<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP32923
Description |
Mediator of RNA polymerase II transcription subunit 1 |
Sequence | MTTPNLTGLTPKMAGQTPKMTGSTPSALGSFGFSPALLGQSPMAMLKHSRSPLPSGASPGMLVRLGMTPGMGMQQLPPDETKKRELEEMLKLLAQRPGRISIPAIERLAKGMGLDFYKEDGDAPGVIRLSLAAKIFLLDIEYLGNTIIKAQLALSGNDPQTFQSIDEATKILQSNLVPVAKSPGHYPLFSSSIGDFSENLTRLYRTDKLSTDNLNCFTAISGIYQSLEKIYHYERENMGEMAALCFGNGRPQMHIRGKVGLSIDYWKERRLLNAHGGGKNTEEEEERLWRVLIEVEETPNFGGIPMNHVTPVRSTNHWVSDEIKKHKEDNLFGDLEELTTDWLEPPLEELMEIPGDPTQSKPPSARFVARLDPPLVLPWPEEQALNPSIIPTDIDSFERLLFPSLSPKESTYREIYGSSEDAEATIHNYHLETLALKTVSSRRVTEIPFSHPRDLLRFFHTLRQYALLSTLLESCFSPKHVSKTPPSDGQKPVVMDELDLLLQGFDSSNTPAVGLPVTVSLEPEQGFGLRVVYPDQGGMGNWQVVVGKNGDLKVAAGGNGAMEDRIRKALGAAEDVGLVVEWVRRGMQ |
Length | 588 |
Position | Middle |
Organism | Pyronema omphalodes (strain CBS 100304) (Pyronema confluens) |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Pezizomycetes>
Pezizales> Pyronemataceae> Pyronema.
|
Aromaticity | 0.07 |
Grand average of hydropathy | -0.347 |
Instability index | 51.87 |
Isoelectric point | 5.47 |
Molecular weight | 64965.42 |
Publications | PubMed=24068976
|
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364059
|
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro
|
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro
|
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro
|
Interaction
Repeat regions
Repeats |
>MDP32923
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 74.07| 21| 26| 18| 43| 1
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18- 39 (33.94/24.89) PKMTGSTPSALGSFGFSPAlLG
52- 72 (40.12/15.88) PLPSGASPGMLVRLGMTPG.MG
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 81.67| 25| 26| 193| 217| 2
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193- 217 (42.09/35.13) IGDFSENLTRLYRTDKLSTDNLN..CF
220- 246 (39.58/32.52) ISGIYQSLEKIYHYERENMGEMAalCF
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
3| 200.22| 51| 260| 73| 127| 3
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77- 127 (87.20/44.16) PPDETKKRELEEMLKLLAQRPG...RISIPA...IERLA........KGMGLD.FYKEDGDAPGVI
343- 390 (54.51/21.93) .........LEPPLEELMEIPGdptQSKPPSarfVARLD........PPLVLP.WPEEQALNPSII
485- 537 (58.52/21.93) PPSDGQKPVVMDELDLLLQGFD...SSNTPA...VG.LPvtvslepeQGFGLRvVYPDQG......
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 59.26| 18| 115| 166| 188| 4
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147- 164 (28.85/20.78) IIKAQLALSGNDPQTFQS
171- 188 (30.40/13.49) ILQSNLVPVAKSPGHYPL
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 71.21| 22| 314| 247| 269| 5
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247- 269 (39.61/29.77) GNGRPQMHIR...G...KVGLSIDyWKER
558- 585 (31.60/18.07) GNGAMEDRIRkalGaaeDVGLVVE.WVRR
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