<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP32863

Description Mediator of RNA polymerase II transcription subunit 13
SequenceVEEGLWENGLSYECRTLLFKAIHNLLERCLMDKNFVRIGKWFIRPYDKDEKPVNKSEHLSCAFTFFLHGESNVCTSVEIAQHQPIYLINEEHIHMAQSSPSPFQVLVSPYGLNGTLTGQSYKMSDPATRKLMEEWQYFYPMVLKKKEGMKEEEELGYDNDFPVAVEVIVGGVRMVYPSAFVLISQSDIPVSQNAANTGGHINVGQQGLGSMKDPASTCGMPLTPPTSPEQAVMGESGCSQSSISHSAVQEGTVSVHSPKKSSKITPKFHNHMVHRVWKECILNRSQSKRSQITTANLEEEVPNNTVSWDFVDPVQRVSCSCSRHKVFKQRCAAGSSRPPTINQPGFSVGTSSSSSLPPPASSKHKTTERQEKGDKLQKRPMMPFHHRPSVTEELCMEQDTSGQKLGLAGMDPSLEVPNSRKYEKPLSIPARNPSKQINMNPMDSPHSPTSPLPPTLSPQPRGQEAENLDPPSVPVNQPAHWGWGLELQPLPSLEDRTVLVGPRLPLMAEVSETALYCGLIQNNESLDMWRTYSVPPSDDPEFRPPDLPCERYDSKMEVNSDSTALKRLLAQPNKRFKILEEQKPVQTLNYLDPLPLIQQPGEGLGDASDPYTFEDGDIKYSFTGNKKCKLGAEKDPLKKNKSEDGSGTKEIPTTGHSTPVPDGKDAMSIFSSAPKTDTRQDNAASRVGSSSLTQVTDLAPSLHDLDNIFDNSDEDELGAVSPALRSSKMPAVGSEERPVGKDGRTAVPYPPTVADLQRMFPTPPSLEQHPAFSPVMSYKDGISSETVTTLGMMESPMVNMVPTQLAEFKMEVEDGLGSPKPEEIKDFSYVHKVPSFQPFVGSSMFAPLKILPSQCLLPLKIPDACIFRPSWAVPPKIEQLPLPPAAPFIRDGYNNVPSVGSLADQDYLQMNTPQMNTPVTLNSTAPASNSGAGVLPSPATPRFSVPTPRTPRTPRTPRGGGTASGQGSVKYDSTDQGSPASTPSTTRPLNSVEPATVQPIPEAHSLYVTLILSDSVLNIFKDRNFDSCCICACNMNIKGADVGLYIPDSSNEDQYRCTCGFSAIMNRKLGYNSGLFIEDELDIFGKTSDIGQAAERRLMICQSNLISQMGEGARRTQEPPMSLLLLLQNQHTQPFTSLSCLDYMSSNNRQTLPCMNWSYDRLQADSNDSWIECFNALEQGRQYVDNPTGGKVDEALVRSATVHSWPHSNVLDISMLSSQDVVRMLLSLQPFLQDAIQKKRTGRTWENIQHVQGPLTWQQFHKMAGRGTYGSEESPEPLPIPTLLVGYDKDFLTISPFSLPFWERLLLDPYGGHRDVAYIVVCPENEALLDGAKTFFRDLSAVYEMCRLGQHKPICKVLRDGIMRVGKTVAQKLTDELVSEWFNQPWGTEECDNHSRLKLYAQVCRHHLAPYLATLQLDSSLLLPPKYQTPASQAQTIPGNTGPAPSNSTCLSASGAAPTGSSFNSTPNGGTTSLPAGSSSSSGSSVPQLSASSATPSVNQMTTTSTPGFSGNIGSGQNASAGGNTADRSQGSTGPGGDTESGQNIPQQQQEGQEGVTERERIGIPTEPESADSNAYPPAVVIYMVDPFTYTADEESASTNFWLLSLMRCYTEMLDNLPENMRNSFILQIVPCQYMLQTMKDEQVFYIQHLKSLAFSVYCQCRRPLPTQIHIKSLTGFGPAASIEMTLKNPERPSPIQLYSPPFILAPIKDKQTELGETFGEASQKYNVLFVGYCLSHDQRWLLASCTDLHGELLETCIVNIDLPNRSRRSKLSARKIGLQKLWEWCIGIVQMTSLPWRVVIGRLGRLGHGELKDWSILLGECSLQTISKQLKEVCRMCGISSADSPSILSACLVAMEPQGSFVVMPDAVTMGSVFGRSTALNLQSSQLNTPQDASCTHILVFPTSATIQVAPANYPNEDGFSPTNDDMFDLPFPDDMDNDIRILITGNLHSSPNSSPVPSPGSPSGIGVGSHFQHSRSQGERLLSREAPEELKQQPLALGYFVSTAKAENLPQWFWSSCPQAQNQCPLFLKASLHHHISVAQTDELLPARNSQRVPHPLDSKTTSDVLRFVLEQYNALSWLTCNPATQDRSSCLPVHFVVLTQLYNAIMNIL
Length2112
PositionMiddle
OrganismAnas platyrhynchos platyrhynchos (Northern mallard)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Archelosauria> Archosauria> Dinosauria> Saurischia> Theropoda> Coelurosauria> Aves> Neognathae> Galloanserae> Anseriformes> Anatidae> Anatinae> Anas.
Aromaticity0.07
Grand average of hydropathy-0.416
Instability index60.87
Isoelectric point5.60
Molecular weight232034.77
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364134

