Description | Mediator of RNA polymerase II transcription subunit 19 |
Sequence | PPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPEVQAVARPGAEGLGVSSGPFLLPISSRGYTGTTELTGSTNLITHYNLEHAYNKFCGKKVKEKLSNFLPDLPGMIDLPGSHDSSSLRSLIEKPPICGSSFTPLTGAMLTGFRLHAGPLPEQCRLMHIQPPKKKNKHKHKQSRTQDPVPPETPSDSDHKKKKKKKEEDPERKRKKKEKKKKKNRHSPEHPGVGSSQASSSLR |
Length | 232 |
Position | Head |
Organism | Ficedula albicollis (Collared flycatcher) (Muscicapa albicollis) |
Kingdom | Metazoa |
Lineage | Eukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Archelosauria> Archosauria> Dinosauria> Saurischia> Theropoda> Coelurosauria> Aves> Neognathae> Passeriformes> Muscicapidae> Ficedula. |
Aromaticity | 0.03 |
Grand average of hydropathy | -1.106 |
Instability index | 81.81 |
Isoelectric point | 9.93 |
Molecular weight | 25204.75 |
Publications |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364151 |
GO - Cellular Component | mediator complex GO:0016592 IEA:Ensembl |
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro |
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro |
Binary Interactions |
Repeats | >MDP32907 --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 89.12| 15| 16| 1| 15| 1 --------------------------------------------------------------------------- 1- 15 (44.56/ 9.16) PPPPPPPPPPPPPPP 18- 32 (44.56/ 9.16) PPPPPPPPPPPPPPP --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 3| 79.99| 16| 17| 180| 195| 2 --------------------------------------------------------------------------- 160- 173 (25.39/12.51) P..PKKKNKHKHKQSR 180- 195 (27.41/14.12) PETPSDSDHKKKKKKK 199- 214 (27.19/13.95) PERKRKKKEKKKKKNR --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 57.04| 16| 112| 100| 118| 4 --------------------------------------------------------------------------- 100- 118 (27.07/18.04) PDLPGmidLPGSHDSSSLR 217- 232 (29.97/13.13) PEHPG...VGSSQASSSLR --------------------------------------------------------------------------- |
MoRF Sequence | Start | Stop |
1) DSDHKKKKKKKEEDPERKRKKKEKKKKKNRHSPEHP 2) PPPPPPPPPPPPPPPPPPPP | 185 1 | 220 20 |
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