<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP32924

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMDSPSNALTNVLKIDNLSRVPYATYTLAVSDDDFIGLDEDRQCDILRDAERTLRAEGVPVLSDLENNCLWVFHIAGITRVSAGAEEGEILVDDEQPADEKDERWLQIEERLSEEWSLKESSRDIFHSSSLTPPLQAPLTTPFAAITIDPMTTAPPTPKTEVIDLTLDDEPRPADPPPPETLEERNARIYRYLLTSVIGVLTFHLSLHSGFTPLNARTLVAPSSLPTLISKTTNNGKDAGGKNDPLPFSHITAPELATPLVMELNAYLTTVGTLLITPSSTKQQAIRRLGSSGYTDKSWVERECFIAPWGEWGRIIPPSESESSILPASESRWKESVTSYLKDHGIISPISLEDDKKSVLQEAIEKGTWREIEIWLTNGDGTGNIHRIIWPESLLFIKHREGDKKAVIPALTPAKDDFWKNIWEGEYSQLAWGKLSTLLSGMDFNSSDSGSGSSSNTNKELDAGVEWWHVPSALDFGLEWYKGRESRAQKIKERLEEKAAEEKMKQKVAHLAAEAEKAKQLKSMGIGVGIGIGPIGGVYPTPPDAQGVLLGGPASAASTGAAETPGFIHAVTEDWSAQGDPAVNAETDLFGDEEMDGMLKVTDDDFAFFDNDGFGNDAGGMDLDMDMGMPEDKMEITPTTINGGELVPEVMVDNSTLTLPTMPGPQQQQNQPQLLSQQQRSRKRQRETTEPPAVQLEAQNQVQTPPLSPHRAMSLLVPGYSPPNPNYTPPNTGFFKVPQLPSTTTSPDGHVTKRRASMYSPIIFTDNVEKTDMKYAPGGRFFLAEIDTKTPAKEDATRIDRSHLKRKRSTTGRSTATHSRTPREVITIDDDDETTLGSVNGDVSEESDADDTSDEESEDEGEESRYHTSPGMPSMAGPLSFVMPWGGKKRKWPIGTVMEDSLSIDSPASRSVAIGVEGDVEVIPELAPAPWKSMKPDSLDDSLVGVFSSMTITSDPLSAGTFGDAEYVEVATVLASQLTGFLHSVWNGKPETISADEAESSTSLLLRRRCKDQTLVEDAVRTLFKEGNVIRCSLETYASITDSIQAPAPIPPSPPLSSHLHSGISNIKPNPALSQRRNTTAPPLIPIKPWDIFPLPPPHIRLQRGDNILELLPPALHFWETFSLAPISGGKNIIACCFHPSSPQLAEAADFLLDRMTSSYEAGRFGIHHRAEIPGIASSGMIPIPIPPEASPTYEVAMTSLLSHLEGFGPVLANSIADEGQNIVIYLINPFLHPSALVDITTGFIRLKRHYLNTIATIPGAKSNHLTLQIIPASFVAHKLGQQMRVNIIHKLCQEVYSRCIRTDESATQDPRENTPSVVLSRPLPQTINFSITEPSPGLLRENRLLHLVYAQSSDERWTAAAWSDNTGEVERKRVINLGRKGSGYLRPFRDVLKELWITTQELLKSAGVKTRLCITRLIPGGSGSGSGSTFPLDEFTLWQTITHPRLSSLHLLTATLSSPLHLSEVLPEINLATFFPQQNFLTPMANTPTPGATGNSIVSPDASVTTPGTGADTEGLLDADAELVDTQEEMWGVVVGHVMGGLIPILPIQAQASKGTKGPSASLSTSSSSQGKTGLLIRRDAKEEGWKVVVQITAVKGEEVLREVLEGWRGLGVLGAQGVPGVMRFVEGVEGLGFCS
Length1636
PositionKinase
OrganismPyronema omphalodes (strain CBS 100304) (Pyronema confluens)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Pezizomycetes> Pezizales> Pyronemataceae> Pyronema.
Aromaticity0.06
Grand average of hydropathy-0.333
Instability index48.26
Isoelectric point4.96
Molecular weight178167.71
Publications
PubMed=24068976