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP32863
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     114.22|      22|     109|     760|     781|       1
---------------------------------------------------------------------------
  760-  781 (44.59/23.95)	FPTPPSLEQHPAFSPVMSY.KDG
  871-  892 (36.09/17.60)	WAVPPKIEQLP.LPPAAPFiRDG
 1902- 1920 (33.54/15.70)	FPTSATIQVAPANYP...N.EDG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      64.53|      18|     137|     451|     470|       2
---------------------------------------------------------------------------
  451-  470 (29.77/14.97)	PLPptLSPQPRGQEAENLDP
  593-  610 (34.76/12.59)	PLP..LIQQPGEGLGDASDP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     194.61|      57|     912|     636|     711|       3
---------------------------------------------------------------------------
  651-  711 (92.30/74.77)	IPTTGHSTPVPDGKDAMSIFSSAPKTDTRQDNAAsrvgSSSLTQVTDLAPSLHDLDNIFDN
 1564- 1620 (102.31/49.83)	IPTEPESADSNAYPPAVVIYMVDPFTYTADEESA....STNFWLLSLMRCYTEMLDNLPEN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     206.11|      62|     914|      76|     192|       4
---------------------------------------------------------------------------
   98-  161 (108.84/146.90)	SSPSPFQVLVS..PY...GLNGTLTGQSYKMSDPATRKLmeEWQYFYPMVLKKKEGMKEEEE........LGYDNDF
 1217- 1291 (97.27/40.15)	SSQDVVRMLLSlqPFlqdAIQKKRTGRTWENIQHVQGPL..TWQQFHKMAGRGTYGSEESPEplpiptllVGYDKDF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     265.45|      63|     576|     893|     966|       5
---------------------------------------------------------------------------
  895-  966 (106.03/60.21)	NVPSVGSladqdylqmNTPQMN....TPVTLNSTAPASNSG.AGVLPSPAT.PRFSVPTPRTPRTPRTPRGGGTA..SGQ
 1425- 1477 (65.53/22.94)	..................PKYQ....TPASQAQTIP.GNTG.PA..PSNSTcLSASGAAPTGSSFNSTPNGGTTSlpAG.
 1478- 1543 (93.90/37.01)	SSSSSGS.........SVPQLSassaTP.SVNQMTTTSTPGfSGNIGSGQN.ASAGGNTADRSQGSTGP.GGDTE..SGQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     164.32|      51|    1505|     253|     341|       6
---------------------------------------------------------------------------
  274-  330 (83.55/85.63)	HRVWKECI.LNRSQSKRSQITTANLEEEVPNNTVSWDFvdpvqrVSCSCSRHKVFKQ.....R
 1780- 1836 (80.77/31.58)	QKLWEWCIgIVQMTSLPWRVVIGRLGRLGHGELKDWSI......LLGECSLQTISKQlkevcR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     117.39|      35|    1505|     517|     573|       7
