<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP32882

Description Mediator of RNA polymerase II transcription subunit 1
SequenceVTEAEKLNKMSSLLERLHAKYSQNRPWAETMKLVRQVMEKRVVLNSGRHQHLVSCLETLQKALKVSSLPAMTDRLESIARQSGLGSHLSANGTECYITSDMFYVEVQLDPTGLLCDVKVAHHGENPVSCPELVQHLREKNFDEFSKHLRGLVNLYKLPGDNKLKTKMYLALQSLELDLQKMAGMYWQATNANPLDKILHGSVGYLTPRSGGLLMNLKYYVSPYDLFEDGTGAPVVLHENNVPRSLGMNVSVTVEGTMAMHKLPIAPLIMGSHPVDSKGTPSFSSITSANSVDLPACFFLKFPRPIPVSRAFIQKLQSCTGIPLFDTAPTFVPLYELITQFELSKEADPLPLNHNMRFYAALPGQQHCYFLNKDAPLPDGRSLQGTLLSKIAFQHPGRVPLILNLIRHQVAYNTLIGSCVKRTVLKEDSPGILQFEVCPLSDSCFSVSFQHPVNDSLVCVVMDVQDSSHVNCKLYKGLSDALICTDDFIAKVVQRCMSIPVTMRAIRRKAETIQADTPALSLIAETVEDMVKKNLPPASSPGYGMTTGSNPMSGTTTPTNTFPGGPITTLFNMSISMKERHDSVGHGEDFSKVSQNPILTSLLQITGNVGSTIGSSPTPPHHTPPPVSSPASNTKNHPMLMNLLKENPPQDFSTLYGSSPLERQNSSSGSPRMEMGPGGNKQKKKKSRMPADKPKHQTEDDFQRELFSMDVDSQNPIFDVNMTADTLDTPHITPAPSQCSTPPTTYPQALPHAQPSIQRMVRLSSSDSIGADVTDILSDIAEEASKLPTSTEDCPPIGTPVRDSSSSGHSQSALFDPDVFQTNSSENPYTDPADLIADAAVSPSSDSSNHFFPDGVDFNPDLLNSQSQSGFGEEYFDESSQSGDTDDFKGYAPQALTNLGVQVLGADGGENKFKGSTPSDTVDFSIIAAASKALGSSDIMEHHSGGQSPLLNTGDLGKEKSQKRVKEGNGSGGAMAGAGMDGKPGKRSRTPSSDGKSKEKLPKRKKQETDGKSPSHSSSNRPFTPPASTGGSKSPGTSGRSQTPPGVATPPIPKITIQIPKGTVTVGKPSSHGQYTSSGSVTSSSSKSHHSHSSSSSSSSSSSTSGKIKSKSEGSSGSKMSSSLYSSQGGSGSGQSKGSAQSVGKPGSSPITKHGLSTGSGSTKMKPQGKPSSLMNPSMSKPNISPSHSRPSGGSDKLASPMKPVPGTPPSSKAKSPISSGSGGSHMSGTGSSSSMKSSSGMGSSGSMSQKPPPSSNSSTASSSSFSSSGSSMSSSQNQHGSSKGKSPSRNKKPSLTAVIDKLKHGVVTSGPGGDDPMDGQMGPSSNSSSHTMSSKHNMSGGEFQGKREKSDKEKSKVSVSGGSVDSSKKNSDSKNVGSTGVAKIIISKHDGGSPSIKAKVTLQKPGEGGGDGLRPQMASSKSYGSPLISGSTPKHERCSPSHSKSPAYTPQNIDSESESGSSIAEKSYQNSPSSDDGIRPLPEYSAEKHKKHKKEKKKVKDKERDREREREKDRDKKKSHGMKPESWSKSPISAEQSLAMASSAILSAERPSRASPEFLIGEEDDDLMDVALIGN
Length1575
PositionMiddle
OrganismFicedula albicollis (Collared flycatcher) (Muscicapa albicollis)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Archelosauria> Archosauria> Dinosauria> Saurischia> Theropoda> Coelurosauria> Aves> Neognathae> Passeriformes> Muscicapidae> Ficedula.
