<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP32917
Description |
Mediator of RNA polymerase II transcription subunit 16 |
Sequence | MCDLRRPAAGGMMDLAYVCEWEKWSKSTHCPSVPLACAWSCRNLIAFTMDLRSDDQDLTRMIHILDTEHPWDLHSIPSEHHEAITCLEWDQSGSRLLSADADGQIKCWSMADHLANSWESSVGSLVEGDPIVALSWLHNGVKLALHVEKSGASSFGEKFSRVKFSPSLTLFGGKPMEGWIAVTVSGLVTVSLLKPSGQVLTSTESLCRLRGRVALADIAFTGGGNIVVATADGSSASPVQFYKVCVSVVSEKCRIDTEILPSLFMRCTTDLNRKDKFPAITHLKFLARDMSEQVLLCASSQTSSIVECWSLRKEGLPVNNIFQQISPVVGDKQPTILKWRILSATNDLDRVSAVALPKLPISLTNTDLKVASDTQFYPGLGLALAFHDGSVHIVHRLSLQTMAVFYSSAAPRPVDEPAMKRPRTAGPAVHLKAMQLSWTSLALVGIDSHGKLSVLRLSPSMGHPLEVGLALRHLLFLLEYCMVTGYDWWDILLHVQPSMVQSLVEKLHEEYTRQTAALQQVLSTRILAMKASLCKLSPCTVTRVCDYHTKLFLIAISSTLKSLLRPHFLNTPDKSPGDRLTEICTKITDVDIDKVMINLKTEEFVLDMNTLQALQQLLQWVGDFVLYLLASLPNQPSPTSEPSPTSEPCPTSEPSPTSEPSSP |
Length | 663 |
Position | Tail |
Organism | Homo sapiens (Human) |
Kingdom | Metazoa |
Lineage | Eukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia>
Eutheria> Euarchontoglires> Primates> Haplorrhini> Catarrhini> Hominidae>
Homo.
|
Aromaticity | 0.06 |
Grand average of hydropathy | 0.027 |
Instability index | 49.85 |
Isoelectric point | 6.24 |
Molecular weight | 72950.45 |
Publications | PubMed=15057824
|
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364149
|
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro
|
GO - Biological Function | catalytic activity GO:0003824 IEA:InterPro
|
GO - Biological Process | |
Interaction
Repeat regions
Repeats |
>MDP32917
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
3| 325.13| 107| 200| 1| 136| 1
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22- 136 (188.22/177.96) EKWSKSTHCPSVPLACAWSCRNLIAFTMD.......LRSDDQDLTrmihilDTEHPWDLHSIPSEHHEAITCLEW...DQSGSRLL..SADADGQIKCWSM.ADHL.ANSWESSVGSLVeGD..PIVaLSW
157- 233 (94.76/49.53) EKFSRVKFSPSLTLFGGKPMEGWIAVTVSglvtvslLKPSGQVLT......STESLCRLRGRVALADIAFT.........GGGNIV..VATADG.....................................
279- 339 (42.15/13.99) ....................................................................AITHLKFlarDMSEQVLLcaSSQTSSIVECWSLrKEGLpVNNIFQQISPVV.GDkqPTI.LKW
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|
Associated diseases