<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP32841

Description Isoform 2 of Transcription elongation factor A protein 2
SequenceMMGKEEEIARIARRLDKMVTKKSAEGAMDLLRELKAMPITLHLLQSTRVGMSVNALRKQSSDEEVIALAKSLIKSWKKLLDASDAKARERGRGMPLPTSSRDASEAPDPSRKRPELPRAPSTPRITTFPPVPVTCDAVRNKCREMLTAALQTDHDHVAIGADCERLSAQIEECIFRDVGNTDMKYKNRVRSRISNLKDAKNPDLRRNVLCGAITPQQIAVMTSEEMASDELKEIRKAMTKEAIREHQMARTGGTQTDLFTCGKCRKKNCTYTQVQTRSSDEPMTTFVVCNECGNRWKFC
Length272
PositionUnknown
OrganismHomo sapiens (Human)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Primates> Haplorrhini> Catarrhini> Hominidae> Homo.
Aromaticity0.03
Grand average of hydropathy-0.622
Instability index55.38
Isoelectric point9.32
Molecular weight33600.46
Publications
PubMed=8566795
PubMed=14702039
PubMed=11780052
PubMed=15489334
PubMed=9441762
PubMed=12034815
PubMed=12943681
PubMed=18655026
PubMed=22814378

Function

Annotated function Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'-terminus. 
ECO:0000269	PubMed:12034815
GO - Cellular Component
centrosome	GO:0005813	IDA:HPA
nucleoplasm	GO:0005654	IDA:HPA
transcription elongation factor complex	GO:0008023	NAS:UniProtKB
GO - Biological Function
DNA binding	GO:0003677	IEA:UniProtKB-KW
zinc ion binding	GO:0008270	IEA:InterPro
GO - Biological Process
DNA-templated transcription, elongation	GO:0006354	NAS:UniProtKB
positive regulation of transcription by RNA polymerase II	GO:0045944	IEA:Ensembl
regulation of DNA-templated transcription, elongation	GO:0032784	NAS:UniProtKB

