<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP32897

Description Mediator of RNA polymerase II transcription subunit 15
SequenceMDVTGPETDWRSTNFRQKLVSQIDEAMRKAGVAHNKTSKDMESHVFMKAKTREEYLSLVARLIIHFRDIHNKKSQASVSDPMNALQNLTGGPTAGAPGMGMASRAQGAPMAGMTGLGPMAQQMSLPGQQQPPGTSGMAPHGMPGVSTATQQTQLQLQQIAQQQQQQQQQFQQQQVALQQQQQFQAQQSAMQQQFQVQQQQAAAAAVVQQQQQQQQQLQAVQQQQQHMLKLQMQQQQNQQQMQQQQQQQQLQRIAQMQQLQAAQVMQAQQQQQQQQQQQQQIPQQQIQQQPPQQVMQQQMQQMQQQQQQQQQQQQQQQQVAQAQQPQLPPQSQPQPQPMVSQPQAISGQIPGQVMPVTLTPQQLKAMQVRAQLVQQQQQQAAAAVQAAQAQAAQMGASGQMITAPMARGGMQIRPRFPPSTAVSATAPSSMPLGGQQMPQVSQNNITMMSSPSPVQQAQTPQSMPPPPQPQPSPQPGQPTSQPNSNVSSGPAPSPSSFLPSPSPQPSQSPAAARTPQNFSVPSPGPLNTPGNPNSVMSPASSGQSEEQQYLEKLKQLSKYIEPLRRMINKIDKNEDRKKDLSKMKSLLDILTDPSKRCPLKTLQKCEIALEKLKNDMAVPTPPPPPVPPTKQQYLCQPLLDAVLANIRSPVFNHSLYRTFMPAMTAIHGQPITAPIASPRKRKYEEDERQTIPNVLQGEVARLNPKFLVNLDPSHCSNNGTVHLICKLDDKNLPNVPPLQLSVPADYPDQSPLWIKNPRQYAANPFLQSVYRYMTSKLLQLPDKHSVTALLNTWAQSIRQACLSAA
Length805
PositionTail
OrganismFicedula albicollis (Collared flycatcher) (Muscicapa albicollis)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Archelosauria> Archosauria> Dinosauria> Saurischia> Theropoda> Coelurosauria> Aves> Neognathae> Passeriformes> Muscicapidae> Ficedula.
Aromaticity0.03
Grand average of hydropathy-0.803
Instability index83.13
Isoelectric point9.80
Molecular weight89123.19
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364148

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
nucleoplasm	GO:0005654	IEA:Ensembl

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP32897
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     162.45|      34|      35|     258|     292|       1
---------------------------------------------------------------------------
  162-  192 (50.56/ 7.51)	QQQQQQ..Q...QFQQQQV..ALQQQQQFQAQQSAMQQ
  248-  283 (55.36/ 9.13)	QQLQR..IAqmqQLQAAQVMQAQQQQQQQQQQQQQIPQ
  284-  321 (56.53/12.08)	QQIQQQpPQqvmQQQMQQMQQQQQQQQQQQQQQQQVAQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     606.33|     129|     129|     322|     450|       2
---------------------------------------------------------------------------
  120-  244 (112.31/20.57)	AQQMS.LPGQQQP...P........GTSGMAPHG.MP..gVsTATQQtQLQLQQIaqqqqqqqqqfqqqqvalqqqqqfqaqqsamqqQFQ.VQQQQAAAAAVVQQQQQQQQQLQAVQQQ.QQHML....K................LQMQ..................................qQQ.........NQQQM.............................................QQQ
  322-  450 (237.04/52.98)	AQQPQ.LPPQSQPQPQPMVSQP..QAISGQIPGQVMP...V.TLTPQ.QLKAMQV.................................RAQLVQQQQQQAAAAVQAAQAQAAQMGASGQMITAPMA....R................GGMQIRPRF.....PPSTAVSATAPSSMPLGGQQMPQV.SQ.........NNITM.............................................MSS
  457-  618 (139.80/27.71)	AQTPQsMPPPPQPQPSP...QP......GQPTSQ..PnsnV.SSGPA.PSPSSFL.................................PSPSPQPSQSPAAA..RT..PQNFSVPSPG.....PLN....T................PG...NPNS.....VMSPASSGQSEEQQYL..EKLKQL.SKyieplrrmiNKI..dknedrkkdlskmkslldiltdpskrcplktlqkceialeklkndMAV
  619-  735 (117.18/21.84)	PTPP...PPPVPPTKQQYLCQPllDAVLANIRSPVFN...H.SLYRT....FM.........................................................PAMTAIHGQPITAPIAsprkRkyeederqtipnvlqgEVARLNPKFlvnldPSHCSNNGTVHLICKLDDKNLPNV.................................................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.19|      12|      15|      90|     101|       3
---------------------------------------------------------------------------
   90-  101 (26.21/14.07)	GGPTAGAPGMG.M
  107-  119 (20.97/ 9.83)	GAPMAGMTGLGpM
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP32897 with Med15 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) HNKKSQASVSDPMNALQNLTGGPTAGAPGMGMASRAQGAPMAGMTGLGPMAQQMSLPGQQQPPGTSGMAPHGMPGVSTATQQ
2) QQQQQQAAAAVQAAQAQAAQMGASGQMITAPMARGGMQIRPRFPPSTAVSATAPSSMPLGGQQMPQVSQNNITMMSSPSPVQQAQTPQSMPPPPQPQPSPQPGQPTSQPNSNVSSGPAPSPSSFLPSPSPQPSQSPAAARTPQNFSVPSPGPLNTPGNPNSVMSPASSGQSEEQQYLEKLKQ
3) QVAQAQQPQLPPQSQPQPQPMVSQPQAISGQIPGQVMPVTLTPQ
70
374
318
151
555
361










Molecular Recognition Features






MoRF SequenceStartStop




NANANA