<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP32885

Description Mediator complex subunit 14
SequenceMISSFLDQQAILFVDTADRLASLARDALVHARLPSFAIPYAIDVLTTGSYPRLPTCIRDKIIPPDPITKSEKQTTLHQLNQILRHRLVTTDLPPQLANLTVANGRVKFRVEGEFEATLTVMGDDPDIPWRLLKLEILVEDKETGDGRALVHSMQINFIHQLVQSRLFADEKPLQDMYNCLHSFCLALQLEVLHSQTLMLIRERWGDLVQVERYHAGKCLSLSVWNQQVLGRKTGTASVHKVTIKIDETDVSKPLQISHEPPLPVCDSKLMERAMKIDHLSIEKLLIDSVHARSHQKLQELKAILKTYNVNDNSFIETALPTLVIPILEPCGRSECLHVFVDLHSGMFQLMLYGVDQQTLDDIEKSVNDDMKRIIPWLQQLKFWLGQQRCKQSIKHLPTVSSETLQLANYASHPVGNLSKHKLFIKLTRLPQYYIVVEMFDVPGNPTELEYKYHFLSVSYAEGDDSPATALLLQQFKPNIEELVLDTKSGKQVKSGVKRKLSGDPCSIEPKKPKRSGEMCAFNKVLAHIVAMCDTNMPFIGLRIELSNMDIPHQGVQVEGDGFSHAIRLLKIPPCKGVNEETQKALDRSLLDCTFRLQGRNNRTWVAELVFANCPLNSTSSREQGPTRHVYLTYENQLSEPVGGRKVVEMFLNDWNSIARLYECVLEFARSLPDIPSHLNIFSEVRIYNYRKLILCYGTTKGSSISIQWNSILQKFHISLGTVGPNSGCSNCHNTILHQLQEMFNKTPNVVQLLQVLFDTQAPLNAINKLPTVPMLGLTQRTNTAYQCFSILPQSPTHIRLAFRNMYCIDIYCRSRGVVAIRDGAYSLFDNSKIVEGFYPAPGLKTFLNMFVDSNQDARRRSVNEDDNPPSPIGGDMMDSLISQLQPQQPPQQPQQQPFAKQAGASGAYPLTSPPTSYHNTVTPSPSMMHTQSPGNLHAASSPSGALRAPSPASFGPTPSPSSLGITMGQTANFASPHGTIDPSSPYTMMSPSQRAGNWPGSPQVSGPSPAARMPGMSPANPSLHSPVPDASHSPRAGTSSQVMPTSMPPPRKLPQRSWAASIPTILTHSALNILLLPSPTPGLVPGLAGSYLCSPLERFLGSVIMRRHLQRIIQQETLQLINSNEPGVIMFKTEALKCRVALNPKTNQTLQLKVTPENTGQWKSEELQVLEKFFETRVAGPPFKANTLIAFTKLLGAPTHILRDCVHIMKLELFPDQASQLKWNVQFCLTIPPSAPPIAPPGTPAVVLKSKMLFFLQLTQKTTVPQEAVSIIVPIIYDMASGTTQQADIPRQQNSSVAAPMMVSNILKRFAELNSPRPGECTIFAAVRDLMVNLTLPPGGRP
Length1342
PositionTail
OrganismFicedula albicollis (Collared flycatcher) (Muscicapa albicollis)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Archelosauria> Archosauria> Dinosauria> Saurischia> Theropoda> Coelurosauria> Aves> Neognathae> Passeriformes> Muscicapidae> Ficedula.
Aromaticity0.07
Grand average of hydropathy-0.203
Instability index55.66
Isoelectric point8.70
Molecular weight149039.35
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coactivator activity	GO:0003713	IEA:Ensembl

GO - Biological Process
positive regulation of transcription initiation from RNA polymerase II promoter	GO:0060261	IEA:Ensembl
stem cell population maintenance	GO:0019827	IEA:Ensembl









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP32885
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     258.06|      56|      56|     869|     924|       1
---------------------------------------------------------------------------
  869-  924 (97.70/40.19)	PSP.IGGDMMDS..LIS.QLQPQQPPQQPQQQPFAKQ..AGASG...AY.PLTSPPTSYHNTVT.........PS
  925-  983 (94.14/38.48)	PSM.MHTQSPGN..LHA.ASSPSGALRAPSPASFGPT..PSPSSlgiTM.GQTANFASPHGTID.........PS
 1009- 1078 (66.22/25.04)	PAArMPGMSPANpsLHSpVPDASHSPRAGTSSQVMPTsmPPPRK.....lPQRSWAASIPTILThsalnilllPS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     523.61|     170|     510|      33|     263|       2
---------------------------------------------------------------------------
   62-  263 (263.13/312.00)	IPPDPITKSEKQTTLHQLNQILRHRLVTTDLPPQLANLTVAN...GRVKFRVEGefeatltvmgddpdiPWRLLKLEILVEDKETGDGRALVHSM..QINFIHQLVQSRL.FAdeKPLQDMYNCLHSFClalQLEVLHSQTLMLirerwgdlvqVerYHAGKCLSLSV.WNQ..Q.......VLGRKTGTASVHKVTI.KIDE.....TDVSKPLQISHEPPLP
  571-  762 (260.48/181.30)	IPPCKGVNEETQKALDRSLLDCTFRLQGRNNRTWVAELVFANcplNSTSSREQG...............PTRHVYLTYENQLSEPVGGRKVVEMFlnDWNSIARLYECVLeFA..RSLPDIPSHLNIFS...EVRIYNYRKLIL..........C..YGTTKGSSISIqWNSilQkfhislgTVGPNSGCSNCHNTILhQLQEmfnktPNVVQLLQVLFDTQAP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     152.45|      49|      56|     298|     352|       3
---------------------------------------------------------------------------
  298-  352 (74.66/59.29)	QELKAILKTynVNDN.SFIETALPTLVIPIlepcGRSECLHVFVDL...HSGMFQLMLY
  357-  409 (77.79/45.24)	QTLDDIEKS..VNDDmKRIIPWLQQLKFWL....GQQRCKQSIKHLptvSSETLQLANY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      96.51|      29|     478|     770|     842|       4
---------------------------------------------------------------------------
  776-  810 (42.04/78.76)	GLTQRTNTAYqCFSILPQSPTHIrlaFRNmyCIDI
 1180- 1208 (54.47/11.96)	GPPFKANTLI.AFTKLLGAPTHI...LRD..CVHI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     130.44|      39|    1300|       1|      39|       8
---------------------------------------------------------------------------
    1-   39 (64.87/46.77)	MISSFLDQQAILFVDTADRLASLA..RDALVHARLPSFAIP
 1302- 1342 (65.57/47.37)	MVSNILKRFAELNSPRPGECTIFAavRDLMVNLTLPPGGRP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP32885 with Med14 domain of Kingdom Metazoa
Unable to open file!