<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP32930
Description |
Mediator of RNA polymerase II transcription subunit 14 |
Sequence | MTAPSRTMPPQTSVALSKKEKGGSSAPIVSLEIRAPKLPQMTPSFVQLRTLVQRLVQDAFNELQMMVDSISSIGMSSEEKKSRIVKYALDTRKQFIKLLVLEAWSHDAPSVTELINIKTWLDSESTVCTRTVELLMLTRKLTSAARIRNPDLETAIEILSTGRPQTAMMKRYVPPPELTSADILKICHNLNAQLSIRLGLHENIPPYFRGYKIASGRATFTAKDEFEVDLSISDDNPKSQFYVIDVRPIYEPAIRPLPQSILKTLELQGNHVLFERGLEGIFDYLHNYFLTTKIETLHRQVSEMRWGRWTENLHITQHKRTLVIQYWPQRSGEQKSMEKSWIEVGIKRGIKGGPSRLGARWVREGQEMKDIEVPLDVANLSAEELVKTTISMHTKHILKTLQLKLYSIPLFKTPGTVTFVQHPTDSLETYLRIQLTPSKECKVLIEPITGRFAIQKPSEKAAKLEMDINNSPIARAADYVSRFRGLVLQEEVEQRARSMGWDVLKFLQLRKEELKPHFPTNTQYLLYIRRRGWLPNWVIAFVLSDTGESWWATQIEEKPLGWTISIALRIPTKGDMNVTYRFLENLEKMAAGFISLYVNHLELESRNVQHRFAPSKVVGSSYTSPIQLPDLYFRSESFIKAARGVINVLQISFQGLAEADGHCTIICMGRTNEPMTQISSTPLSTDESDVSFHPQSGSYAIRFIIRVGESIIPQVIEKLHRIECLISFVTVIRKFQLNCTHVSLGRVVFRYSDDPAHTAEISFTGEMEMKLILPEGSPHNRMKTLLQKTLNEKNQTAESNETTGLATVIKTLIATLPLMVEFNAIEYSLPKTTTVDDFSILIRGIDGFRMEYKNKKSTIDIRLQNRRSMMYWYFTDPAASGNCFLAPDGKVCAQLKEIWMGEGVGWYGLKNGAAAKLAGTRDLVRKCHELIWGKSGSQRAVE |
Length | 942 |
Position | Tail |
Organism | Pyronema omphalodes (strain CBS 100304) (Pyronema confluens) |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Pezizomycetes>
Pezizales> Pyronemataceae> Pyronema.
|
Aromaticity | 0.08 |
Grand average of hydropathy | -0.255 |
Instability index | 45.79 |
Isoelectric point | 9.14 |
Molecular weight | 107053.52 |
Publications | PubMed=24068976
|
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU365082
|
GO - Cellular Component | mediator complex GO:0016592 IEA:UniProtKB-UniRule
|
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:UniProtKB-UniRule
|
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro
|
Interaction
Repeat regions
Repeats |
>MDP32930
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 47.79| 15| 134| 261| 275| 1
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261- 275 (26.62/20.55) ILKTLELQGNHV.LFE
397- 412 (21.17/14.66) ILKTLQLKLYSIpLFK
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 42.19| 12| 33| 414| 425| 4
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414- 425 (23.71/15.70) PGTVTF.VQHPTD
447- 459 (18.48/10.56) PITGRFaIQKPSE
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 111.54| 34| 454| 219| 259| 5
---------------------------------------------------------------------------
219- 259 (51.50/64.51) TFTAKDEFEVDLsisddNPKSQFYVIdvRPIYEPAIRPLPQ
681- 714 (60.04/49.99) TPLSTDESDVSF.....HPQSGSYAI..RFIIRVGESIIPQ
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 45.59| 12| 33| 327| 338| 6
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327- 338 (23.26/14.70) WPQRSGEQKSME
361- 372 (22.33/13.81) WVREGQEMKDIE
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