<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP32874

Description Mediator complex subunit 12
SequencePPPPQDELTALNVKQGFNNQPAISGDEHGSAKNVNFNPAKISSNFSSIIAEKLRCNTLPDTGRRKPQVNQKDNFWLVTARSQSAINNWFTDLAGTKPLTHLAKKVPIFSKKEEVFGYLAKYTVPVMRAAWLIKMTCAYYAAITETKVKKRHVIDPFIEWTQIITKYLSEQLQKIAEFYRQLPGQGCGSPSGPMPQEVEQALKQWDYNEKLAMFMFQDGMLDRHEFLTWVLECFEKIRSGEDEFLKMLLPLLLRYSGEFVQSAYLSRRLAYFCTRRLAMQLDGAGGHPPHILSTQTGNALPSTPTPQPAAGNPPPSPFSDLLLCPQHRPVVYGLSCILQSIILCCPSALVWHYSLTDSRIKTGSPLDHLPIAPSNLPMPGGNSAFTQQVRAKLREIEQQIKERGQAVEVRWSFDKCQETTAGFTIGRVLHTLEVLDSHSFERSDFSNSLDSLYNRIFGLGPTKDSHEISPDDDAVVALLCEWAVSYKRSGRHRAMVVAKLLEKRQAEIEAERCGDSEVVDEKGSISSGSLSAASAPVFQDVLMQFLDTQAPMLTDPGKENEKVEFFNLVLLFCELIRHDVFSHNIYMCTLISRGDLAMDSHGPRPPSPFDDPAEEHDRKETEGNSGIKLEDTGLSEPMDIDHNSSALFDDMEKTDFSMFSPPMHCESKASPSPEKPDPEKETKPLLKDKSAEGMLASLYDQPRHIQYATHFPIPQEESCSHECNQRLVVLFGVGKQRDDARHTIKKITKDILKVLNRKSTAETDLCTEAKRILPMNPILLTLVGGEEGQKRKKSKPEAFPTAEDIFAKFQHLSHFDQHQVTSQVSRNVLEQITSFALGMSYHLPLVQHVQFIFDLMEYSLNISGLIDFAIQLLNELSVVEAELLLKSSDLVGSYTTSLCLCIVAVLRHYHSCLILNQDQMAQVFEGLCGVVKHGMNRSDGSSAERCILAYLYDLYTSCSHLKSKFGELFSDFCSKVKNTIYCNVEPSDSNMLWEPEFMIDTIENPSAHNFTYTNLGKSLNENPANRYSFVCNALMHVCVGHHDPDRVNDIAILCAELTGYCKSLSAEWLGVLKALCCSSNNGTCGFNDLLCNVDVSDLSFHDSLATFVAILIARQCLLLEDLIRCAAIPSLLNAACSEQDSEPGARLTCRILLHLFKTPQLNPCQQDGNKPTVGIRSSCDRHLLAASQNRIVDGAVFAVLKAVFVLGDAELKGSGFSHPGGVDDLMDDEMGTRKAGGRVVTVETASLDIYAKYVLRSICQQEWVGERCLKSLCEDSNDLQDPVLSSTQAQRLMQLICYPHRLLDNEEGENPQRQRIKRILQNLDQWTMRQSSLELQLMIKQTANNEMNSLLENIAKATIEVFQQSAETSSASSAGNGVNNLSSSASATPASNKSKPILSSLERSGVWLVAPLIAKLPTSVQGHVLKAAGEELEKGQHLGSSSRKERDRQKQKSMSLLSQQPFLSLVLTCLKGQDEQREGLLTSLYSQVQQIVTNWREDQYQDDCKAKQLMHEALKLRLNLVGGMFDTVQRSTQQTTEWAVLLLDIISSGTVDMQSNNELFTTVLDMLSVLINGTLAADMSSISQGSMEENKRAYMNLVKKLRKELGDRQSDSLEKVRQLLPLPKQTRDVITCEPQGSLIDTKGNKIAGFDSIFKKEGLQVSTKQKISPWDLFEGLKHSAPLSWGWFGTVRVDRKVSRFEEQQRLLLYHTHLKPKPRSYYLEPLPLPPEEEEPPTPVTLEPEKKAVEPTKADKTSSNPATSTEERKKKQSKTKKRNQSASKSEDFVLGPSRGVSYGVGMPTDLLHHQAGSTMSRLAYGQSPVGLYAQNQPLPAGGPRLDTSYRPVRMPLGKLVQSRPPYSGVLPSGMGSMMGIDPSYKPAVYRQQPPVSQGQILRQQLQAKLQGQGIMGQQPVRQMAPTPSYGTLQPSQGYTSYVSHIGLQQHPSQSGTMVPPTYSGQPYQNSHPSSNPALVDPVRQMQQRPSGYVHQQAPGYGHTLGNTQSRFPHQSIQQAPMMSGMNHLGPQGVPSGIRPSQILPVTQCEVKRKNKQMHKKKHKNLTCSCSLAVGQEMILNLNRLQELCWYVWKHFENRSGKYSVKQPQVSTVPQPQAQGQPPGLGMQALPPQQPIVSVPSETEFQRQGLQQTQQQQQTAALVRQLQQQLSNTQPQQNNNPFGRY
Length2175
PositionKinase
OrganismAnas platyrhynchos platyrhynchos (Northern mallard)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Archelosauria> Archosauria> Dinosauria> Saurischia> Theropoda> Coelurosauria> Aves> Neognathae> Galloanserae> Anseriformes> Anatidae> Anatinae> Anas.
Aromaticity0.07
Grand average of hydropathy-0.430
Instability index53.15
Isoelectric point7.07
Molecular weight242418.46
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:Ensembl

