<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP32921

Description Mediator of RNA polymerase II transcription subunit 17
SequenceMSNPPDPNPDTNPDTNPDTNPDTNPDTNPPDTNPSDPLLLSLRHWPSPAPEETSLPTLVHRIHTQRYFNGLTEDTLQAEINASASNDTSDALHDARPTTIPEPPHMVVAKSRMVDYIFHAHNEAMIALDFISLVCSLQAPEIATSSMSPMLKASVPVGCLGHSRLVRKVDKAEVEKEEKIAREWKQQGLVSAADLLLGASKRLGEEVNRERRYWREVLEIREGGWLVTRMPREKNGLGVRYGFAEATLSGIAPLRRGEDGGVRMEQVESGGRMVRVRIMRGGEVTGESWQRVGREGEGIMKSVRKARNSIYEEELFAEVMKEARMYAGMGMKTREDEATVEVGGVSVVVDMAPIDDPNHPFPLMTPDTQLANYIALSLRILLSYNHRLSLSRRSRPPPPMTPHKPTPEPMRLLRPITTYLLHTSHQTHLSTLLRRLCLITTTAGLSSSFTLTPFSNTVGRPITSVETAIDLFIHMLETTASVSLPGGWSLTITMRTALQRPIQGTQYVITTHHDGVSIRQMGEQRFSSEEEAGNYVWWCLERAVVNHIRLMGEWVQEGLGNEMVCKKGRIRVEVQEGVGLVLVWGKQGGRDRKEVWDGTERGRSLAEVLEGIV
Length613
PositionHead
OrganismPyronema omphalodes (strain CBS 100304) (Pyronema confluens)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Pezizomycetes> Pezizales> Pyronemataceae> Pyronema.
Aromaticity0.05
Grand average of hydropathy-0.422
Instability index35.99
Isoelectric point6.18
Molecular weight68378.13
Publications
PubMed=24068976

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU364140
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP32921
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      58.56|      13|      15|       5|      17|       1
---------------------------------------------------------------------------
    5-   17 (31.89/19.62)	PDPNPDTNP.DTNP
   21-   34 (26.67/15.33)	PDTNPDTNPpDTNP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     106.19|      24|      25|     254|     277|       2
---------------------------------------------------------------------------
  230-  252 (29.23/13.93)	MPREKNGlGVRYGFA..EAT..LSGIA
  254-  277 (41.74/22.88)	LRRGEDG.GVRMEQV..ESGGRMVRVR
  279-  304 (35.22/18.22)	MRGGEVT.GESWQRVgrEGEGIMKSVR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      63.59|      18|      18|     556|     573|       3
---------------------------------------------------------------------------
  556-  573 (34.23/24.89)	QEGLGNEMVCKK..GRIRVE
  575-  594 (29.36/20.31)	QEGVGLVLVWGKqgGRDRKE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      39.84|      12|      17|     403|     414|       4
---------------------------------------------------------------------------
  403-  414 (22.91/15.12)	HKPTPEPM.RLLR
  422-  434 (16.94/ 9.00)	HTSHQTHLsTLLR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      59.65|      18|      27|     506|     523|       5
---------------------------------------------------------------------------
  506-  523 (34.66/18.77)	Q..........YVITTHHDGV..SIRQMGE
  524-  553 (25.00/11.94)	QrfsseeeagnYVWWCLERAVvnHIRLMGE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      76.03|      23|      37|     440|     462|       9
---------------------------------------------------------------------------
  440-  462 (39.61/32.07)	TTTAGLSSSFTLT.PFSNTVGRPI
  479-  502 (36.42/28.72)	TASVSLPGGWSLTiTMRTALQRPI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      36.69|      11|      30|     173|     186|      11
---------------------------------------------------------------------------
  173-  186 (15.09/16.26)	EVEKEEkiaREWKQ
  206-  216 (21.60/13.09)	EVNRER...RYWRE
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP32921 with Med17 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) GLTEDTLQAEINASASNDTSDALHDARPTTIPEPPHM
2) MSNPPDPNPDTNPDTNPDTNPDTNPDTNPPDTNPSDPLLLSLRHWPSPAPEETSLPTLVHRIHT
70
1
106
64










Molecular Recognition Features






MoRF SequenceStartStop




NANANA