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
ECO:0000256	RuleBase:RU364134
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP32924
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     105.74|      25|      33|     310|     334|       1
---------------------------------------------------------------------------
  310-  334 (44.30/28.13)	EWGRIIPPS..ESESSILPAS..ESRWKE
  342-  370 (30.61/16.59)	DHGIISPISleDDKKSVLQEAieKGTWRE
  402-  420 (30.82/16.77)	DKKAVIP........ALTPAK..DDFWKN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     532.04|     143|     574|      27|     189|       2
---------------------------------------------------------------------------
   27-  179 (232.81/152.95)	LAVSDDDFIGLDEDRQC...DILRDA.ERTLRAE.GVPVLSDLEnncLWVFHIAGITRVSAGAEEGEILVDDEQPADEKDERWLQIeerLSEEWSLKESSRDIFH...............SSSL....TPPLQAPLTTPFAAITI........DP......MTTAPPTPKTEVIDLtlddEPRPADP.PPPE
  598-  747 (215.89/120.35)	LKVTDDDFAFFDND......GFGNDAgGMDLDMDmGMP.EDKME...ITPTTINGGELVPEVMVDNSTLTLPTMPGPQQQQNQPQL...LSQQQRSRKRQRETTE...............PPAVqleaQNQVQTPPLSPHRAMSLlvpgysppNP......NYTPPNTGFFKVPQL.......PSTT.TSPD
 1007- 1097 (83.35/40.27)	..............RRCkdqTLVEDA.VRTLFKE.GNVIRCSLE.............................................................tyasitdsiqapapiPPS......PPLSSHLHSGISNIKP........NPalsqrrNTTAPP.....LIPI....KPWDIFPlPPP.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     112.39|      36|      82|    1151|    1187|       3
---------------------------------------------------------------------------
 1151- 1174 (34.11/16.93)	............................................................LLDRMTSSYEAGRFGIHHRAEIPG
 1176- 1259 (38.16/21.38)	ASSGMIPIPIPPeasptyevamtsllshlegfgpvlansiadegqniviylinpflhpsaLVDITTGFIRLKRHYLNTIATIPG
 1260- 1287 (40.11/18.40)	AKSNHLTLQIIP......................................................ASFVAHKLGQQMRVNI..
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      85.65|      22|     575|     286|     309|       4
---------------------------------------------------------------------------
  286-  309 (39.61/28.49)	RRLGSSGYtdKSWVERECFIAPWG
  864-  885 (46.04/26.92)	RYHTSPGM..PSMAGPLSFVMPWG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.62|      16|      16|     830|     845|       6
---------------------------------------------------------------------------
  830-  845 (26.19/15.31)	DDETTLGSVNGDVSEE
  847-  862 (26.43/15.52)	DADDTSDEESEDEGEE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.18|      16|      16|     758|     773|       7
---------------------------------------------------------------------------
  758-  773 (29.30/18.93)	YSP..IIFTDNVE.KTDMK
  774-  792 (19.88/10.41)	YAPggRFFLAEIDtKTPAK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      61.54|      17|     971|     448|     466|       8
---------------------------------------------------------------------------
  448-  466 (27.44/19.84)	SGSGSSSNTnkELDAGVEW
 1422- 1438 (34.10/18.57)	SGSGSGSTF..PLDEFTLW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      59.99|      18|      19|    1594|    1612|       9
---------------------------------------------------------------------------
 1594- 1612 (27.80/21.73)	AVKGEEVLReVLEGWRGLG
 1616- 1633 (32.20/20.30)	AQGVPGVMR.FVEGVEGLG
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP32924 with Med13 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) FDNDGFGNDAGGMDLDMDMGMPEDKMEITPTTINGGELVPEVMVDNSTLTLPTMPGPQQQQNQPQLLSQQQRSRKRQRETTEPPAVQLEAQNQVQTPPLSPHRAMSLLVPGYSPPNPNYTPPNTGFFKVPQLPSTTTSPDGHVTKRRASMYSPIIFTDNVEKT
2) KYAPGGRFFLAEIDTKTPAKEDATRIDRSHLKRKRSTTGRSTATHSRTPREVITIDDDDETTLGSVNGDVSEESDADDTSDEESEDEGEESRYHTSPGMPSMAGPLS
3) PFAAITIDPMTTAPPTPKTEVIDLTLDDEPRPADPPPPETLEERN
4) TGAAETPGFIHAVTEDWSAQGDPAVNAETDLFGDEEMDG
5) TPMANTPTPGATGNSIVSPDASVTTPGTGADTEGLLDADA
608
773
141
558
1482
770
879
185
596
1521










Molecular Recognition Features






MoRF SequenceStartStop




NANANA