

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP32941
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     123.29|      40|      47|     418|     464|       1
---------------------------------------------------------------------------
  418-  464 (60.18/65.19)	PMAADRYELLDMTKQETLLeqiIKQSQH.....ClmrmRTGYVLDTLAKE....CR
  466-  514 (63.11/47.02)	PLISSHWNTLNSPTQSCVK...INISTHgydavC....RTPLVIHVGEKSlkciCR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      79.31|      23|      47|     537|     559|       2
---------------------------------------------------------------------------
  537-  559 (41.19/26.53)	TQHQILAVQALAKTMGWQ.SLANS
  582-  605 (38.12/24.10)	TGDRIIAVRCEAQYGGMQvSVAHS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      98.89|      29|      52|     234|     263|       5
---------------------------------------------------------------------------
  234-  263 (49.13/29.34)	IGS.PPSSPlPGGGQPTKPSSALKVTIPSEL
  288-  317 (49.77/25.90)	LGSgAPSSN.PDMHWQQKLEAAQNVLFCKEL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP32941 with Med17 domain of Kingdom Metazoa
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