Interaction

Binary Interactions
[Q15560<-->Q6UY14-3: ADAMTSL4]	NbExp=3	EBI-710310,EBI-10173507
[Q15560<-->O95994: AGR2]	NbExp=3	EBI-710310,EBI-712648
[Q15560<-->Q6RW13-2: AGTRAP]	NbExp=3	EBI-710310,EBI-11522760
[Q15560<-->P13196: ALAS1]	NbExp=3	EBI-710310,EBI-3905054
[Q15560<-->Q9Y2J4: AMOTL2]	NbExp=3	EBI-710310,EBI-746752
[Q15560<-->Q8N2F6-2: ARMC10]	NbExp=3	EBI-710310,EBI-12902762
[Q15560<-->Q9Y2T1: AXIN2]	NbExp=3	EBI-710310,EBI-4400025
[Q15560<-->Q9BYV9: BACH2]	NbExp=3	EBI-710310,EBI-1642333
[Q15560<-->Q6PI77: BHLHB9]	NbExp=3	EBI-710310,EBI-11519926
[Q15560<-->Q8TD16-2: BICD2]	NbExp=3	EBI-710310,EBI-11975051
[Q15560<-->Q8N9W6-4: BOLL]	NbExp=3	EBI-710310,EBI-11983447
[Q15560<-->Q96KE9-2: BTBD6]	NbExp=3	EBI-710310,EBI-12012762
[Q15560<-->Q8NA61-2: CBY2]	NbExp=3	EBI-710310,EBI-11524851
[Q15560<-->Q96JN2-2: CCDC136]	NbExp=3	EBI-710310,EBI-10171416
[Q15560<-->Q569K6: CCDC157]	NbExp=3	EBI-710310,EBI-13289565
[Q15560<-->Q9C0F1: CEP44]	NbExp=3	EBI-710310,EBI-744115
[Q15560<-->Q8TAP6: CEP76]	NbExp=3	EBI-710310,EBI-742887
[Q15560<-->Q8IZR5-2: CMTM4]	NbExp=3	EBI-710310,EBI-17278014
[Q15560<-->Q9NX76: CMTM6]	NbExp=3	EBI-710310,EBI-1054315
[Q15560<-->Q8N137: CNTROB]	NbExp=3	EBI-710310,EBI-947360
[Q15560<-->Q5RI15: COX20]	NbExp=3	EBI-710310,EBI-2834035
[Q15560<-->A8MQ03: CYSRT1]	NbExp=3	EBI-710310,EBI-3867333
[Q15560<-->O75553: DAB1]	NbExp=3	EBI-710310,EBI-7875264
[Q15560<-->P17661: DES]	NbExp=3	EBI-710310,EBI-1055572
[Q15560<-->Q92997: DVL3]	NbExp=3	EBI-710310,EBI-739789
[Q15560<-->Q96JC9: EAF1]	NbExp=3	EBI-710310,EBI-769261
[Q15560<-->Q96CJ1: EAF2]	NbExp=3	EBI-710310,EBI-1245604
[Q15560<-->Q96B26: EXOSC8]	NbExp=3	EBI-710310,EBI-371922
[Q15560<-->Q13158: FADD]	NbExp=3	EBI-710310,EBI-494804
[Q15560<-->Q8IZU0: FAM9B]	NbExp=3	EBI-710310,EBI-10175124
[Q15560<-->A0A0C3SFZ9: FCHO1]	NbExp=3	EBI-710310,EBI-11977403
[Q15560<-->P51114-2: FXR1]	NbExp=3	EBI-710310,EBI-11022345
[Q15560<-->O95995: GAS8]	NbExp=3	EBI-710310,EBI-1052570
[Q15560<-->O75420: GIGYF1]	NbExp=3	EBI-710310,EBI-947774
[Q15560<-->Q08379: GOLGA2]	NbExp=6	EBI-710310,EBI-618309
[Q15560<-->Q92917: GPKOW]	NbExp=7	EBI-710310,EBI-746309
[Q15560<-->Q4V328: GRIPAP1]	NbExp=3	EBI-710310,EBI-717919
[Q15560<-->Q9BYE0: HES7]	NbExp=3	EBI-710310,EBI-12163087
[Q15560<-->A8MV81: HIGD1C]	NbExp=3	EBI-710310,EBI-12809676
[Q15560<-->O00291: HIP1]	NbExp=3	EBI-710310,EBI-473886
[Q15560<-->Q6NT76: HMBOX1]	NbExp=3	EBI-710310,EBI-2549423
[Q15560<-->O75031: HSF2BP]	NbExp=3	EBI-710310,EBI-7116203
[Q15560<-->Q13422-7: IKZF1]	NbExp=3	EBI-710310,EBI-11522367
[Q15560<-->Q9H2S9: IKZF4]	NbExp=3	EBI-710310,EBI-1640423
[Q15560<-->Q9H3M0: KCNF1]	NbExp=3	EBI-710310,EBI-6918743
[Q15560<-->Q9H3F6: KCTD10]	NbExp=3	EBI-710310,EBI-2505886
[Q15560<-->Q96MP8-2: KCTD7]	NbExp=3	EBI-710310,EBI-11954971
[Q15560<-->Q8N8K9: KIAA1958]	NbExp=6	EBI-710310,EBI-10181113
[Q15560<-->Q6A162: KRT40]	NbExp=3	EBI-710310,EBI-10171697
[Q15560<-->P60409: KRTAP10-7]	NbExp=3	EBI-710310,EBI-10172290
[Q15560<-->P60410: KRTAP10-8]	NbExp=3	EBI-710310,EBI-10171774
[Q15560<-->P59991: KRTAP12-2]	NbExp=3	EBI-710310,EBI-10176379
[Q15560<-->P60328: KRTAP12-3]	NbExp=3	EBI-710310,EBI-11953334
[Q15560<-->P26371: KRTAP5-9]	NbExp=3	EBI-710310,EBI-3958099
[Q15560<-->Q9BQD3: KXD1]	NbExp=3	EBI-710310,EBI-739657
[Q15560<-->P48059-3: LIMS1]	NbExp=3	EBI-710310,EBI-12864460
[Q15560<-->Q9Y250: LZTS1]	NbExp=3	EBI-710310,EBI-1216080
[Q15560<-->Q9BRK4: LZTS2]	NbExp=3	EBI-710310,EBI-741037
[Q15560<-->P43364: MAGEA11]	NbExp=5	EBI-710310,EBI-739552
[Q15560<-->P27448: MARK3]	NbExp=2	EBI-710310,EBI-707595
[Q15560<-->P23508: MCC]	NbExp=3	EBI-710310,EBI-307531
[Q15560<-->P21741: MDK]	NbExp=3	EBI-710310,EBI-722444
[Q15560<-->P50222: MEOX2]	NbExp=3	EBI-710310,EBI-748397
[Q15560<-->Q6FHY5: MEOX2]	NbExp=3	EBI-710310,EBI-16439278
[Q15560<-->Q9UJV3-2: MID2]	NbExp=3	EBI-710310,EBI-10172526
