<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP32876

Description Mediator complex subunit 14
SequenceRKIEIVQFASRTRQLFVRLLALVKWANNAGKVEKCAMISSFLDQQAILFVDTADRLASLARDALVHARLPSFAIPYAIDVLTTGSYPRLPTCIRDKIIPPDPITKSEKQTTLHQLNQILRHRLVTTDLPPQLANLTVANGRVKFRVEGEFEATLTVMGDDPDIPWRLLKLEILVEDKETGDGRALVHSMQINFIHQLVQSRLFADEKPLQDMYSCLHSFCLALQLEVLHSQTLMLIRERWGDLVQVERYHAGKCLSLSVWNQQVLGRKTGTASVHKVTIKIDETDVSKPLQISHEPPLPACDSKLMERAMKIDHLSIEKLLIDSVHARSHQKLQELKAILKSYNVNDNSFIETALPTLVIPILEPCGRSECLHVFVDLHSGMFQLMLYGADQLTLDDIEKSVNDDMKRIIPWLQQLKFWLGQQRCKQSIKHLPTVSSETLQLANYASHPVGNLSKHKLFIKLTRLPQYYIVVEMFDVSGNPTELEYKYHFLSVSYAEGDDSPATALLLQQFKPNIEELVLDTKSGKQMKSGVKRKLSGDTCSIEPKKPKRSGEMCAFNKVLAHIVAMCDTNMPFIGLRMELSNMDIPHQGVQVEGDGFSHAIRLLKNRIPPCKGVNEETQKALDRSLLDCTFRLQGRNNRTWVAELVFANCPLNSTSSREQGPTRHVYLTYENQLSEPVGGRKVVEMFLNDWNSIARLYECVLEFARSLPDIPNHLNVFSEVRIYNYRKLILCYGTTKGSSISIQWNSILQKFHISLGTVGPNSGCSNCHNTILHQLQEMFNKTPNVVLLLQVLFDTQAPLNAINKLPTVPMLGLTQRTNTAYQCFSILPQSPTHIRLAFRNMYCIDIYCRSRGVVAIRDGAYSLFDNSKIVEGFYPAPGLKTFLNMFVDSNQDARRRSVNEDDNPPSPIGGDMMDSLISQLQPQQPPQQPQQQPFAKQAGASGAYPLTSPPTSYHNTVTPSPSMMHTQSPGNLHAASSPSGALRAPSPASFGPTPSPSSLGITMGQTANFASPHGTIDPSSPYTMMSPSQRAGNWPGSPQVSGPSPAARMPGMSPANPSLHSPVPDASHSPRAGTSSQAMPTSMPPPRKLPQRSWAASIPTILTHSALNILLLPSPTPGLVPGLAGSYLCSPLERFLGSVIMRRHLQRIIQQETLQLINSNEPGVIMFKTEALKCRVALNPKTNQTLQLKVTPENTGQWKSEELQVLEKFFETRVAGPPFKANTLIAFTKLLGAPTHILRDCVHIMKLELFPDQASQLKWNVQFCLTIPPSAPPIAPPGTPAVVLKSKMLFFLQLTQKTTVPQEAVSIIVPIIYDMASGTTQQADIPRQQNSSVAAPMMVSNILKRFAELNSPRPGECTIFAAVRDLMVNLTLPPGGRP
Length1380
PositionTail
OrganismAnas platyrhynchos platyrhynchos (Northern mallard)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Archelosauria> Archosauria> Dinosauria> Saurischia> Theropoda> Coelurosauria> Aves> Neognathae> Galloanserae> Anseriformes> Anatidae> Anatinae> Anas.
Aromaticity0.07
Grand average of hydropathy-0.200
Instability index54.35
Isoelectric point8.93
Molecular weight153351.46
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP32876
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     261.03|      56|      56|     907|     962|       1
---------------------------------------------------------------------------
  907-  962 (97.85/46.11)	PSP.IGGDMMDS..LIS.QLQPQQPPQQPQQQPFAKQ..AGASG...AY...PLTSPPTSYHNTVTPS
  963- 1021 (93.68/43.82)	PSM.MHTQSPGN..LHA.ASSPSGALRAPSPASFGPT..PSPSSlgiTM...GQTANFASPHGTIDPS
 1047- 1107 (69.50/30.53)	PAArMPGMSPANpsLHSpVPDASHSPRAGTSSQAMPTsmPPP.......rklPQRSWAASIPTILTHS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     194.95|      65|     282|     398|     548|       2
---------------------------------------------------------------------------
  260-  348 (89.99/59.48)	WNQQV...LGRKTGTASV.HKVTIKidetdvSKPLQISHEPPLPacdsklmeramkIDHLSIEKLLIdsvharSHQKLQELKAILKSYNVNDN
  412-  480 (104.96/170.03)	WLQQLkfwLGQQRCKQSIkHLPTVS......SETLQLANYASHP............VGNLSKHKLFI......KLTRLPQYYIVVEMFDVSGN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     325.44|      89|     478|     786|     880|       4
---------------------------------------------------------------------------
  786-  880 (148.02/108.98)	NVVLLLQVlfDTQAPLNAINKLPTVPM.......LGLTQRTNTAYQCFSILPQSPTHIRLAFRNMYCIDIYCRSRGVVAirdgAYSLFDN..SKIVEGFYPAPG
 1205- 1246 (42.30/19.08)	...............LQVLEKFFETRV.......AGPPFKANTLI.AFTKLLGAPTHI...LRD..CVHI..................................
 1262- 1357 (135.12/84.85)	NVQFCLTI..PPSAPPIAPPGTPAVVLkskmlffLQLTQKTTVPQEAVSII..VPIIYDMASGTTQQADIPRQQNSSVA....APMMVSNilKRFAELNSPRPG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     413.22|     131|     510|      69|     250|       5
---------------------------------------------------------------------------
   98-  250 (204.29/203.22)	IPPDPITKSEKQTTLHQLNQILRHRLVTTDLPPQLANLTVAN...GRVKFRVEGefeatltvmgddpdiPWRLLKLEILVEDKETGDGRALVHSM..QINFIHQLVQSRL.FAdeKPLQDMYSCLHSFClalQLEVLHSQTLML.........IRERWGDLVQveRYH
  609-  754 (208.92/117.48)	IPPCKGVNEETQKALDRSLLDCTFRLQGRNNRTWVAELVFANcplNSTSSREQG...............PTRHVYLTYENQLSEPVGGRKVVEMFlnDWNSIARLYECVLeFA..RSLPDIPNHLNVFS...EVRIYNYRKLILcygttkgssISIQWNSILQ..KFH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.84|      19|     495|     372|     405|       6
---------------------------------------------------------------------------
  372-  405 (20.75/44.91)	LHVFVDlhsgmfqlmlygADQltlDDIEKSVNDD
  885-  903 (35.08/21.38)	LNMFVD............SNQ...DARRRSVNED
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP32876 with Med14 domain of Kingdom Metazoa
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