---------------------------------------------------------------------------
  406-  440 (62.85/22.40)	GLAGMDPSLE......VPNSRKYE.KPLSIPARNPSKQINMN
  518-  559 (54.54/49.72)	GLIQNNESLDmwrtysVPPSDDPEfRPPDLPCERYDSKMEVN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      38.79|      10|     914|      76|      85|       9
---------------------------------------------------------------------------
   76-   85 (19.56/11.25)	SVEIAQHQPI
  991- 1000 (19.23/10.93)	SVEPATVQPI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     116.33|      35|     677|    1164|    1199|      13
---------------------------------------------------------------------------
 1164- 1199 (59.07/48.79)	ADSNDSWIECFNALE.QGrQYVDNPTGGKVDEALVRS
 1843- 1878 (57.26/41.62)	ADSPSILSACLVAMEpQG.SFVVMPDAVTMGSVFGRS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     152.53|      48|     413|    1622|    1675|      20
---------------------------------------------------------------------------
 1622- 1675 (76.02/75.03)	RNSfilQIVPCQYMLQTMKDEQVFYIQHLKSLAFsVYC....QCRRP.LPtqIHIKSLT
 2050- 2102 (76.51/54.57)	RNS...QRVPHPLDSKTTSDVLRFVLEQYNALSW.LTCnpatQDRSScLP..VHFVVLT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      61.02|      16|      21|    1300|    1315|      21
---------------------------------------------------------------------------
 1300- 1315 (32.63/23.10)	PFWERLLLDPYGGHRD
 1323- 1338 (28.39/18.94)	PENEALLDGAKTFFRD
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP32863 with Med13 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) GAEKDPLKKNKSEDGSGTKEIPTTGHSTPVPDGKDAMSIFSSAPKTDTRQDNAASRVGSSSLTQVTDLAPSLHDLDNIFDNSDEDELGAVSPALRSSKMPAVGSEERPVGKDGRTAVPYPPTVADLQRMFPTPPSLE
2) GSLADQDYLQMNTPQMNTPVTLNSTAPASNSGAGVLPSPATPRFSVPTPRTPRTPRTPRGGGTASGQGSVKYDSTDQGSPASTPSTTRPLNSVEPATVQ
3) KDPASTCGMPLTPPTSPEQAVMGESGCSQS
4) NLHSSPNSSPVPSPGSPSGIGVGSHFQHSRSQGERLLSREAPE
5) PPKYQTPASQAQTIPGNTGPAPSNSTCLSASGAAPTGSSFNSTPNGGTTSLPAGSSSSSGSSVPQLSASSATPSVNQMTTTSTPGFSGNIGSGQNASAGGNTADRSQGSTGPGGDTESGQNIPQQQQEGQEGVTERERIGIPTEPESA
6) RCAAGSSRPPTINQPGFSVGTSSSSSLPPPASSKHKTTERQEKGDKLQKRPMMPFHHRPSVTEELCMEQDTSGQKLGLAGMDPSLEVPNSRKYEKPLSIPARNPSKQINMNPMDSPHSPTSPLPPTLSPQPRGQEAENLDPPSVPVNPALYGSGLELQ
709
978
291
2026
1502
409
845
1076
320
2068
1649
566










Molecular Recognition Features






MoRF SequenceStartStop




NANANA