Aromaticity0.04
Grand average of hydropathy-0.630
Instability index55.24
Isoelectric point8.91
Molecular weight167185.25
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:Ensembl
nucleolus	GO:0005730	IEA:Ensembl
nucleoplasm	GO:0005654	IEA:Ensembl

GO - Biological Function
DNA binding	GO:0003677	IEA:Ensembl
estrogen receptor binding	GO:0030331	IEA:Ensembl
LBD domain binding	GO:0050693	IEA:Ensembl
nuclear receptor coactivator activity	GO:0030374	IEA:Ensembl
peroxisome proliferator activated receptor binding	GO:0042975	IEA:Ensembl
promoter-specific chromatin binding	GO:1990841	IEA:Ensembl
protein-containing complex binding	GO:0044877	IEA:Ensembl
retinoic acid receptor binding	GO:0042974	IEA:Ensembl
thyroid hormone receptor binding	GO:0046966	IEA:Ensembl
transcription corepressor activity	GO:0003714	IEA:Ensembl
vitamin D receptor binding	GO:0042809	IEA:Ensembl

GO - Biological Process
androgen biosynthetic process	GO:0006702	IEA:Ensembl
angiogenesis	GO:0001525	IEA:Ensembl
animal organ regeneration	GO:0031100	IEA:Ensembl
brain development	GO:0007420	IEA:Ensembl
cell morphogenesis	GO:0000902	IEA:Ensembl
cellular response to epidermal growth factor stimulus	GO:0071364	IEA:Ensembl
cellular response to hepatocyte growth factor stimulus	GO:0035729	IEA:Ensembl
cellular response to thyroid hormone stimulus	GO:0097067	IEA:Ensembl
embryonic heart tube development	GO:0035050	IEA:Ensembl
embryonic hemopoiesis	GO:0035162	IEA:Ensembl
embryonic hindlimb morphogenesis	GO:0035116	IEA:Ensembl
enucleate erythrocyte development	GO:0048822	IEA:Ensembl
fat cell differentiation	GO:0045444	IEA:Ensembl
intracellular steroid hormone receptor signaling pathway	GO:0030518	IEA:Ensembl
keratinocyte differentiation	GO:0030216	IEA:Ensembl
lens development in camera-type eye	GO:0002088	IEA:Ensembl
liver development	GO:0001889	IEA:Ensembl
megakaryocyte development	GO:0035855	IEA:Ensembl
monocyte differentiation	GO:0030224	IEA:Ensembl
mRNA transcription by RNA polymerase II	GO:0042789	IEA:Ensembl
negative regulation of apoptotic process	GO:0043066	IEA:Ensembl
negative regulation of keratinocyte proliferation	GO:0010839	IEA:Ensembl
negative regulation of neuron differentiation	GO:0045665	IEA:Ensembl
negative regulation of transcription by RNA polymerase II	GO:0000122	IEA:Ensembl
peroxisome proliferator activated receptor signaling pathway	GO:0035357	IEA:Ensembl
positive regulation of erythrocyte differentiation	GO:0045648	IEA:Ensembl
positive regulation of G0 to G1 transition	GO:0070318	IEA:Ensembl
positive regulation of gene expression	GO:0010628	IEA:Ensembl
positive regulation of hepatocyte proliferation	GO:2000347	IEA:Ensembl
positive regulation of interferon-gamma-mediated signaling pathway	GO:0060335	IEA:Ensembl
positive regulation of intracellular estrogen receptor signaling pathway	GO:0033148	IEA:Ensembl
positive regulation of keratinocyte differentiation	GO:0045618	IEA:Ensembl
positive regulation of transcription initiation from RNA polymerase II promoter	GO:0060261	IEA:Ensembl
protein import into nucleus	GO:0006606	IEA:Ensembl
regulation of vitamin D receptor signaling pathway	GO:0070562	IEA:Ensembl
retinal pigment epithelium development	GO:0003406	IEA:Ensembl
thyroid hormone generation	GO:0006590	IEA:Ensembl
thyroid hormone mediated signaling pathway	GO:0002154	IEA:Ensembl