[Q15560<-->Q13064: MKRN3]	NbExp=3	EBI-710310,EBI-2340269
[Q15560<-->Q8NCY6: MSANTD4]	NbExp=3	EBI-710310,EBI-7850168
[Q15560<-->Q5JR59-3: MTUS2]	NbExp=3	EBI-710310,EBI-11522433
[Q15560<-->Q15742: NAB2]	NbExp=3	EBI-710310,EBI-8641936
[Q15560<-->Q8N987: NECAB1]	NbExp=3	EBI-710310,EBI-11956853
[Q15560<-->Q7Z6G3-2: NECAB2]	NbExp=3	EBI-710310,EBI-10172876
[Q15560<-->Q9H4L5: OSBPL3]	NbExp=3	EBI-710310,EBI-1051317
[Q15560<-->Q4G0R1: PIBF1]	NbExp=3	EBI-710310,EBI-14066006
[Q15560<-->Q9NRD5: PICK1]	NbExp=3	EBI-710310,EBI-79165
[Q15560<-->Q8WWB5: PIH1D2]	NbExp=3	EBI-710310,EBI-10232538
[Q15560<-->Q8ND90: PNMA1]	NbExp=3	EBI-710310,EBI-302345
[Q15560<-->Q96PV4: PNMA5]	NbExp=3	EBI-710310,EBI-10171633
[Q15560<-->P78424: POU6F2]	NbExp=3	EBI-710310,EBI-12029004
[Q15560<-->P41219: PRPH]	NbExp=3	EBI-710310,EBI-752074
[Q15560<-->Q93062-3: RBPMS]	NbExp=3	EBI-710310,EBI-740343
[Q15560<-->Q86VR2: RETREG3]	NbExp=3	EBI-710310,EBI-10192441
[Q15560<-->Q96KG9-4: SCYL1]	NbExp=3	EBI-710310,EBI-12023020
[Q15560<-->A1L4H1: SSC5D]	NbExp=3	EBI-710310,EBI-10172867
[Q15560<-->Q96MF2: STAC3]	NbExp=3	EBI-710310,EBI-745680
[Q15560<-->O75558: STX11]	NbExp=3	EBI-710310,EBI-714135
[Q15560<-->Q8N205-2: SYNE4]	NbExp=3	EBI-710310,EBI-12099160
[Q15560<-->Q15633: TARBP2]	NbExp=3	EBI-710310,EBI-978581
[Q15560<-->Q86VP1: TAX1BP1]	NbExp=3	EBI-710310,EBI-529518
[Q15560<-->Q86TI0: TBC1D1]	NbExp=3	EBI-710310,EBI-1644036
[Q15560<-->P15884: TCF4]	NbExp=3	EBI-710310,EBI-533224
[Q15560<-->Q96N21: TEPSIN]	NbExp=3	EBI-710310,EBI-11139477
[Q15560<-->Q12800: TFCP2]	NbExp=3	EBI-710310,EBI-717422
[Q15560<-->Q9NVV9: THAP1]	NbExp=6	EBI-710310,EBI-741515
[Q15560<-->Q6P5X7-2: TMEM71]	NbExp=3	EBI-710310,EBI-12886878
[Q15560<-->Q15025: TNIP1]	NbExp=8	EBI-710310,EBI-357849
[Q15560<-->Q96NM4-3: TOX2]	NbExp=3	EBI-710310,EBI-12815137
[Q15560<-->Q13077: TRAF1]	NbExp=3	EBI-710310,EBI-359224
[Q15560<-->Q12933: TRAF2]	NbExp=7	EBI-710310,EBI-355744
[Q15560<-->P36406: TRIM23]	NbExp=3	EBI-710310,EBI-740098
[Q15560<-->P14373: TRIM27]	NbExp=6	EBI-710310,EBI-719493
[Q15560<-->O00635: TRIM38]	NbExp=3	EBI-710310,EBI-2130415
[Q15560<-->Q8WV44: TRIM41]	NbExp=3	EBI-710310,EBI-725997
[Q15560<-->Q9BYV2: TRIM54]	NbExp=6	EBI-710310,EBI-2130429
[Q15560<-->Q9BZW7: TSGA10]	NbExp=3	EBI-710310,EBI-744794
[Q15560<-->Q70EL1-9: USP54]	NbExp=3	EBI-710310,EBI-11975223
[Q15560<-->P08670: VIM]	NbExp=3	EBI-710310,EBI-353844
[Q15560<-->O15209: ZBTB22]	NbExp=3	EBI-710310,EBI-723574
[Q15560<-->O43298: ZBTB43]	NbExp=3	EBI-710310,EBI-740718
[Q15560<-->Q96BR9: ZBTB8A]	NbExp=3	EBI-710310,EBI-742740
[Q15560<-->Q96C00: ZBTB9]	NbExp=3	EBI-710310,EBI-395708
[Q15560<-->Q15776: ZKSCAN8]	NbExp=3	EBI-710310,EBI-2602314
[Q15560<-->Q8TF50: ZNF526]	NbExp=3	EBI-710310,EBI-11035148
[Q15560<-->Q9UGI0: ZRANB1]	NbExp=3	EBI-710310,EBI-527853

Repeat regions

Repeats

>MDP32841
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     151.82|      45|     123|      98|     142|       1
---------------------------------------------------------------------------
   98-  142 (81.95/49.46)	TSSRDASEAPDPSRK..RPELPRAPSTPRITTFPPVPVTCDAVRNK.C
  222-  269 (69.87/41.12)	TSEEMASDELKEIRKamTKEAIREHQMARTGGTQTDLFTCGKCRKKnC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     101.36|      34|      54|       5|      39|       2
---------------------------------------------------------------------------
    5-   39 (50.17/38.68)	EEEIARIARRLDKmVTKKSAEGAMDLLREL.KAMPI
   62-   96 (51.19/34.17)	DEEVIALAKSLIK.SWKKLLDASDAKARERgRGMPL
---------------------------------------------------------------------------

Associated diseases

Disease


























Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP32841 with Med26 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) KARERGRGMPLPTSSRDASEAPDPSRKRPELPRAPSTPRITTFPP
86
130










Molecular Recognition Features






MoRF SequenceStartStop




NANANA