<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP32933
Description |
Mediator of RNA polymerase II transcription subunit 4 |
Sequence | MLPASISVARAPHHPHQLTMYTTVQKALDNLDEHLAKVIESVSSYNPSRATVAALVQADDELQATLAELEEHQQNYHRTIELQQTSDALDDKLTDLLTILAETRQHLIDTPSTKFPTPPKEVEYNQLLQFARNISKYSKPPNPLSFEKWAREQVLPPPPPPQSEGEAKPEEPVKTKLPLGINEEDLLHMDNSGALPYAPWPHEFMMKTGALAALGKDGIPVDMIPKEDKPQEEDKGDQARKDSTSNGGMDDAEKARRSSYQQQQHAAPKPAAPKNFSLDLWPGDDDDE |
Length | 288 |
Position | Middle |
Organism | Pyronema omphalodes (strain CBS 100304) (Pyronema confluens) |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Pezizomycetes>
Pezizales> Pyronemataceae> Pyronema.
|
Aromaticity | 0.05 |
Grand average of hydropathy | -0.830 |
Instability index | 50.17 |
Isoelectric point | 4.89 |
Molecular weight | 32100.43 |
Publications | PubMed=24068976
|
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364141
|
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro
|
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro
|
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro
|
Interaction
Repeat regions
Repeats |
>MDP32933
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
3| 114.71| 28| 79| 97| 124| 1
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66- 96 (35.15/18.39) LAELEEHQQNYhrtIELQQTSDALDDKLTDL
97- 124 (45.96/26.22) LTILAETRQHL...IDTPSTKFPTPPKEVEY
125- 146 (33.60/17.27) NQLLQFARN.........ISKYSKPPNPLSF
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 53.14| 15| 184| 11| 28| 2
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11- 25 (28.89/20.95) APHHPHQLTMYTTVQ
43- 57 (24.25/ 9.16) SSYNPSRATVAALVQ
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