ventricular trabecula myocardium morphogenesis	GO:0003222	IEA:Ensembl









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP32882
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
            10|    1022.62|     111|     116|    1113|    1223|       1
---------------------------------------------------------------------------
  536-  636 (60.77/12.69)	..............................................PASSP....GYGMT..TGsnpmSGTttpTNTFPGGPIT.........................TLFNMSIS...M...KERHDSVGH...GEDFSkvsqnpiltsllqitgnvgstigSSPTPPHHTPPPVS....S.PASNT...KNH
  645-  769 (111.31/29.36)	E..NPPQDF.STLYGSSPLERQN.S..........SSGS.PRMEMGPGGNK..QKKK.............K...SRM.PADKPKhqteddfqrelfsmdvdsqnpifdvNMTADTLDTPHI...TPA...PSQ...CSTPP.......................TTYPQALPHAQPSIQR.MV.RLSSS..dSIG
  782-  883 (107.77/28.19)	....EASKLPT...STEDCPPIG.T..........PVRD.SSSSGHSQSAL..FDPDVFQ..TN....SSE......NPYTDPA.........................DLIADAAVSPSS..dSSNHFFPDGvdfNPDLL.......................NSQSQSGFGEEYFDE.......SSQ...SGD
  889-  945 (68.94/15.39)	G............YAPQALTNLGvQ..........VLGA.................DG...........GE...NKFKGST.PS.........................DTVDFS.....I...IAAASKALG...SSD.............................................IMEHH...SGG
  953- 1030 (96.55/24.50)	G..DLGKEKSQK..RVKEGNGSG.G..........AMAG.AGMDGKPGKRS..RT..PSS..DG....KSK...EKL.PKRK...................................KQETdgkSPSHS....................................SSNRPF..TPPAS..............TGG
 1035- 1106 (83.28/20.12)	G..TSG........RSQTPPGVA.TppipkitiqiPKGT.V.TVGKPSS.......HGQY..TS....SGS........................................VTSSSSK........SHH........SH....................................SSSSS.SS.SSSST...SGK
 1113- 1223 (200.11/58.65)	G..SSGSKMSSSLYSSQGGSGSG.Q..........SKGS.AQSVGKPGSSP..ITKHGLS..TG....SGS...TKMKPQGKPS.........................SLMNPSMSKPNI...SPSHSRPSG...GSDKL.......................ASPMKPVPGTPPSSKA.KS.PISSG...SGG
 1261- 1341 (92.55/23.17)	...................................SSSS.FSSSGSSMSSS..QNQHGSS..KG....KSP...SRNK...KPS...........................LTAVIDKLKH...GVVTSGP.G...GDD...........................PMDGQMG..PSSNS.SShTMSSKhnmSGG
 1345- 1433 (91.81/22.93)	GkrEKSDKEKSKV.SVSGGSVDS.S..........KKNSdSKNVGSTGVAKiiISKH..D..GG....SPS...IKAK...................................VTLQKPGE...........G...GGDGL.......................RPQM.......ASSKSyGS.PLISG...STP
 1437- 1533 (109.54/28.78)	R..CSPSHSKSPAYTPQNIDSES.E..........S.GS.SIAEKSYQNSP..SSDDGIRplPE....YSA...EKHKKHKKEK.........................KKVKDKERDRER...EREKDR........DK............................KKSHGMKPESWS.KS.PIS........
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     399.47|     127|     185|     194|     339|       2
---------------------------------------------------------------------------
  194-  339 (204.01/182.91)	LDKILHGSVGYLTPRSGGLLMNLKYYVSPYDLFEDGTGAPVVLHENNvPRSLGMNVsvtvegtmamhklpiAPL......IMGSHPVDSKGTPSFSSITSANSVDlpaCFFLK.FPRPIPVSRAFIQK.LQSCTGIPLF........DTAPTFVPLYELITQ
  382-  524 (195.46/136.01)	LQGTLLSKIAFQHPGRVPLILNLIRHQVAYNTLIGSCVKRTVLKEDS.PGILQFEV...............CPLsdscfsVSFQHPVNDSLVCVVMDVQDSSHVN...CKLYKgLSDALICTDDFIAKvVQRCMSIPVTmrairrkaETIQADTPALSLIAE
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP32882 with Med1 domain of Kingdom Metazoa
Unable to open file!