<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP32841

Description Isoform 2 of Transcription elongation factor A protein 2
SequenceMMGKEEEIARIARRLDKMVTKKSAEGAMDLLRELKAMPITLHLLQSTRVGMSVNALRKQSSDEEVIALAKSLIKSWKKLLDASDAKARERGRGMPLPTSSRDASEAPDPSRKRPELPRAPSTPRITTFPPVPVTCDAVRNKCREMLTAALQTDHDHVAIGADCERLSAQIEECIFRDVGNTDMKYKNRVRSRISNLKDAKNPDLRRNVLCGAITPQQIAVMTSEEMASDELKEIRKAMTKEAIREHQMARTGGTQTDLFTCGKCRKKNCTYTQVQTRSSDEPMTTFVVCNECGNRWKFC
Length272
PositionUnknown
OrganismHomo sapiens (Human)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Primates> Haplorrhini> Catarrhini> Hominidae> Homo.
Aromaticity0.03
Grand average of hydropathy-0.622
Instability index55.38
Isoelectric point9.32
Molecular weight33600.46
Publications
PubMed=8566795
PubMed=14702039
PubMed=11780052
PubMed=15489334
PubMed=9441762
PubMed=12034815
PubMed=12943681
PubMed=18655026
PubMed=22814378

Function

Annotated function Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'-terminus. 
GO - Cellular Component
centrosome	GO:0005813	IDA:HPA
nucleoplasm	GO:0005654	IDA:HPA
transcription elongation factor complex	GO:0008023	NAS:UniProtKB

GO - Biological Function
DNA binding	GO:0003677	IEA:UniProtKB-KW
zinc ion binding	GO:0008270	IEA:InterPro

GO - Biological Process
DNA-templated transcription, elongation	GO:0006354	NAS:UniProtKB
positive regulation of transcription by RNA polymerase II	GO:0045944	IEA:Ensembl
regulation of DNA-templated transcription, elongation	GO:0032784	NAS:UniProtKB









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP32841
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     151.82|      45|     123|      98|     142|       1
---------------------------------------------------------------------------
   98-  142 (81.95/49.46)	TSSRDASEAPDPSRK..RPELPRAPSTPRITTFPPVPVTCDAVRNK.C
  222-  269 (69.87/41.12)	TSEEMASDELKEIRKamTKEAIREHQMARTGGTQTDLFTCGKCRKKnC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     101.36|      34|      54|       5|      39|       2
---------------------------------------------------------------------------
    5-   39 (50.17/38.68)	EEEIARIARRLDKmVTKKSAEGAMDLLREL.KAMPI
   62-   96 (51.19/34.17)	DEEVIALAKSLIK.SWKKLLDASDAKARERgRGMPL
---------------------------------------------------------------------------











Associated diseases
Disease


























Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP32841 with Med26 domain of Kingdom Metazoa
Unable to open file!