GO - Biological Function
beta-catenin binding	GO:0008013	IEA:InterPro
chromatin binding	GO:0003682	IEA:Ensembl
protein C-terminus binding	GO:0008022	IEA:Ensembl
protein domain specific binding	GO:0019904	IEA:Ensembl
RNA polymerase II cis-regulatory region sequence-specific DNA binding	GO:0000978	IEA:Ensembl
thyroid hormone receptor binding	GO:0046966	IEA:Ensembl
transcription coactivator activity	GO:0003713	IEA:Ensembl

GO - Biological Process
axis elongation involved in somitogenesis	GO:0090245	IEA:Ensembl
canonical Wnt signaling pathway	GO:0060070	IEA:Ensembl
embryonic brain development	GO:1990403	IEA:Ensembl
embryonic neurocranium morphogenesis	GO:0048702	IEA:Ensembl
endoderm development	GO:0007492	IEA:Ensembl
heart development	GO:0007507	IEA:Ensembl
neural tube closure	GO:0001843	IEA:Ensembl
oligodendrocyte development	GO:0014003	IEA:Ensembl
positive regulation of transcription initiation from RNA polymerase II promoter	GO:0060261	IEA:Ensembl
post-anal tail morphogenesis	GO:0036342	IEA:Ensembl
Schwann cell development	GO:0014044	IEA:Ensembl
spinal cord development	GO:0021510	IEA:Ensembl
stem cell population maintenance	GO:0019827	IEA:Ensembl
Wnt signaling pathway, planar cell polarity pathway	GO:0060071	IEA:Ensembl









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP32874
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     141.96|      33|      34|    1810|    1842|       1
---------------------------------------------------------------------------
 1810- 1837 (44.15/22.02)	.........MSRLAYGQSPVG.LYAQNQPLPAG.GPRL..D
 1838- 1872 (36.20/16.55)	TSYRPvrmpLGKLVQSRPP....Y..SGVLPSGmGSMMgiD
 1873- 1889 (22.52/ 7.15)	PSYKP................aVYRQQPPVSQG........
 1930- 1950 (39.09/18.54)	TSYV.............SHIG.L..QQHP.SQS.GTMV..P
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     222.73|      72|     108|    1608|    1683|       2
---------------------------------------------------------------------------
 1608- 1683 (120.94/84.43)	QSDSLEKvrqlLPLPKQTRD...VITCEPQGSLID.TKGNKIAG..FDSIFKKEGLQVSTKQKISPWDLFEG..LKHSAPLSWG
 1715- 1794 (101.80/62.51)	RSYYLEP....LPLPPEEEEpptPVTLEPEKKAVEpTKADKTSSnpATSTEERKKKQSKTKKRNQSASKSEDfvLGPSRGVSYG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     234.25|      72|     108|     914|     987|       3
---------------------------------------------------------------------------
  914-  987 (119.19/86.66)	LNQDQmAQVFEGLCGVVKH.GMNRSDGSSAERcILAYLYDLYTSCSHLKSK.FGELFSDFCSKVK.....NTIYCNVEPSD
 1018- 1096 (115.06/73.63)	LNENP.ANRYSFVCNALMHvCVGHHDPDRVND.IAILCAELTGYCKSLSAEwLGVLKALCCSSNNgtcgfNDLLCNVDVSD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.63|      11|     112|     185|     195|       4
---------------------------------------------------------------------------
  185-  195 (25.18/13.41)	GCGSPSGPMPQ
  296-  306 (22.45/11.04)	GNALPSTPTPQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     184.71|      59|     112|     501|     563|       5
---------------------------------------------------------------------------
  501-  563 (91.44/70.81)	EKRQAEIEaercGDSEV.VDEKGSISSGSLSAASAPVFQDV.LMQFLDTQAPMLTD....PGKENEKVE
  614-  678 (93.28/61.77)	EHDRKETE....GNSGIkLEDTGLSEPMDIDHNSSALFDDMeKTDFSMFSPPMHCEskasPSPEKPDPE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      99.51|      20|      61|    1909|    1929|       6
---------------------------------------------------------------------------
 1909- 1928 (39.83/18.27)	QP...VRQMAP......TPSYGTLQPSQG
 1971- 1990 (36.31/15.59)	DP...VRQMQQ......RPSGYVHQQAPG
 2112- 2139 (23.36/10.17)	PPglgMQALPPqqpivsVPSETEFQ.RQG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     211.68|      72|     614|    1380|    1500|      10
---------------------------------------------------------------------------
 1380- 1462 (101.04/65.30)	LSSSASATP.ASNKSKPILSSLERSGvwlvaPliAKLPTSVQ.GHVLKAAGEELE.KGQHLgsssRKERDRQKQKSMSL.LSQQPFL
 1995- 2070 (110.64/38.81)	LGNTQSRFPhQSIQQAPMMSGMNHLG.....P..QGVPSGIRpSQILPVTQCEVKrKNKQM....HKKKHKNLTCSCSLaVGQEMIL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      86.10|      26|     609|    1531|    1556|      13
---------------------------------------------------------------------------
 1531- 1556 (45.34/28.74)	TQQTTEWAVLL..LDIISSGTVDMQSNN
 2143- 2170 (40.76/25.04)	TQQQQQTAALVrqLQQQLSNTQPQQNNN
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP32874 with Med12 domain of Kingdom Metazoa
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